Combined Effect of Neutron and Proton Radiations on the Growth of Solid Ehrlich Ascites Carcinoma and Remote Effects in Mice

Doklady Biochemistry and Biophysics - The combined effect of the irradiation with a proton pencil scanning beam (PBS) at a total dose of 80 Gy and neutron radiation at a dose of 5 Gy on the growth...     

Assessment of the Relative Biological Efficiency of Pencil Beam Scanning of Protons in Mice in Vivo

Doklady Biochemistry and Biophysics - The effect of proton pencil beam scanning in the dose range of 4.5–15 Gy on the radiosensitivity of mice under irradiation in two regions of the Bragg...     

The remote effects of radiation after hypofractionated irradiation with protons of Ehrlich ascites carcinoma in mice

This work focuses on the study of remote effects (duration of remission, recurrence rate, and average lifespan) in mice with Ehrlich ascites carcinoma exposed to oligofractionated irradiation with a pencil scanning beam of protons depending on the volume of the tissue being irradiated and the interval between dose fractions. The results show higher antitumor efficacy and a considerable increase in the average life span of mice after hypofractionated irradiation with a pencil scanning beam of protons at a total dose of 60 Gy of the gross tumor volume compared with the planning target volume.     

The combined effects of dietary supplements and low-dose-rate high-LET radiation on mice in vivo

The purpose of this study was to investigate the combined actions of food supplements and lowdose-rate high-LET radiation on radiosensitivity, induction of the adaptive response, and tumor growth in SHK mice in vivo. The animals were irradiated with 0.11 Gy (0.005 Gy/day) of low-dose-rate high-LET radiation behind the concrete shield of a 70 GeV proton accelerator (Protvino, Moscow oblast). Four groups of the mice were fed with selected products (soy meat, buckwheat, lettuce leaves, and a drug based on cod-liver oil) during the entire irradiation period (22 days). The results of the study indicate that the mice with diets containing soy meat, buckwheat, and lettuce leaves in contrast to those fed with a diet containing cod-liver oil had reduced sensitivity to X-radiation at a dose rate of 1.5 Gy and a significant slowdown in the growth of the Ehrlich carcinoma. The combined effect of high-LET radiation and the food supplements mentioned above (except for the cod-liver oil) reduced the sensitivity of the mice to the irradiation at a dose rate of 1.5 Gy, induced the adaptive response, and caused a decrease in the growth rate of the Ehrlich carcinoma in contrast to the mice that were only irradiated with high-LET radiation.     

Hypofractionated irradiation of the solid form of Ehrlich ascites carcinoma in mice by a thin scanning proton beam

The dynamics of the growth of Ehrlich ascites carcinoma in mice of the SHK line exposed to hypofractionated high-dose irradiation by a thin scanning proton beam has been analyzed for different irradiation volumes and different time intervals (from 4 to 24 hours) between two 30-Gy fractions. Irradiation of the gross tumor volume and the planned target volume was performed within the Bragg peak; the energy of protons at the outlet of the accelerator ranged from 85 to 100 MeV. Hypofractionated irradiation of the gross tumor volume of Ehrlich ascites carcinoma resulted in a more pronounced antitumor effect than the irradiation of the planned target volume. The effect did not depend on the interval between the irradiation episodes.     

Age-related changes in lipid peroxidation in various structures of the central nervous system

Age-related changes in contents of lipid peroxidation (LPO) products and sensitivity to oxidative stress were studied in ten structures of the human brain and three parts of the spinal cord. LPO was found to increase with age in all parts of the central nervous system. This regularity was especially pronounced in the brainstem structures (the hypothalamus, mesencephalon, and myelencephalon) and in the cervical and sacrolumbar enlargements of the spinal cord.Translated from Fiziologiya Cheloveka, Vol. 31, No. 2, 2005, pp. 108–115.Original Russian Text Copyright © 2005 by Volchegorskii, Shemyakov, Telesheva, Malinovskaya, Turygin.     

The Effect of Irradiation with a Sequence of Neutrons and Protons on the Tumor Response of Solid Ehrlich Carcinoma and Skin Reactions in Mice in the Early and Long Terms

Biophysics - The effects of combined irradiation with a sequence of protons at a total dose of 80 Gy and neutrons at a dose of 5 Gy of a solid form of ascitic Ehrlich carcinoma on the response of...