全文获取类型
收费全文 | 1268篇 |
免费 | 107篇 |
国内免费 | 1篇 |
专业分类
1376篇 |
出版年
2023年 | 7篇 |
2022年 | 24篇 |
2021年 | 35篇 |
2020年 | 16篇 |
2019年 | 22篇 |
2018年 | 26篇 |
2017年 | 24篇 |
2016年 | 29篇 |
2015年 | 44篇 |
2014年 | 53篇 |
2013年 | 68篇 |
2012年 | 92篇 |
2011年 | 95篇 |
2010年 | 43篇 |
2009年 | 42篇 |
2008年 | 69篇 |
2007年 | 69篇 |
2006年 | 57篇 |
2005年 | 55篇 |
2004年 | 56篇 |
2003年 | 57篇 |
2002年 | 35篇 |
2001年 | 26篇 |
2000年 | 18篇 |
1999年 | 22篇 |
1998年 | 13篇 |
1997年 | 11篇 |
1996年 | 15篇 |
1995年 | 15篇 |
1994年 | 14篇 |
1993年 | 6篇 |
1992年 | 10篇 |
1991年 | 22篇 |
1990年 | 11篇 |
1989年 | 9篇 |
1988年 | 11篇 |
1987年 | 9篇 |
1986年 | 10篇 |
1983年 | 7篇 |
1982年 | 7篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1976年 | 8篇 |
1975年 | 6篇 |
1974年 | 7篇 |
1973年 | 8篇 |
1971年 | 6篇 |
1970年 | 11篇 |
1969年 | 6篇 |
1968年 | 10篇 |
排序方式: 共有1376条查询结果,搜索用时 15 毫秒
1.
2.
3.
Krishnan V 《Social biology》1991,388(3-4):249-257
This paper examines a number of demographic and sociocultural factors (e.g., age, marital status, family size, religion, religious assiduity, sex-role ideology) as predictors of women's attitudes toward abortion, using data from the Canadian Fertility Survey of 1984. The findings suggest that women's abortion attitudes are to a greater extent based on ideological positions. It appears that anti-abortion stance affects those women who are religious, presumably by increasing the relationship between their general sex-role ideological stances and abortion attitudes. Abortion attitudes also vary according to a woman's education, her size, and province/region of residence. 相似文献
4.
5.
6.
V Krishnan 《Social biology》1990,37(1-2):59-68
This paper tests, within the framework of LISREL, the causal structures of fertility using data from the 1973-74 Growth of Alberta Family Study (GAFS) of women aged 18-44 who are currently married or living common-law. Differential fertility among two groups of women classified by nativity also are examined. The women's background characteristics (e.g., age, religiosity, and education) are viewed as exogenous variables. The endogenous variables are familism and expected family size; familism is designated as an intermediate variable in the model, linking demographic and socioeconomic (including cultural) factors to fertility, The results indicate that familism acts as an important variable explaining fertility, particularly, among foreign-born women. The study confirms and extends earlier research findings that religiosity and education influence couples' fertility, the former positively and the latter negatively. 相似文献
7.
Krishnan S. S. McNeill K. G. Mernagh J. R. Harrison J. E. 《Biological trace element research》1990,(1):415-421
Two new facilities for in vivo activation analysis of patients have been designed, developed, and constructed at Toronto General
Hospital. One of these is for the determination of body calcium for the diagnosis of osteoporosis and other diseases associated
with bone loss. The other is for the measurement of total body nitrogen for the determination of protein status.
These facilities replace old university facilities and take into account the comfort and management of patients. In addition,
in the case of the calcium facility, the precision of the measurements has been improved because of larger detector volume
and increased neutron source strength. Both the facilities are now in routine hospital clinical use. 相似文献
8.
9.
Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1'' binding site. 下载免费PDF全文
J H Matthews R Krishnan M J Costanzo B E Maryanoff A Tulinsky 《Biophysical journal》1996,71(5):2830-2839
Structures of the blood clotting enzyme thrombin complexed with hirugen and two active site inhibitors, RWJ-50353 10080(N-methyl-D-phenylalanyl-N-[5-[(aminoiminomethyl)amino]-1- [[(2-benzothiazolyl)carbonyl]butyl]-L-prolinamide trifluoroacetate hydrate) and RWJ-50215 (N-[4-(aminoiminomethyl)amino-1-[2- (thiazol-2-ylcarbonylethyl)piperidin- 1-ylcarbonyl]butyl]-5-(dimethylamino)naphthalenesulfonamide trifluoroacetate hydrate), were determined by x-ray crystallography. The refinements converged at R values of 0.158 in the 7.0-2.3-A range for RWJ-50353 and 0.155 in the 7.0-1.8-A range for RWJ-50215. Interactions between the protein and the thiazole rings of the two inhibitors provide new valuable information about the S1' binding site of thrombin. The RWJ-50353 inhibitor consists of an S1'-binding benzothiazole group linked to the D-Phe-Pro-Arg chloromethyl ketone motif. Interactions with the S1-S3 sites are similar to the D-phenylalanyl-prolyl-arginyl chloromethylketone structure. In RWJ-50215, a S1'-binding 2-ketothiazole group was added to the thrombin inhibitor-like framework of dansylarginine N-(3-ethyl-1,5-pentanediyl)amide. The geometry at the S1-S3 sites here is also similar to that of the parent compound. The benzothiazole and 2-ketothiazole groups bind in a cavity surrounded by His57, Tyr60A, Trp60D, and Lys60F. This location of the S1' binding site is consistent with previous structures of thrombin complexes with hirulog-3, CVS-995, and hirutonin-2 and -6. The ring nitrogen of the RWJ-50353 benzothiazole forms a hydrogen bond with His57, and Lys60F reorients because of close contacts. The oxygen and nitrogen of the ketothiazole of RWJ-50215 hydrogen bond with the NZ atom of Lys60F. 相似文献
10.
The effect of structural changes in the N-terminal amino acid of AIV, with respect to AT4 receptor binding, was examined by competition with [125I]AIV in bovine adrenal membranes. Analogues with modifications of the first residue α-amino group possessed lower affinities than the primary amine-containing parent compound. Peptides with a residue 1 α-carbon in the d conformation exhibited poor affinity for the AT4 receptor. Modifications of the residue 1 R-group demonstrate that a straight chain aliphatic moiety containing four carbons is optimal for receptor-ligand binding, as evidenced by the extremely high affinity of [Nle1]AIV (Ki = 3.59±0.51 pM). Replacement of the 1–2 peptide bond of AIV with the methylene bond isostere Ψ (CH2-NH), increased the Ki approximately fivefold, indicating that the peptide bond may be replaced wihle maintaining relatively high-affinity receptor binding. 相似文献