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1.
Thomas P Freeman John A Goolsby Sebahat K Ozman Dennis R Nelson 《Australian Journal of Entomology》2005,44(1):57-61
Abstract The ultrastructure of the mite Floracarus perrepae was investigated in relation to its host, Lygodium microphyllum , the Old World climbing fern. Floracarus perrepae has been suggested as a means of biological control for the fern, which is an aggressive weed in tropical areas. Feeding by the mite induces a change in the size of epidermal cells, and cell division is stimulated by mite feeding, causing the leaf margin to curl over into a roll with two to three windings. The enlarged epidermal layer greatly increases its cytoplasmic contents, which become a nutritive tissue for the mite and its progeny. Damage by the mite ultimately debilitates the fern. The structure and depth of stylet penetration by the mite, and the thickness of the epidermal cell wall of L. microphyllum , do not appear to account for the mite's differential ability to induce leaf rolling in its co-adapted host from south-east Queensland but not in the invasive genotype of the fern in Florida. 相似文献
2.
Life History of Kampimodromus aberrans as a predator of Phytoptus avellanae (Acari: Phytoseiidae, Phytoptidae) 总被引:2,自引:0,他引:2
Ozman-Sullivan SK 《Experimental & applied acarology》2006,38(1):15-23
The biology of Kampimodromus aberrans (Oudemans), a predator of the big bud mite, Phytoptus avellanae Nalepa, was studied under laboratory conditions. All experiments were conducted on hazelnut leaf discs in an incubator at
25 ± 1 °C, with 16:8 h L:D, at an average daily relative air humidity of 76%. Observations were made twice daily for the immature
stages and daily for the adults to determine developmental time, survival and fecundity. The mean developmental time for females
was 6.90 days and for males was 7.10 days, and mean adult longevity for females was 11.67 days. The mean total and daily egg
production were 12.67 and 1.85 eggs, respectively. The net reproduction rate (R0) was 7.09 females/female, intrinsic rate of increase (rm) was 0.153 female/female/day and mean generation time (T0) was 12.80 days. The mortality rate of immature stages was 0.66% and the sex ratio was 0.51 female. 相似文献
3.
Orexins have been implicated in the regulation of sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100pmol) and B (100pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity. 相似文献
4.
Insulin-like growth factor I (Igf-1) gene polymorphism in patients with non-metastatic breast cancer
We aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p=0.04), with low histological grade (p=0.04), with positive hormone receptor status (p=0.01), and in patients without recurrence (p=0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival. 相似文献
5.
Turgut G Baştemir M Turgut S Akin F Kursunluoglu R Kaptanoğlu B 《Molecular biology reports》2008,35(4):693-698
P-glycoprotein (Pgp) is encoded by the multidrug resistance gene (MDR1) in humans and is the product of MDR1. It is expressed
in various tissues and is related to drug distribution in intestinal erythrocytes, capillary endotel of brain, proximal tubules
cells of kidneys and liver canalicular cells. Expression of Pgp is affected by Pgp polymorphism, and exon 26 C3435T polymorphism
is the most common one. It has been thought that expression of Pgp is high in C-allele subjects and this situation is responsible
for the resistance against some drugs and substances. Pgp may have a role in the distribution of thyroid hormones, drugs used
for hypo- and hyperthyroidism and the resistance occurred. For this purpose possible relationship between T and C alleles
and frequency of Pgp polymorphism as well as thyroid hormone distribution in patients with hypo- and hyperthyroidism was investigated.
Thirty five hyperthyroidism patients diagnosed as Graves’ disease, 78 hypothyroidism patients diagnosed as Hashimoto’s thyroiditis
and 100 healthy volunteers were included in the study. According to the results obtained no statistically significant difference
was found in Pgp C3435T polymorphism between hypo- and hyperthyroidism patients. In addition, the serum free T3 levels of
hyperthyroidism patients with C alleles was higher than those of subjects with T alleles. No statistically significant difference
was seen in the CC, CT and TT genotype frequencies between the patients and control groups. In conclusion, it seems that Pgp
polymorphism is not a predictor factor for the occurrence of hypo- and hyperthyroidism. There is a significant relationship
between Pgp and the elevated serum free T3 levels of hyperthyroidism patients, and further research will help understand this
situation. 相似文献
6.
