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Maryam Ghodrati Siahmazgi Mohammad Ali Nasiri Khalili Mehdi Zeinoddini Fathollah Ahmadpour Sirus Khodadadi 《International journal of peptide research and therapeutics》2020,26(2):767-774
Immunotoxin is a recombinant fusion toxin which has been developed to kill cancer cells selectively. DT389GCSF as a new immunotoxin consists of a truncated 相似文献
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Mohammad Foad Abazari Fatemeh Soleimanifar Seyed Ehsan Enderami Navid Nasiri Fatemeh Nejati Seyed Ahmad Mousavi Masoud Soleimani Jafar Kiani Pegah Ghoraeian Mousa Kehtari 《Journal of cellular biochemistry》2020,121(2):1169-1181
Human-induced pluripotent stem cells-derived hepatocyte-like cells (hiPSCs-HLCs) holds considerable promise for future clinical personalized therapy of liver disease. However, the low engraftment of these cells in the damaged liver microenvironment is still an obstacle for potential application. In this study, we explored the effectiveness of decellularized amniotic membrane (dAM) matrices for culturing of iPSCs and promoting their differentiation into HLCs. The DNA content assay and histological evaluation indicated that cellular and nuclear residues were efficiently eliminated and the AM extracellular matrix component was maintained during decelluarization. DAM matrices were developed as three-dimensional scaffolds and hiPSCs were seeded into these scaffolds in defined induction media. In dAM scaffolds, hiPSCs-HLCs gradually took a typical shape of hepatocytes (polygonal morphology). HiPSCs-HLCs that were cultured into dAM scaffolds showed a higher level of hepatic markers than those cultured in tissue culture plates (TCPs). Moreover, functional activities in term of albumin and urea synthesis and CYP3A activity were significantly higher in dAM scaffolds than TCPs over the same differentiation period. Thus, based on our results, dAM scaffold might have a considerable potential in liver tissue engineering, because it can improve hepatic differentiation of hiPSCs which exhibited higher level of the hepatic marker and more stable metabolic functions. 相似文献
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Ali Pormohammad Naser Mohtavinejad Pourya Gholizadeh Hossein Dabiri Alireza Salimi Chirani Ali Hashemi Mohammad Javad Nasiri 《Journal of cellular physiology》2019,234(2):1208-1218
There is information regarding the rates of gastric cancer (GC) in different populations and the important role of Helicobacter pylori in GC development; however, no comprehensive study has yet been performed to investigate the prevalence of GC in H. pylori–infected patients. PubMed, Embase, and Cochrane Library through January 1, 2000 were searched without language restrictions. Quality of included studies was assessed with a critical appraisal checklist recommended by the Joanna Briggs Institute. All of the analyses were conducted using Comprehensive Meta-Analysis Software Version 2.0 and Stata 14.0. Forty-four studies from 17 countries were included. The pooled frequency of GC was 17.4% (95% confidence interval: 16.4–18.5) in H. pylori–infected population. The frequency of GC among H. pylori–infected population varied markedly across countries. The highest rate of GC was observed in H. pylori–infected individuals from Asian countries. The frequency of GC was relatively high in H. pylori–infected population in the world. However, the eradication of H. pylori might be a promising strategy for GC prevention, especially in high-risk populations such as Asian countries. 相似文献
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Farzad Rahmani Forouzan Amerizadeh Seyed Mahdi Hassanian Milad Hashemzehi Seyedeh-Najibeh Nasiri Hamid Fiuji Gordon A. Ferns Majid Khazaei Amir Avan 《Journal of cellular physiology》2019,234(8):14123-14132
The Wnt/β-catenin pathway is one of the most common pathways dysregulated in breast cancer, and may, therefore, be a potential-therapeutic target. We have investigated the effects of PNU-74654 in breast cancer, as a Wnt/β-catenin inhibitor, either alone or in combination with fluorouracil (5-FU). PNU-74654 suppressed cell growth at an IC 50 of 122 ± 0.4 μmol/L and synergistically enhanced the antiproliferative activity of gemcitabine by modulating the Wnt pathway. Using a 3D cell culture model, we found that the PNU-74654 caused tumor shrinkage. It reduced the migration of MCF-7 cells (by an 18% reduction in invasive behavior) after the treatment with PNU-74654 through perturbation of E-cadherin and MMP3/9. PNU-74654/5-FU combination enhanced the percentages of cells in S-phase and significantly increased apoptosis. Moreover, our data showed that this agent was able to inhibit the growth of tumor in a xenograft model, although this effect was more pronounced in the animals treated with PNU-74654 plus 5-FU. These data show the ability of PNU-74654 to specifically target Wnt pathway, interfere with cell proliferation, induce-apoptosis, reduce-migration, and synergistically interact with 5-FU, supporting further studies on this novel therapeutic-approach for breast cancer. 相似文献
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Rommasi Foad Nasiri Mohammad Javad Mirsaeidi Mehdi 《Molecular and cellular biochemistry》2022,477(3):711-726
Molecular and Cellular Biochemistry - The novel coronavirus pandemic has emerged as one of the significant medical-health challenges of the current century. The World Health Organization has named... 相似文献
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Bakhshalizadeh S Esmaeili F Houshmand F Shirzad H Saedi M 《In vitro cellular & developmental biology. Animal》2011,47(8):550-557
Selegiline, the irreversible inhibitor of monoamine oxidase B (MAO-B), is currently used to treat Parkinson’s disease. However,
the mechanism of action of selegiline is complex and cannot be explained solely by its MAO-B inhibitory action. It stimulates
gene expression, as well as expression of a number of mRNAs or proteins in nerve and glial cells. Direct neuroprotective and
anti-apoptotic actions of selegiline have previously been observed in vitro. Previous studies showed that selegiline can induce
neuronal phenotype in cultured bone marrow stem cells and embryonic stem cells. Embryonal carcinoma (EC) cells are developmentaly
pluripotene cells which can be differentiated into all cell types under the appropriate conditions. The present study was
carried out to examine the effects of selegiline on undifferentiated P19 EC cells. The results showed that selegiline treatment
had a dramatic effect on neuronal morphology. It induced the differentiation of EC cells into neuron-like cells in a concentration-dependent
manner. The peak response was in a dose of selegiline significantly lower than required for MAO-B inhibition. The differentiated
cells were immunoreactive for neuron-specific proteins, synaptophysin, and β-III tubulin. Stem cell therapy has been considered
as an ideal option for the treatment of neurodegenerative diseases. Generation of neurons from stem cells could serve as a
source for potential cell therapy. This study suggests the potential use of combined selegiline and stem cell therapy to improve
deficits in neurodegenerative diseases. 相似文献