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排序方式: 共有71条查询结果,搜索用时 31 毫秒
1.
A. Yu. Tsibulevsky T. K. Dubovaya A. I. Shchegolev A. I. Sergeev A. V. Bykov Kh. K. Gadzhieva 《Biology Bulletin》2005,32(6):590-596
Intoxication with bacterial lipopolysaccharide (endotoxin) is accompanied by considerable rearrangements in the systems of blood microcirculation and water metabolism of the liver. These rearrangements are manifested as increased sinusoid area, changed total area of the cytoplasm and nuclei as well as the nucleocytoplasmic ratio in hepatocytes, increased content of total water in the organ, and changed magnetic relaxation properties (spin-lattice and spin-spin relaxation times). Preliminary parasympathetic denervation of the liver (vagotomy) changes the pattern of the organ response to bacterial endotoxin poisoning as indicated by the kinetics of studied morphological and biophysical parameters. 相似文献
2.
Medvedeva A. V. Rebrova A. V. Zalomaeva E. S. Turaeva S. K. Nikitina E. A. Tokmacheva E. V. Vasileva S. A. Shchegolev B. F. Savvateeva-Popova E. V. 《Journal of Evolutionary Biochemistry and Physiology》2022,58(1):35-44
Journal of Evolutionary Biochemistry and Physiology - The paper continues the cycle of studies on the evolutionary link between the mechanisms of stress response formation and cognitive functions... 相似文献
3.
Zhuravlev AV Zakharov GA Shchegolev BF Savvateeva-Popova EV 《Journal of molecular modeling》2012,18(5):1755-1766
Stacking interaction is known to play an important role in protein folding, enzyme-substrate and ligand-receptor complex formation.
It has been shown to make a contribution into the aromatic antagonists binding with glutamate ionotropic receptors (iGluRs),
in particular, the complex of NMDA receptor NR1 subunit with the kynurenic acid (KYNA) derivatives. The specificity of KYNA
binding to the glutamate receptors subtypes might partially result from the differences in stacking interaction. We have calculated
the optimal geometry and binding energy of KYNA dimers with the four types of aromatic amino acid residues in Rattus and Drosophila ionotropic iGluR subunits. All ab initio quantum chemical calculations were performed taking into account electron correlations
at MP2 and MP4 perturbation theory levels. We have also investigated the potential energy surfaces (PES) of stacking and hydrogen
bonds (HBs) within the receptor binding site and calculated the free energy of the ligand-receptor complex formation. The
energy of stacking interaction depends both on the size of aromatic moieties and the electrostatic effects. The distribution
of charges was shown to determine the geometry of polar aromatic ring dimers. Presumably, stacking interaction is important
at the first stage of ligand binding when HBs are weak. The freedom of ligand movements and rotation within receptor site
provides the precise tuning of the HBs pattern, while the incorrect stacking binding prohibits the ligand-receptor complex
formation. 相似文献
4.
Basing on the data obtained at early autopsies, we compared the structure and metabolism of liver acini in acute blood loss and pulmonary artery thromboembolism. Morpho- and pathogenetic impairment of hepatocytes of various acinic zones was correlated and studied histo-enzymatically. 相似文献
5.
Immunochemical reactivity of O-specific polysaccharide and the monosaccharide composition of O-antigenic determinants of the lipopolysaccharide isolated from the type strain Sp7 of Azospirillum brasilense were studied. An original modification of the method of spectroturbidimetry for disperse biological systems and a nonstandard procedure for the preparation of monospecific antibodies against cell surface antigens were used. The polysaccharide fraction, which contained residues of galactose, rhamnose, and galacturonic acid, was able to bind about 50% of the antibodies raised against whole bacterial cells. Twelve immunodeterminant groups were shown to be present in its molecule. Galactose and, less effectively, rhamnose but not galacturonic acid inhibited the antigen-antibody reactions. It is concluded that the serotype of the strain studied is determined by galactose residues. 相似文献
6.