Zeynep Nagehan Yuruk Yildirim Sebahat Usta Akgul Harika Alpay Bagdagul Aksu Fatma Savran Oguz Aysel Kiyak Nurver Akinci Sevgi Yavuz Gul Ozcelik Asuman Gedikbasi Ibrahim Gokce Nese Ozkayin Nurdan Yildiz Cemile Pehlivanoglu Nilufer Goknar Seha Saygili Sebahat Tulpar Nuran Kucuk Ilmay Bilge Mehmet Tasdemir Ayse Agbas Ahmet Dirican Sevinc Emre Ahmet Nayir Alev Yilmaz 《Cell stress & chaperones》2021,26(6):973
Various molecular and cellular processes are involved in renal fibrosis, such as oxidative stress, inflammation, endothelial cell injury, and apoptosis. Heat shock proteins (HSPs) are implicated in the progression of chronic kidney disease (CKD). Our aim was to evaluate changes in urine and serum HSP levels over time and their relationships with the clinical parameters of CKD in children. In total, 117 children with CKD and 56 healthy children were examined. The CKD group was followed up prospectively for 24 months. Serum and urine HSP27, HSP40, HSP47, HSP60, HSP70, HSP72, and HSP90 levels and serum anti-HSP60 and anti-HSP70 levels were measured by ELISA at baseline, 12 months, and 24 months. The urine levels of all HSPs and the serum levels of HSP40, HSP47, HSP60, HSP70, anti-HSP60, and anti-HSP70 were higher at baseline in the CKD group than in the control group. Over the months, serum HSP47 and HSP60 levels steadily decreased, whereas HSP90 and anti-HSP60 levels steadily increased. Urine HSP levels were elevated in children with CKD; however, with the exception of HSP90, they decreased over time. In conclusion, our study demonstrates that CKD progression is a complicated process that involves HSPs, but they do not predict CKD progression. The protective role of HSPs against CKD may weaken over time, and HSP90 may have a detrimental effect on the disease course.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12192-021-01239-9. 相似文献
7.
Sebahat Turgut Fulya Akın Raziye Akcılar Ceylan Ayada Günfer Turgut 《Molecular biology reports》2011,38(1):569-576
Acromegaly is associated with increased morbidity and mortality related to cardiovascular disease. Hypertension is one of
the most common cardiovascular risk factors in acromegalic patients. The aim of this study was to investigate association
between the frequencies of angiotensin converting enzyme (ACE) I/D, angiotensinogen (AGT) M235T and the angiotensin II type
1 receptor (AT1-R) A/C1166 gene polymorphisms and some clinical parameters of acromegalic patients. Total of 33 acromegalic
patients and 63 controls were enrolled to study. We determined the ACE I/D, AGT M235T and AT1-R A/C1166 gene polymorphisms.
Serum insulin, glucose, triglyceride, HDL-cholesterol, LDL-cholesterol, growth hormone and Insulin-like growth factor I (IGF-I)
levels of subjects were analyzed. The frequencies of ACE and M235T AGT genotype were not significantly different between control
and patients. The distribution of AT1R A/C1166 genotypes was significantly different between patients and control subjects
(P = 0.016). None of the three ACE genotypes, DD, ID and II displayed significant difference in acromegalic patients. A significant
difference in systolic blood pressure and the serum IGF-I levels among the three AGT genotype, MM, MT and TT genotypes was
found in patient group. Individuals with MT genotypes had significantly higher serum IGF-I levels and systolic blood pressure
than MM and TT genotype subjects, P < 0.05. In addition, serum triglyceride and HDL levels differed significantly between MM and MT genotypes, P < 0.05. However, systolic blood pressure of patients with CC genotypes was found to be significantly higher than AA genotypes
individuals in acromegaly group, P < 0.05. It can be said that the angiotensinojen MT and AT1R CC1166 genotype carriers may have more risk than other genotypes
in the development of hypertension in acromegaly. 相似文献
8.
