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Logunova MA Shakhova MA Andreeva IV Ignat'eva NIu Kanenskiĭ VA Bagratashvili VN 《Biofizika》2008,53(5):902-909
The thermal behavior, birefringence properties, and the biochemical composition of thyroid cartilage tissues have been studied. The hyaline cartilage, which was visualized as a quasi-isotropic medium, was composed of type II collagen, which did not denature at temperatures up to 100 degrees C. However, in hyaline cartilage digested by trypsin, the denaturation of collagen occured at 60 degrees C. Collagen fibers in the perichondrium were composed of type I and II collagen and formed a highly organized anisotropic structure (birefringence about 4.75 x 10(-3)) with a melting temperature of about 65 degrees C. The temperature of collagen denaturation in perichondrium in the whole system perichondrium-hyaline cartilage increased up to 75 degrees C, indicating the immobilization of perichondrium collagen by the extracellular matrix of the hyaline constituent. 相似文献
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Orlova AG Maslennikova AV Golubiatnikov GIu Kamenskiĭ VA Shakhova NM Babaev AA Snopova LB Ivanova IP Plekhanov VI Prianikova TI Turchin IV 《Biofizika》2011,56(2):349-355
The potentialities of diffuse optical spectroscopy for the noninvasive estimation of the oxygen state of experimental tumors have been demonstrated. The distribution of total, oxygenated and deoxygenated hemoglobin, as well as the level oxygen saturation of blood have been shown using two tumor models differing in the histological structure and functional characteristics. The results obtained by the optical method have been verified by immunohistochemical examination of tissue specimens with the exogenous hypoxia marker pimonidazole. 相似文献
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Daniela Lenggenhager Alessandra Curioni-Fontecedro Martina Storz Olga Shakhova Lukas Sommer Daniel S. Widmer Burkhardt Seifert Holger Moch Reinhard Dummer Daniela Mihic-Probst 《Translational oncology》2014,7(2):206-212
Despite existing vaccination strategies targeting TRP-2, its function is not yet fully understood. TRP-2 is an enzyme involved in melanin biosynthesis and therefore discussed as a differentiation antigen. However, in mice Trp-2 was shown to be expressed in melanocyte stem cells of the hair follicle and therefore also considered as an indicator of stemness. A proper understanding of the TRP-2 function is crucial, considering a vaccination targeting cells with stemness properties would be highly effective in contrast to a therapy targeting differentiated melanoma cells.Analysing over 200 melanomas including primaries, partly matched metastases and patients’ cell cultures we show that TRP-2 is correlated with Melan A expression and decreases with tumor progression. In mice it is expressed in differentiated melanocytes as well as in stem cells. Furthermore, we identify a TRP-2 negative, proliferative, hypoxia related cell subpopulation which is significantly associated with tumor thickness and diseases progression. Patients with a higher percentage of those cells have a less favourable tumor specific survival.Our findings underline that TRP-2 is a differentiation antigen, highlighting the importance to combine TRP-2 vaccination with other strategies targeting the aggressive undifferentiated hypoxia related subpopulation. 相似文献
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V. E. Fortov O. S. Vaulina O. F. Petrov I. A. Shakhova A. V. Gavrikov Yu. V. Khrustalev 《Plasma Physics Reports》2006,32(4):323-331
Results are presented from experimental studies of heat transfer in liquid-like plasma-dust structures. The experiments were performed with aluminum oxide grains ~3–5 μm in size in an RF discharge plasma. The heat capacity of the dust grains in plasma is measured. The thermal conductivity and thermal diffusivity of liquid-like plasma-dust structures are deduced under the assumption that the observed temperature gradients and the propagation of a thermal perturbation in a dusty plasma are related to heat conduction within the dust component. The measured temperature dependences of the thermal conductivity and thermal diffusivity are in qualitative agreement with the results of numerical simulations performed in the model of a simple single-atom liquid. It is shown that quantitative discrepancy between the experimental and numerical results is related to the energy loss of dust grains in their collisions with the neutral particles of the ambient gas. 相似文献
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Olga Shakhova Phil Cheng Pravin J. Mishra Daniel Zingg Simon M. Schaefer Julien Debbache Jessica H?usel Claudia Matter Theresa Guo Sean Davis Paul Meltzer Daniela Mihic-Probst Holger Moch Michael Wegner Glenn Merlino Mitchell P. Levesque Reinhard Dummer Raffaella Santoro Paolo Cinelli Lukas Sommer 《PLoS genetics》2015,11(1)
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Aruna Kasoju M Lakshmi Narasu Charuvaka Muvva Bathula VV SubbaRao 《Bioinformation》2012,8(14):684-686
Aflatoxins are polyketide-derived secondary metabolites produced by Aspergillus spp. The toxic effects of aflatoxins have adverse
consequences for human health and agricultural economics. The aflR gene, a regulatory gene for aflatoxin biosynthesis, encodes a
protein containing a zinc-finger DNA-binding motif. AFLR-Protein three-dimensional model was generated using Robetta server.
The modeled AFLR-Protein was further optimization and validation using Rampage. In the simulations, we monitored the
backbone atoms and the C-α-helix of the modeled protein. The low RMSD and the simulation time indicate that, as expected, the
3D structural model of AFLR-protein represents a stable folding conformation. This study paves the way for generating computer
molecular models for proteins whose crystal structures are not available and which would aid in detailed molecular mechanism of
inhibition of aflatoxin. 相似文献
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This is the second communication of a series of publications on Russian studies in the field of optical coherent tomography (OCT), the newest noninvasive highly resolving technology of visualization of the structure of biological tissues. By using the investing tissues as an example, this paper demonstrates the universal types of changes in their optical properties. Optimal images permit differentiate benign and malignant processes with a high degree of diagnostic accuracy. Diverse benign processes occurring in the epithelium are detected on the OCT images as changes in its height, the scattering properties and stroke of a basilar membrane. The absence of any structure on the image is the main OCT criterion for malignancy. The diagnostic efficiency of OCT is high in recognizing neoplasia of various mucous membranes: the sensitivity of the technique is 77-98%; its specificity and diagnostic accuracy are 71-96 and 81-87%, respectively. 相似文献