Guliy O. I. Markina L. N. Ignatov O. V. Shchegolev S. Yu. Zaitseva I. S. Bunin V. D. Ignatov V. V. 《Microbiology》2005,74(1):111-115
The study of the effect of ampicillin on the electrophysical properties of Escherichia coli cells showed that this antibiotic influences the orientational spectra (OSs) of the ampicillin-susceptible E. coli strains K-12 and XL-1 within the frequency range 10–1000 kHz of the orienting electric field and does not affect the OSs of the ampicillin-resistant strains K-12(pUC-18) and XL-1(pHEN1). The change in the electrooptical signal of the ampicillin-susceptible cells was maximum at an ampicillin concentration of 50 µg/ml and did not depend on the exposure time. The conclusion is drawn that changes in the OSs of cells can be used to evaluate their resistance to ampicillin.Translated from Mikrobiologiya, Vol. 74, No. 1, 2005, pp. 126–131.Original Russian Text Copyright © 2005 by Guliy, Markina, Ignatov, Shchegolev, Zaitseva, Bunin, Ignatov. 相似文献
7.
A. D. Melnik N. N. Bakharev V. K. Gusev P. R. Goncharov G. S. Kurskiev V. B. Minaev Yu. V. Petrov N. V. Sakharov A. Yu. Telnova S. Yu. Tolstyakov F. V. Chernyshev P. B. Shchegolev 《Plasma Physics Reports》2017,43(8):805-817
Specific features of the energy distributions of fast ions during neutral beam injection at the Globus-М tokamak are considered. Different loss mechanisms that can lead to the formation of a specific shape of the energy spectrum of superthermal ions are analyzed. The effect of sawtooth oscillations on the loss of fast ions is discussed. 相似文献
8.
A. D. Iblyaminova G. F. Avdeeva P. N. Aruev N. N. Bakharev V. K. Gusev V. V. Zabrodsky G. S. Kurskiev V. B. Minaev I. V. Miroshnikov M. I. Patrov Yu. V. Petrov N. V. Sakharov S. Yu. Tolstyakov P. B. Shchegolev 《Plasma Physics Reports》2016,42(10):909-918
Radiation losses from the plasma of the Globus-M tokamak are studied by means of SPD silicon photodiodes developed at the Ioffe Institute, Russian Academy of Sciences. The results from measurements of radiation losses in regimes with ohmic and neutral beam injection heating of plasmas with different isotope compositions are presented. The dependence of the radiation loss power on the plasma current and plasma–wall distance is investigated. The radiation power in different spectral ranges is analyzed by means of an SPD spectrometric module. Results of measurements of radiation losses before and after tokamak vessel boronization are presented. The time evolution of the sensitivity of the SPD photodiode during its two-year exploitation in Globus-M is analyzed. 相似文献
9.
The influence of Earth magnetic field shielded down to 0.3 μT and static magnetic field (60–160 μT) on the proliferation and
differentiation of satellite muscle cells in primary culture has been investigated. A stimulatory effect of static magnetic
fields on the rate of the formation of massive multinucleate myotubes and an increase in the intracellular calcium concentration
([Ca2+]
i
) have been detected for magnetic fields of the microtesla range. On the other hand, it was shown that the reduction of earth
magnetic fields to 0.3 μT leads to inhibition of proliferation and differentiation of skeletal muscle cells in primary culture.
Since the formation of contractile myotubes during in vitro experiments is similar to the regeneration of skeletal muscle
fibers under muscle damage in vivo, it may be concluded that weak magnetic fields have a strong effect on intracellular processes
by influencing all phases of muscle fiber formation. It is necessary to take this fact into consideration when forecasting
probable complications of skeletal muscle regeneration during long-term exposure of man to low-intensity magnetic fields and
also for the potential use of low static magnetic fields as a tool to recover the affected myogenesis. 相似文献
10.
Biophysics - Abstract—This work was aimed at studying the effects of weak geomagnetic disturbances on systolic blood pressure, the R–R interval, the low-frequency and high-frequency... 相似文献