Yilmaz N Karaali K Ozdem S Turkay M Unal A Dora B 《Cellular and molecular neurobiology》2011,31(4):579-585
Although migraine has mainly been considered as a benign disease, there is cumulative evidence of silent changes in the brain,
brainstem, or cerebellum and subtle subclinical cerebellar dysfunction. In this study, in order to investigate a possible
neuronal and/or glial damage at the cellular level in migraine, we measured and compared serum levels of S100B which is a
protein marker of glial damage or activation, and neuron specific enolase (NSE) which is a marker of neuronal damage, in migraine
patients and control subjects. Serum levels of S100B and NSE were measured in blood samples from 41 patients with migraine-without
aura taken during a migraine attack (ictal) and in the attack-free period between migraine attacks (interictal) and 35 age-
and sex-matched controls. Patients with migraine-without aura had significantly higher ictal serum levels of S100B and NSE
(P < 0.05, for both) than control subjects; whereas in the interictal phase, there was a significant increment only in S100B
levels (P < 0.05) compared to controls. On the other hand, serum levels of S100B and NSE in ictal and interictal blood samples did
not differ significantly. The findings of increased ictal serum S100B and NSE levels together with increased interictal levels
of S100B suggested that migraine might be associated with glial and/or neuronal damage in the brain and a prolonged disruption
of blood–brain barrier. Increased interictal serum levels of S100B might point out to an insidious and slow damaging process
in migraine patients. 相似文献
9.
Kucukatay V Turgut S Kocamaz E Emmungil G Bor-Kucukatay M Turgut G Akca H Bagci H 《Biological trace element research》2006,114(1-3):185-195
Sulfite is a potentially toxic molecule that might enter the body via ingestion, inhalation, or injection. For cellular detoxification,
mammalians rely on sulfite oxidase to convert sulfite to sulfate. The purpose of this research was to determine the effect
of sulfite on zinc, iron, and copper levels in rat liver and kidney tissues. Forty normal and sulfite oxidase-deficient male
albino rats were divided into four groups that included untreated controls (group C), a sulfite-supplemented group that received
70 mg sodium metabisulfite per kilogram per day (group S), a sulfite oxidase-deficient group (group D), and a sulfite oxidase-deficient
group that was also given 70 mg sodium metabisulfite per kilogram per day (group DS). The iron and zinc levels in the liver
and kidney in groups S and DS were not affected by sulfite treatment compared to their respective controls (groups C and D).
Sulfite exposure led to an increase of kidney copper content in the S group when compared to untreated controls. The kidney
copper levels were significantly increased in the unexposed deficient rats, but it was not different than that of the deficient
rats that were given oral sulfite treatment. These results suggest that kidney copper levels might be affected by exogenous
or endogenous sulfite.
An erratum to this article is available at . 相似文献
10.
Sibel Yel İsmail Dursun Feyza Çetin Funda Baştuğ Sebahat Tülpar Ruhan Düşünsel 《Biomarkers》2018,23(6):558-562
Objective: Endothelial microparticles (EMPs) are considered as markers of endothelial dysfunction. In this study, we aimed to examine whether there is endothelial dysfunction in children with familial Mediterranean fever (FMF), hypothesizing that endothelial dysfunction would be present especially with acute-phase response in the active period of the disease.Methods: This cross-sectional study included 65 FMF patients (41 attack free, 24 attack period) and 35 healthy controls. Circulating EMPs, serum amyloid A (SAA), and other inflammation markers were measured in all groups. Circulating EMPs were measured using flow cytometry. Study groups were compared for circulating EMP and inflammatory markers. The relationship between EMPs and the activation of the disease was evaluated.Results: The levels of CD144+ and CD146+ EMPs in the FMF attack period group were significantly higher than those of the control group (p?0.05). The levels of inflammation markers in the attack period group were significantly higher than those of the control and attack-free groups (p?0.05). In the FMF attack group, the CD144+ and CD146+ EMP were significantly correlated with CRP.Conclusions: Our results suggest that endothelial damage is present especially in the active period of the disease in children with FMF. The endothelial dysfunction becomes an overt parallel with inflammation. 相似文献