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Shul'ts EE Bakhvalov SA Martem'ianov VV Petrova TN Syromiatnikova IN Shakirov MM Tolstikov GA 《Prikladnaia biokhimiia i mikrobiologiia》2005,41(1):107-112
Qualitative and quantitative compositions of extracts of birch (Betula pendula Roth.) leaves after natural and artificial defoliations were studied. Composition of the fraction of total lipids was determined. Overall, 11 fatty acids were identified. Differences between the fatty acid compositions of total lipids in the trees subjected to defoliation, consisting in the increase in quantities of short-chain saturated fatty acids and trienoic acids, were detected. Nine individual compounds--six flavones, two flavanones, and one flavanonol--were isolated from the flavonoid fraction by column chromatography. It was found that the total content of extractive substances in birch leaves as well as amounts of free sterols, triterpene compounds, and flavones decreased 1 year after an artificial defoliation and 1 month after depredation of 75% of birch stands by gypsy moth. On the contrary, the contents of flavanones and flavanonol increased. The assay method proposed may be used for studying the compositions of plant extracts. 相似文献
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Il'icheva TN Proniaeva TR Shul'ts EE Tolstikov GA Pokrovskiĭ AG 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2001,(2):53-56
The immunostimulating activity of triterpenes of vegetable origin and their derivatives was studied. The study revealed that glycyrrhizic and betulonic acids, as well as derivatives of ursolic and glycyrrhetinic acids, enhanced the level of specific antibodies to bovine serum albumin in mice. 相似文献
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Shintiapina AB Shul'ts EE Petrenko NI Uzenkova NV Tolstikov GA Pronkina NV Kozhevnikov VS Pokrovskiĭ AG 《Bioorganicheskaia khimiia》2007,33(6):624-628
Derivatives of the available plant triterpenes glycyrrhetic acid and betulin (betulin succinates and amides of betulonic and 18beta-glycyrrhetic acids containing fragments of long-chain amino acids and a peptide) were synthesized. The inhibitory action of these compounds on the growth of MT-4, MOLT-4, CEM. and Hep G2 tumor cells and their effect on the apoptosis of these cells were studied. It was shown that betulonic acid amides are more effective inhibitors of the tumor cell growth than the corresponding amides of glycyrrhetic acid. It was also found that betulonic acid amides containing fragments of caprylic, pelargonic, and undecanoic acids are more effective inhibitors of tumor cell growth than betulinic acid. The 17-dipeptide derivative of betulonic acid N-{N-[3-oxo-20(29)-lupen-28-oyl]-9-aminononanoyl}-3-amino-3-phenylpropionic acid exhibited the maximum inhibitory activity toward the tumor cells studied. Data on the induction of apoptosis in tumor cells by betulin derivatives at a concentration of 10 microg/ml were obtained by flow cytometry. The amides of betulonic acid proved to be the most effective inducers of apoptosis. 相似文献
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Gavrish AS Khadzhinskiĭ VG Sergienko OV Verbitskiĭ VV Shul'ts NV Trunina IV 《T?Sitologii?a i genetika》2001,35(5):54-59
Morphogenesis of adaptational, disadaptational, and alterative changes affected structure and function of all live-supporting systems (contractile elements, macroergic phosphate synthesis, intracellular regeneration, and electrolyte exchange control) was studied in cardiomyocytes under experimental chronic stress using ultrastructural and cytochemical methods. 相似文献
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Kharitonov IuV Shul'ts ÉÉ Shakirov MM Pokrovskiĭ MA Pokrovskiĭ AG Tolstikov GA 《Bioorganicheskaia khimiia》2012,38(1):127-136
Condensation of methyl 16-aminomethyllambertianate with N-Boc-omega-amino acids leads smoothly to 16-(N-Boc-aminononan)- and 16-(N-Boc-aminoundecan)amidomethyllabdanoids. The amide of bicyclo[2.2.1]heptan-1,2-dicarbocylic acid with a labdanoid substituent was obtained under the reaction of methyl aminomethyllambertianate with bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic anhydride. Intereaction of methyl 16-aminomethyllambertianate with chloroacetyl chloride leads to methyl 16-(chloroacetylaminomethyl)lambertianate; condensation of this compound with amino acid methyl ethers the corresponding amides of methyl lambertianate was obtained. The resulting compounds are more (compared with lambertianic acid) cytotoxicity in the cell lines CEM-13, MT-4 and U-937 with an CCID50 concentration of 3.9-9.9 microM. 相似文献
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