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Mohamed A. Farag Dalia A. Al‐Mahdy Riham Salah El Dine Sherifa Fahmy Aymen Yassin Andrea Porzel Wolfgang Brandt 《化学与生物多样性》2015,12(6):955-962
Bacterial wilts of potato, tomato, pepper, and or eggplant caused by Ralstonia solanacearum are among the most serious plant diseases worldwide. In this study, the issue of developing bactericidal agents from natural sources against R. solanacearum derived from plant extracts was addressed. Extracts prepared from 25 plant species with antiseptic relevance in Egyptian folk medicine were screened for their antimicrobial properties against the potato pathogen R. solancearum by using the disc‐zone inhibition assay and microtitre plate dilution method. Plants exhibiting notable antimicrobial activities against the tested pathogen include extracts from Acacia arabica and Punica granatum. Bioactivity‐guided fractionation of A. arabica and P. granatum resulted in the isolation of bioactive compounds 3,5‐dihydroxy‐4‐methoxybenzoic acid and gallic acid, in addition to epicatechin. All isolates displayed significant antimicrobial activities against R. solanacearum (MIC values 0.5–9 mg/ml), with 3,5‐dihydroxy‐4‐methoxybenzoic acid being the most effective one with a MIC value of 0.47 mg/ml. We further performed a structure–activity relationship (SAR) study for the inhibition of R. solanacearum growth by ten natural, structurally related benzoic acids. 相似文献
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Background
Bacterial meningitis is often associated with cerebral compromise which may be responsible for neurological sequelae in nearly half of the survivors. Little is known about the mechanisms of CNS involvement in bacterial meningitis. Several studies have provided substantial evidence for the key role of nitric oxide (NO) and reactive oxygen species in the complex pathophysiology of bacterial meningitis. 相似文献3.
Galal E. H. Elgemeie Adel M. E. Attia Sherifa S. Alkabai 《Nucleosides, nucleotides & nucleic acids》2013,32(4):723-733
Abstract A novel synthesis of condensed bicyclic thiopyrimidine glycosides utilising 1H-cyclopentapyrimidine-2(3H)-thiones and α-bromoglucose or α-bromogalactose tetraacetate as starting components is described. 相似文献
4.
Sherifa A Hamed 《BMC neurology》2010,10(1):2
Background
Abdominal migraine is a commonly described migraine variant in children and young adults, but associations with Alice in Wonderland syndrome and lilliputian hallucinations are exceptional. 相似文献5.
Sherifa Fathalla Dawoud Tarek Mostafa Al-Akra Amina Mohamed Zedan 《Reports of Biochemistry & Molecular Biology》2021,10(3):506
Background:Emamectin benzoate (EMB) is a biopesticide which used in agriculture as an insecticide. It is easier to reach ecologically and affects human health. This study aims to evaluate the protective effect of chitosan and chitosan nanoparticles against EMB-induced hepatotoxicity.Methods:Male mice were distributed into four groups: G1: the negative control, G2: EMB group (5 mg/kg diet), G3: EMB with Chitosan, (600 mg/kg diet), and G4: EMB with Chitosan nanoparticles (600 mg/kg diet). The experiment continues for 8 weeks, and the animals were sacrificed, and their organs were removed and immediately weighed after sacrifice. The liver was quickly removed and processed for histopathological and genetic studies.Results:Emamectin benzoate (EMB) treatment induced oxidative stress by increased levels of Malondialdehyde (MDA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with inhibition of acetylcholinesterase (AChE), Superoxide dismutase (SOD) and Catalase (CAT) levels. EMB produced several histopathological changes in the liver. Relative expressions of studied genes elevated in the liver with increase in DNA damage. Co-treatment with chitosan and chitosan nanoparticles reduced EMB related liver toxicity that belong to biochemical, histopathological, gene expression, and DNA damage by increasing antioxidant capacity.Conclusion:This study offers insight into the potential for Chitosan and chitosan nanoparticles as a novel natural material against the oxidative stress induced by EMB.Key Words: Chitosan Nanoparticles, DNA Fragmentation, Emamectin Benzoate, Gene Expression, Hepatotoxicity 相似文献
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Essawy AE Abdelmeguied NE Radwan MA Hamed SS Hegazy AE 《Cell biology and toxicology》2009,25(3):275-290
The present study was designed to investigate the neuropathological effect of the two carbamate pesticides: methomyl and methiocarb
