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A. L. Schwartsman S. V. Sarantseva Yu. A. Tatishcheva O. L. Runova E. I. Talalaeva M. P. Vitek 《Biophysics》2006,51(5):740-743
Most cases of early-onset familial Alzheimer’s disease are caused by mutations in the presenilin 1 gene. Nonetheless, the function of presenilin 1 are not yet completely understood. It was shown that endogenous presenilin 1, as well as the adhesion protein CD44, is concentrated on the surface of lamellipodia of polarized T cells (Jurkat cells) after adhesion to a collagen matrix. This phenomenon was not observed for another surface protein of T cells, T cell receptor, which is not involved in cell adhesion processes. In cultures of primary mouse cortical neurons, presenilin 1 was concentrated on the surface of the growth cone and at neurite contact sites. The concentration of presenilin 1 on the surface of structures that determine cell motility and intercellular contacts suggests that presenilin 1 plays an important role in cell adhesion in motile polarized cells. 相似文献
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Kulabukhova D. G. Garaeva L. A. Emelyanov A. K. Senkevich K. A. Gracheva E. V. Miliukhina I. V. Varfolomeeva E. Y. Timofeeva A. A. Schwartsman A. L. Shtam T. A. Pchelina S. N. 《Molecular Biology》2021,55(2):297-303
Molecular Biology - Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Alpha-synuclein misfolding and aggregation resulting in neurototoxicity is a hallmark of PD.... 相似文献
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