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Walter S Kostpopoulos P Haass A Helwig S Keller I Licina T Schlechtriemen T Roth C Papanagiotou P Zimmer A Viera J Vierra J Körner H Schmidt K Romann MS Alexandrou M Yilmaz U Grunwald I Kubulus D Lesmeister M Ziegeler S Pattar A Golinski M Liu Y Volk T Bertsch T Reith W Fassbender K 《PloS one》2010,5(10):e13758
Background
Early treatment with rt-PA is critical for favorable outcome of acute stroke. However, only a very small proportion of stroke patients receive this treatment, as most arrive at hospital too late to be eligible for rt-PA therapy.Methods and Findings
We developed a “Mobile Stroke Unit”, consisting of an ambulance equipped with computed tomography, a point-of-care laboratory system for complete stroke laboratory work-up, and telemedicine capabilities for contact with hospital experts, to achieve delivery of etiology-specific and guideline-adherent stroke treatment at the site of the emergency, well before arrival at the hospital. In a departure from current practice, stroke patients could be differentially treated according to their ischemic or hemorrhagic etiology even in the prehospital phase of stroke management. Immediate diagnosis of cerebral ischemia and exclusion of thrombolysis contraindications enabled us to perform prehospital rt-PA thrombolysis as bridging to later intra-arterial recanalization in one patient. In a complementary patient with cerebral hemorrhage, prehospital diagnosis allowed immediate initiation of hemorrhage-specific blood pressure management and telemedicine consultation regarding surgery. Call-to-therapy-decision times were 35 minutes.Conclusion
This preliminary study proves the feasibility of guideline-adherent, etiology-specific and causal treatment of acute stroke directly at the emergency site. 相似文献2.
Lehmann Gerlind U. C. Bakanov Nikita Behnisch Martin Bourlat Sarah J. Brühl Carsten A. Eichler Lisa Fickel Thomas Geiger Matthias F. Gemeinholzer Birgit Hörren Thomas Köthe Sebastian Lux Alexandra Meinel Gotthard Mühlethaler Roland Poglitsch Hanna Schäffler Livia Schlechtriemen Ulrich Schneider Florian D. Schulte Ralf Sorg Martin Sprenger Maximilian Swenson Stephanie J. Terlau Wiltrud Turck Angela Zizka Vera M. A. 《Biodiversity and Conservation》2021,30(8-9):2605-2614
Biodiversity and Conservation - Insect declines and biodiversity loss have attracted much attention in recent years, but lack of comprehensive data, conflicting interests among stakeholders and... 相似文献
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