全文获取类型
收费全文 | 6023篇 |
免费 | 599篇 |
专业分类
6622篇 |
出版年
2022年 | 44篇 |
2021年 | 75篇 |
2020年 | 38篇 |
2019年 | 61篇 |
2018年 | 69篇 |
2017年 | 64篇 |
2016年 | 105篇 |
2015年 | 168篇 |
2014年 | 200篇 |
2013年 | 265篇 |
2012年 | 295篇 |
2011年 | 330篇 |
2010年 | 236篇 |
2009年 | 187篇 |
2008年 | 298篇 |
2007年 | 302篇 |
2006年 | 277篇 |
2005年 | 255篇 |
2004年 | 267篇 |
2003年 | 261篇 |
2002年 | 235篇 |
2001年 | 130篇 |
2000年 | 114篇 |
1999年 | 117篇 |
1998年 | 100篇 |
1997年 | 59篇 |
1996年 | 69篇 |
1995年 | 56篇 |
1994年 | 57篇 |
1993年 | 64篇 |
1992年 | 76篇 |
1991年 | 89篇 |
1990年 | 84篇 |
1989年 | 48篇 |
1988年 | 85篇 |
1987年 | 56篇 |
1986年 | 51篇 |
1985年 | 76篇 |
1984年 | 58篇 |
1983年 | 48篇 |
1982年 | 55篇 |
1981年 | 50篇 |
1980年 | 45篇 |
1979年 | 41篇 |
1977年 | 50篇 |
1976年 | 44篇 |
1975年 | 40篇 |
1974年 | 49篇 |
1972年 | 43篇 |
1968年 | 37篇 |
排序方式: 共有6622条查询结果,搜索用时 0 毫秒
1.
2.
The Vascular System of Maize Stems Revisited: Implications for Water Transport and Xylem Safety 总被引:3,自引:0,他引:3
The plexus of vascular bundles in the nodes of grasses is notoriouslycomplex, where long axial bundles pass through a network oftransverse bundles. The xylem pathways for water in maize stemshave been investigated anatomically and with dye and particulatetracers, revealing some of the details of this complexity. Onlyapprox. 3% of axial vessels pass through nodes without beinginterrupted by end walls. Axial bundles at nodes differ fromthose in internodes in having the metaxylem and protoxylem vesselsconnected by small tracheary elements. So it is only at nodesthat exchange of sap occurs between the large vessels withina bundle. End walls, acting as filters for particles and gasbubbles, always separate axial vessels from vessels in transversebundles. The high redundancy of bundle connections in the nodalplexus is interpreted as providing alternative water pathwaysto bypass embolisms and damaged or diseased sections of thexylem. The pores in the filters at the base of nodes and betweenaxial and transverse vessels within nodes are <20 nm in diameter.Where axial vessels connect to transverse vessels, a varietyof unusual shapes of vessel elements mediate two- and three-wayconnections within the plexus.Copyright 2000 Annals of BotanyCompany Zea mays, cryoSEM, maize, node, pits, pit membranes, vessel ends, vessels, xylem embolism, xylem pathogens 相似文献
3.
4.
Alayna E. Loiselle Shane A. J. Lloyd Emmanuel M. Paul Gregory S. Lewis Henry J. Donahue 《PloS one》2013,8(11)
Connexin 43 (Cx43) is the most abundant gap junction protein in bone and is required for osteoblastic differentiation and bone homeostasis. During fracture healing, Cx43 is abundantly expressed in osteoblasts and osteocytes, while Cx43 deficiency impairs bone formation and healing. In the present study we selectively deleted Cx43 in the osteoblastic lineage from immature osteoblasts through osteocytes and tested the hypothesis that Cx43 deficiency results in delayed osteoblastic differentiation and impaired restoration of biomechanical properties due to attenuated β-catenin expression relative to wild type littermates. Here we show that Cx43 deficiency results in alterations in the mineralization and remodeling phases of healing. In Cx43 deficient fractures the mineralization phase is marked by delayed expression of osteogenic genes. Additionally, the decrease in the RankL/ Opg ratio, osteoclast number and osteoclast size suggest decreased osteoclast bone resorption and remodeling. These changes in healing result in functional deficits as shown by a decrease in ultimate torque at failure. Consistent with these impairments in healing, β-catenin expression is attenuated in Cx43 deficient fractures at 14 and 21 days, while Sclerostin (Sost) expression, a negative regulator of bone formation is increased in Cx43cKO fractures at 21 days, as is GSK-3β, a key component of the β-catenin proteasomal degradation complex. Furthermore, we show that alterations in healing in Cx43 deficient fractures can be rescued by inhibiting GSK-3β activity using Lithium Chloride (LiCl). Treatment of Cx43 deficient mice with LiCl restores both normal bone formation and mechanical properties relative to LiCl treated WT fractures. This study suggests that Cx43 is a potential therapeutic target to enhance fracture healing and identifies a previously unknown role for Cx43 in regulating β-catenin expression and thus bone formation during fracture repair. 相似文献
5.
6.
7.
8.
Arnold N. Onyango 《Chemistry and physics of lipids》2012,165(7):777-786
Small reactive carbonyl compounds (RCCs) such as formaldehyde, acetaldehyde, acrolein, crotonaldehyde, glyoxal, methylglyoxal, glycolaldehyde, glycidaldehyde, and 2-butene-1,4-dial are involved in carbonyl and oxidative stress-related physiological disorders. While some evidence indicates that lipid oxidation could be an important source of these compounds in vivo, this has sometimes been doubted because the mechanisms of their formation thereby are poorly understood. Here, representative literature supporting the significant formation of these compounds during lipid oxidation under physiologically relevant conditions are highlighted, and the strengths and weaknesses of previously proposed mechanisms of their formation thereby are considered. In addition, based on the current understanding of lipid oxidation chemistry, some new pathways of their formation are suggested. The suggested pathways also generate 4-hydroxy-2-butenal, a precursor of the carcinogen furan, whose endogenous formation in tissues has hitherto not been seriously considered. 相似文献
9.
10.
The substrate specificity of pig liver folylpolyglutamate synthetase (tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), EC 6.3.2.17) for classical 5,8-dideaza analogues of folic acid, isofolic acid aminopterin and isoaminopterin has been investigated. 5,8-Dideazafolate and 5,8-dideazaaminopterin are very effective substrates with activities approaching those of the best reduced folate substrates. The analogous isofolate analogues are less effective substrates, but still better than folic acid. The 5-chloro substituent is the only modification that consistently increases the on rate, with 5-chloro-5,8-dideazaaminopterin being the most effective substrate found, thus far, for the enzyme. Methylation at positions 9 or 10 generally decreases binding, while 5-methylation increases the binding of 4-oxoquinazolines, but decreases the binding of their 4-amino counterparts. The presence of a formyl group at N9 or N10 has the opposite effect, decreasing the binding of 4-oxo analogues while increasing the rate for 4-amino derivatives. Increases in on rate with methyl, formyl or 4-amino substitutions are only significant when the parent compound is a poor substrate, suggesting that these groups do not interact directly with the enzyme but cause conformational changes in the structure of the substrate that influence binding to the enzyme. 相似文献