全文获取类型
收费全文 | 162篇 |
免费 | 6篇 |
出版年
2021年 | 5篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 9篇 |
2017年 | 7篇 |
2016年 | 5篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2013年 | 6篇 |
2012年 | 7篇 |
2011年 | 5篇 |
2010年 | 12篇 |
2009年 | 5篇 |
2008年 | 7篇 |
2007年 | 10篇 |
2006年 | 11篇 |
2005年 | 3篇 |
2004年 | 12篇 |
2003年 | 4篇 |
2002年 | 9篇 |
2001年 | 4篇 |
2000年 | 6篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 7篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有168条查询结果,搜索用时 31 毫秒
1.
Vilchinskaya N. A. Shenkman B. S. 《Journal of Evolutionary Biochemistry and Physiology》2021,57(4):852-861
Journal of Evolutionary Biochemistry and Physiology - Skeletal muscles are well known to have a high degree of plasticity. Gravitational unloading has a strong impact on the structural and... 相似文献
2.
BS Sabna Thankappan Bency Mahendran Ramasamy Muthusamy Gayathri Femil selta Daniel Raja Angayarkanni Jayaraman 《Probiotics and antimicrobial proteins》2021,13(4):993-1004
Probiotics and Antimicrobial Proteins - Gamma-aminobutyric acid (GABA) is a principal inhibitory neurotransmitter in the central nervous system and is produced by irreversible decarboxylation of... 相似文献
3.
Marina Shenkman Bella Groisman Efrat Ron Edward Avezov Linda M. Hendershot Gerardo Z. Lederkremer 《The Journal of biological chemistry》2013,288(4):2167-2178
Studies of misfolded protein targeting to endoplasmic reticulum-associated degradation (ERAD) have largely focused on glycoproteins, which include the bulk of the secretory proteins. Mechanisms of targeting of nonglycosylated proteins are less clear. Here, we studied three nonglycosylated proteins and analyzed their use of known glycoprotein quality control and ERAD components. Similar to an established glycosylated ERAD substrate, the uncleaved precursor of asialoglycoprotein receptor H2a, its nonglycosylated mutant, makes use of calnexin, EDEM1, and HRD1, but only glycosylated H2a is a substrate for the cytosolic SCFFbs2 E3 ubiquitin ligase with lectin activity. Two nonglycosylated BiP substrates, NS-1κ light chain and truncated Igγ heavy chain, interact with the ERAD complex lectins OS-9 and XTP3-B and require EDEM1 for degradation. EDEM1 associates through a region outside of its mannosidase-like domain with the nonglycosylated proteins. Similar to glycosylated substrates, proteasomal inhibition induced accumulation of the nonglycosylated proteins and ERAD machinery in the endoplasmic reticulum-derived quality control compartment. Our results suggest a shared ERAD pathway for glycosylated and nonglycosylated proteins composed of luminal lectin machinery components also capable of protein-protein interactions. 相似文献
4.
B.?S.?Shenkman O.?E.?Zinovyeva S.?P.?Belova N.?D.?Samkhaeva N.?S.?Shcheglova T.?M.?Mirzoev N.?A.?Vilchinskaya E.?G.?Altaeva O.?V.?Turtikova T.?L.?NemirovskayaEmail author 《Biophysics》2016,61(5):793-796
A gender analysis has been carried out to analyze changes in intracellular signaling pathways that lead to the development of chronic alcoholic myopathy. It is known that acute or chronic alcohol intoxication can result in alcohol-induced lesions in skeletal muscles. Chronic alcoholic myopathy occurs much more frequently and can develop either independently or in combination with other forms of alcoholic disease (liver and heart lesions, malabsorption syndrome, or alcohol polyneuropathy). This disease is manifested by atrophy of skeletal muscles and a performance decrement. Most of the studies on the pathogenesis of chronic alcoholic myopathy have been carried out on male patients. Studies on alcoholic myopathy-induced muscle damage in females have not been previously reported. 相似文献
5.
PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress 总被引:3,自引:0,他引:3
Kondratyev M Avezov E Shenkman M Groisman B Lederkremer GZ 《Experimental cell research》2007,313(16):3395-3407
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the ER membrane kinases PERK and IRE1 leading to the unfolded protein response (UPR). We show here that UPR activation triggers PERK and IRE1 segregation from BiP and their sorting with misfolded proteins to the ER-derived quality control compartment (ERQC), a pericentriolar compartment that we had identified previously. PERK phosphorylates translation factor eIF2alpha, which then accumulates on the cytosolic side of the ERQC. Dominant negative PERK or eIF2alpha(S51A) mutants prevent the compartmentalization, whereas eIF2alpha(S51D) mutant, which mimics constitutive phosphorylation, promotes it. This suggests a feedback loop where eIF2alpha phosphorylation causes pericentriolar concentration at the ERQC, which in turn amplifies the UPR. ER-associated degradation (ERAD) is an UPR-dependent process; we also find that ERAD components (Sec61beta, HRD1, p97/VCP, ubiquitin) are recruited to the ERQC, making it a likely site for retrotranslocation. In addition, we show that autophagy, suggested to play a role in elimination of aggregated proteins, is unrelated to protein accumulation in the ERQC. 相似文献
6.
Grigor'ev AI Kozlovskaia IB Shenkman BS 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2004,90(5):508-521
Results of experimental studies are reviewed that point out to the leading role of the support afferents in control of structural-functional properties of the tonic muscle system. It is shown that the support afferents play a role of the trigger in the postural system, the trigger enhancing (when the support is present) or inhibiting (when the support is withdrawn) the activity of tonic motor units (MU's). Under the absence of support condition, recorded in extensors are: an obvious decline of the muscle stiffness and the maximal voluntary force; a significant decrease of the absolute force of the isometric contraction of single skin muscle fibers evoked by Ca++; a prominent decline of the tonic muscle fibers transversal size; and the transformation of the myosin phenotype from slow to fast one. Mechanical stimulation of the support zones of soles in the regimes of locomotion (slow and fast stepping) under the absence of support condition eliminates all the above effects. 相似文献
7.
Moukhina A Shenkman B Blottner D Nemirovskaya T Lemesheva Y Püttmann B Kozlovskaya I 《Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology》2004,11(2):P137-P138
In this study the model of 7-day dry immersion (DI) was used. 17 male volunteers (23-29 years old) were divided in 2 groups: (i) 7-day DI without support (DI, n=9), (ii) 7-day DI using support stimulation (DIS, n=8). Support stimulator device exerted pressure of 0.2 +/- 0.15 kg/cm2 upon the plantar support zones simulating the walking pattern 6 times a day for 20 minutes of every hour: 10 minutes at a speed of 75 steps/min and 10 minutes at a speed of 120 steps/min. M. soleus biopsy was performed before and immediately after DI. The m. soleus fiber myosin heavy chain (MHC) profile, myofiber cross-sectional area (CSA) and total protein concentration were analyzed in frozen serial sections. In addition, NO-synthase 1 (NOS1) levels indicative of normal muscle cell signaling were analyzed by western blotting in 4 persons in each group. After dry immersion, percentage of muscle fibers containing type I MHC decreased by 6% (p<0.05) in group DI, but was not changed significantly in group DIS. Percentage of the type IIa fibers was significantly altered in none of the groups. Type I fiber CSA decreased by 24.4% (p<0.05) in group DI. No significant changes of type I fiber CSA were found in group DIS. CSA of the type IIa fibers significantly altered in none of the groups. The total protein concentration was found increased by 17.6% in group DI and by 21% in group DIS. The increased total protein content in group DI suggests a diminution of fiber CSA attributed to the loss of non-protein component of fibers. NOS1 decreased by 35.6% in group DI and increased by 58.1% in group DIS. We conclude that 7 days in dry immersion lead to reduction in the type I muscle fiber percentage, loss of the non-protein component and decline in NOS1. These changes were clearly prevented by the support stimulation protocol applied during the DI period. 相似文献
8.
Shenkman BS Belozerova IN Nemirovskaya TL Goncharova SA Strogonova LB 《Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology》2001,8(1):P75-P76
Intensive muscle tension induces significant blood accumulation of enzymes and structural proteins of the muscle origin. Altered macromolecular permeability of the sarcolemma is attributed to integrity of sarcolemmal cytoskeleton, mainly to dystrophin-sarcoglycan (DSG) complex. It is known that intensive tension of the antigravity extensor muscles is observed under conditions of gravitational overloading. We assumed that acute exposure to hypergravity would lead to serum accumulation of creatine phosphokinase (CK) associated with considerably altered integrity of the dystrophin layer in fibers of extensor muscles. 相似文献
9.
Shenkman BS Belozerova IN Lee P Nemirovskaia TL Kozlovskaia IB 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2002,88(3):340-347
After staying in real and simulated weightlessness, the most obvious changes were recorded in the "slow" tonic muscles like m. soleus, the protein loss in the fibres being greater than the loss of other components, water included. 相似文献