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Mahbobeh Satari Esmat Aghadavod Naghmeh Mirhosseini Zatollah Asemi 《Journal of cellular biochemistry》2019,120(6):9514-9521
Diabetic retinopathy (DR) is one of the major complications of diabetes mellitus that causes diabetic macular edema and visual loss. DR is categorized, based on the presence of vascular lesions and neovascularization, into non-proliferative and proliferative DR. Vascular changes in DR correlate with the cellular damage and pathological changes in the capillaries of blood-retinal barrier. Several cytokines have been involved in inducing neovascularization. These cytokines activate different signaling pathways which are mainly responsible for the complications of DR. Recently; microRNAs (miRNAs) have been introduced as the key factors in the regulation of the cytokine expression which plays a critical role in neovascularization of retinal cells. Some studies have demonstrated that changing levels of miRNAs have essential role in the pathophysiology of vascular changes in patients with DR. The aim of this study is to identify the effects of miRNAs in the pathogenesis of DR via activating neovascularization pathways. 相似文献
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In this paper we investigate the influence of endogeneous AC fields, generated by a living cell itself, on DNA dynamics. Both quantum nonlinear vibron-phonon interaction model and a model of a highly localized excitation are used. The transition of a broad solitonic excitation into a highly localized one affected by AC fields is calculated using Kubo's formalism for linear response of the system. 相似文献
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M. V. Satarić D. I. Ilić N. Ralević Jack Adam Tuszynski 《European biophysics journal : EBJ》2009,38(5):637-647
Microtubules (MTs) are important cytoskeletal polymers engaged in a number of specific cellular activities including the traffic
of organelles using motor proteins, cellular architecture and motility, cell division and a possible participation in information
processing within neuronal functioning. How MTs operate and process electrical information is still largely unknown. In this
paper we investigate the conditions enabling MTs to act as electrical transmission lines for ion flows along their lengths.
We introduce a model in which each tubulin dimer is viewed as an electric element with a capacitive, inductive and resistive
characteristics arising due to polyelectrolyte nature of MTs. Based on Kirchhoff’s laws taken in the continuum limit, a nonlinear
partial differential equation is derived and analyzed. We demonstrate that it can be used to describe the electrostatic potential
coupled to the propagating localized ionic waves.
An erratum to this article can be found at 相似文献
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Applied Microbiology and Biotechnology - Mucoralean fungi are suitable microorganisms for the sustainable production of food, fodder, and fuels from inexpensive natural resources. Ethanol-producing... 相似文献
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Phosphoglucomutase (EC 2.7.5.1, PGM) was purified to homogeneity from maize (Zea mays L.) leaves. The enzyme had specific activity 11. 7 U/mg protein and molecular mass (determined by gel-chromatography) of 133 +/- 4 kD. The molecular mass of PGM subunits determined by SDS-electrophoresis was 66 +/- 3 kD. The enzyme had Km for glucose-1-phosphate and glucose-1,6-diphosphate of 20.0 +/- 0.9 and 16.0 +/- 0.8 &mgr;M, respectively. Concentrations of glucose-1-phosphate and glucose-1,6-diphosphate above 3 and 0.4 mM, respectively, cause substrate inhibition. The enzyme activity was maximal at pH 8.0 and temperature 35 degreesC. Magnesium ions activate the enzyme and manganese ions inhibit it. 3-Phosphoglycerate is an uncompetitive inhibitor of the enzyme (Ki = 1.22 +/- 0.05 mM). Fructose-6-phosphate, 6-phosphogluconate, and ADP activate PGM, whereas ATP, UTP, and AMP inhibit the enzyme. Citrate was also a potent inhibitor, inhibitory effects of isocitrate and cis-aconitate being less pronounced. 相似文献
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Mia TN Godiksen Sara Granstrøm Jørgen Koch Michael Christiansen 《Acta veterinaria Scandinavica》2011,53(1):7
Background
In Maine Coon (MC) cats the c.91G > C mutation in the gene MYBPC3, coding for cardiac myosin binding protein C (cMyBP-C), is associated with feline hypertrophic cardiomyopathy (fHCM). The mutation causes a substitution of an alanine for a proline at residue 31 (p.A31P) of cMyBP-C. The pattern of inheritance has been considered autosomal dominant based on a single pedigree. However, larger studies are needed to establish the significance of cats being heterozygous or homozygous for the mutation with respect to echocardiographic indices and the probability of developing fHCM. The objective of the present study was to establish the clinical significance of being homozygous or heterozygous for the p.A31P cMyBP-C mutation in young to middle-aged cats. 相似文献9.
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A survey of different types of cereal straw samples viz. paddy, maize and wheat, from Bihar State, India, was conducted in
order to examine the mould flora and mycotoxin contamination. Out of 170 samples examined for mould flora,Aspergillus flavus group of fungi had highest level of incidence followed byA niger. Isolates ofA flavus, A ochraceus, Fusarium verticillioides andPenicillium citrinum were screened for their mycotoxins producing abilities. Out of 75, 63 and 68 isolates ofA flavus group obtained from stored straw of paddy, maize and wheat samples, respectively, 27 (36%), 14 (22%) and 24 (35%) were found
to be toxigenic which produced different combinations of aflatoxins in different concentrations. The percentage toxigenicity
was comparatively lower in the isolates of other mycotoxigenic fungi from all types of samples. Out of 222 samples of straw
analysed for natural occurrence of different mycotoxins, besides the aflatoxins present, zearalenone, ochratoxin A and citrinin
were also recorded alone or as co-contaminants. A conducive climate together with the socioeconomic conditions of this region
are important determinants for the high incidence of mycotoxins in cereal straw samples. 相似文献