on the neurons of the buccal ganglia in the land snail Eobania vermiculata using topical application and baiting technique. Their in vivo effects on acetylcholinesterase (AChE, EC 3.1.1.7) activity
were also investigated. Sublethal dose and concentration (1/4 LD50 and 1/4 LC50) of both pesticides were used, and the experiment lasted for 14 days. Histopathological and ultrastuctural alterations in
the buccal ganglia were more obvious after the baiting technique treatment than after the topical application method, and
methomyl was found to be more toxic than methiocarb. These alterations included shrinkage of the perikarya of neurons, increased
cytoplasmic basophilia, and extreme indentation of the plasma membrane. In addition, the nuclei appeared karyolitic, eccentric,
and highly shrunken with an irregular nuclear envelope. The most outstanding symptom observed after topical application of
methiocarb was a highly vacuolated cytoplasm with a peripheral increase in electron density associated with dense accumulations
of free ribosomes. On the other hand, an increased number of lysosomes and autophagosomes were observed after topical application
of methomyl. Mitochondrial damage, increased number of lipid droplets, and myelin figures were frequently observed in ganglia
treated with either methomyl or methiocarb. Moreover, it was noticed that both compounds induced reductions in AChE activity.
However, methomyl exhibited more potency in reducing AChE activity than methiocarb. 相似文献
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Khadiga G. Adham Hania M. Ibrahim Sherifa S. Hamed Ramadan A. Saleh 《Aquatic Ecology》2002,36(4):549-557
The present study is an attempt to relate environmental factors ofambient water to the physiology of the cichlid, Oreochromisniloticus. Fish were collected at 3 stations along Lake Maryûtand a fourth one in an authorized hatchery as reference. Water analysis showedthat many attributes of the water quality, in particular in the main basin,werefar beyond admissible levels. In response, functional damage of the heart andliver in polluted fish was pointed out in view of the elevated serum enzymes(alanine aminotransferase, lactate dehydrogenase, creatine kinase, alkalinephosphatase and cholinesterase). Alkaline phosphatase seemed to potentiallyindicate excess phosphate in ambient water, whereas, aspartate aminotransferasewas suppressed in fish caught from waters with the highest metalconcentrations.Serologic data of carbohydrate, lipid and protein metabolites drew attention tothe adverse effects on liver, heart and kidney functions of industrial andmunicipal discharges into the fishes habitats. 相似文献
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Sabah Ansar Manal Abudawood Sherifa Shaker Hamed Mukhtar M. Aleem 《Biological trace element research》2017,175(2):360-366
Zinc oxide nanoparticles (ZnONPs) are widely used in food packaging and may enter the body directly if exposed. Hereby, in this study, the oral administration was selected as the route of exposure for rats to nanoparticles and the effect of hesperidin (HSP, 100 mg/kg bwt) was evaluated on ZnONP (600 mg/kg bwt)-induced neurotoxicity in rats. ZnONPs were characterized using transmission electron microscopy. Neurotoxicity was observed as seen by elevation in serum inflammatory markers including tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1β), interleukin-6 (IL-6), C-reactive protein (CRP), and activities of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH) content in rat brains. Pretreatment of rats with HSP in ZnONP-treated group elevated activities of antioxidant enzymes. HSP also caused decrease in TNF-α, IL-1β, IL-6, and CRP levels which was higher in the ZnONP-treated group. The results suggest that HSP augments antioxidant defense with anti-inflammatory response against ZnONP-induced neurotoxicity. The increased antioxidant enzymes enhance the antioxidant potential to reduce oxidative stress. 相似文献
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Xiaopeng Sun Belal Amany Elanany Mohamed A. Alsantali Reem I. Alrooqi Munira M. Mohamed Abdalla R. Hasabelnaby Sherifa 《Russian Journal of Bioorganic Chemistry》2022,48(2):438-456
Russian Journal of Bioorganic Chemistry - Rhinitis is an allergic disease that causes troubles and restlessness for patients. In this research work we will focus on finding promising organic... 相似文献
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