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Munir Ozturk Mert Metin Volkan Altay Tomonori Kawano Alvina Gul Bengu Turkyilmaz Unal Dilek Unal Rouf Ahmad Bhat Moonisa Aslam Dervash Kristina Toderich Esra Koc Pedro Garcia Caparros leeb Shahzadi 《Phyton》2023,92(1):165-192
Aluminum is an abundant metal in the earth’s crust that turns out to be toxic in acidic environments. Many plants are affected by the presence of aluminum at the whole plant level, at the organ level, and at the cellular level. Tobacco as a cash crop (Nicotiana tabacum L.) is a widely cultivated plant worldwide and is also a good model organism for research. Although there are many articles on Al-phytotoxicity in the literature, reviews on a single species that are economically and scientifically important are limited. In this article, we not only provide the biology associated with tobacco Al-toxicity, but also some essential information regarding the effects of this metal on other plant species (even animals). This review provides information on aluminum localization and uptake process by different staining techniques, as well as the effects of its toxicity at different compartment levels and the physiological consequences derived from them. In addition, molecular studies in recent years have reported specific responses to Al toxicity, such as overexpression of various protective proteins. Besides, this review discusses data on various organelle-based responses, cell death, and other mechanisms, data on tobacco plants and other kingdoms relevant to these studies. 相似文献
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S. Amer Riazuddin Amber Shahzadi Zubair M. Ahmed Radha Ayyagari Virgilio G. Ponferrada Christelle Michiels Marie-Elise Lancelot Idrees A. Nasir Shaheen N. Khan Xiaodong Jiao Sheikh Riazuddin Paul A. Sieving J. Fielding Hejtmancik 《American journal of human genetics》2010,87(4):523-531
Congenital stationary night blindness (CSNB) is a nonprogressive retinal disorder that can be associated with impaired night vision. The last decade has witnessed huge progress in ophthalmic genetics, including the identification of three genes implicated in the pathogenicity of autosomal-recessive CSNB. However, not all patients studied could be associated with mutations in these genes and thus other genes certainly underlie this disorder. Here, we report a large multigeneration family with five affected individuals manifesting symptoms of night blindness. A genome-wide scan localized the disease interval to chromosome 15q, and recombination events in affected individuals refined the critical interval to a 10.41 cM (6.53 Mb) region that harbors SLC24A1, a member of the solute carrier protein superfamily. Sequencing of all the coding exons identified a 2 bp deletion in exon 2: c.1613_1614del, which is predicted to result in a frame shift that leads to premature termination of SLC24A1 (p.F538CfsX23) and segregates with the disorder under an autosomal-recessive model. Expression analysis using mouse ocular tissues shows that Slc24a1 is expressed in the retina around postnatal day 7. In situ and immunohistological studies localized both SLC24A1 and Slc24a1 to the inner segment, outer and inner nuclear layers, and ganglion cells of the retina, respectively. Our data expand the genetic basis of CSNB and highlight the indispensible function of SLC24A1 in retinal function and/or maintenance in humans. 相似文献
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Iram Shahzadi Muhammad Iqbal Rizwan Rasheed M. Arslan Ashraf Shagufta Perveen Makhdoom Hussain 《Acta Physiologiae Plantarum》2017,39(8):173
The study was conducted to assess whether selenium (Se) application modulates fertility to alter grain yield in bread wheat grown under different moisture regimes. Seeds of wheat cultivar Millat-2011 were sown in the plots using a randomized complete block design with three replicates per treatment. After germination, the plants were exposed to six moisture regimes, viz. no irrigation after germination, irrigation at boot stage, irrigations at boot and grain-filling stages, irrigations at crown root, boot and grain-filling stages, irrigations at crown root, boot, heading and grain-filling stages and irrigations at crown root, stem elongation, boot, heading and grain-filling stages. At the heading stage, foliar spray of sodium selenate (0, 2 and 4 mg Se L?1) was done. Withholding water at early growth stages significantly increased oxidative stress and decreased growth and grain yield. Irrespective of moisture regimes, foliar application of Se (2 mg L?1) decreased oxidative stress, modulated photosynthetic pigments and fertility and increased grain yield in wheat. The Se-mediated increase in grain yield was attributed to the increase in chlorophyll and ascorbic acid contents and fertility coupled with decrease of oxidative stress under different moisture regimes. The results could be helpful to manage wheat production in the semi-arid environments. 相似文献
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Plasmonics - A highly sensitive absorption-based sensor based on folded split-ring metamaterial graphene resonators (FSRMGRs) is designed, and its biomedical application in terahertz (THz) spectrum... 相似文献
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Sarfraz A. Tunio Neil J. Oldfield Alan Berry Dlawer A. A. Ala'Aldeen Karl G. Wooldridge David P. J. Turner 《Molecular microbiology》2010,76(3):605-615
Fructose‐1, 6‐bisphosphate aldolases (FBA) are cytoplasmic glycolytic enzymes, which despite lacking identifiable secretion signals, have also been found localized to the surface of several bacteria where they bind host molecules and exhibit non‐glycolytic functions. Neisseria meningitidis is an obligate human nasopharyngeal commensal, which has the capacity to cause life‐threatening meningitis and septicemia. Recombinant native N. meningitidis FBA was purified and used in a coupled enzymic assay confirming that it has fructose bisphosphate aldolase activity. Cell fractionation experiments showed that meningococcal FBA is localized both to the cytoplasm and the outer membrane. Flow cytometry demonstrated that outer membrane‐localized FBA was surface‐accessible to FBA‐specific antibodies. Mutational analysis and functional complementation was used to identify additional functions of FBA. An FBA‐deficient mutant was not affected in its ability to grow in vitro, but showed a significant reduction in adhesion to human brain microvascular endothelial and HEp‐2 cells compared to its isogenic parent and its complemented derivative. In summary, FBA is a highly conserved, surface exposed protein that is required for optimal adhesion of meningococci to human cells. 相似文献
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Screening and design of anti-diabetic compounds sourced from the leaves of neem (Azadirachta indica)
Asma Jalil Usman Ali Ashfaq Samar Shahzadi Muhammad Rizwan Javed Ijaz Rasul Shahid-ur Rehman Masaud Shah Muhammad Shareef Masoud 《Bioinformation》2013,9(20):1031-1035
Diabetes Mellitus is affecting people of all age groups worldwide. Many synthetic medicines
available for type 2 diabetes mellitus in the market. However, there is a strong requirement for the
development of better anti-diabetes compounds sourced especially from natural sources like medicinal plants.
The extracts from the leaves of neem (Azadirachta indica) is traditionally known to have anti-diabetes
properties. Therefore, there is an increased interest to identify potential compounds identified from neem leaf
extracts showing predicted binding property with the known diabetes mellitus type 2 protein enzyme target
phosphoenol-pyruvate carboxykinase(PEPCK). The structure data for compounds found in the leaf extract of neem was
screened against PEPCK using molecular docking simulation and screening techniques. Results show that the compound
3-Deacetyl-3-cinnamoyl-azadirachtin possesses best binding properties with PEPCK. This observation finds application
for further consideration in in vitro and in vivo validation. 相似文献
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