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Sae-Il Murtada Martin Kroon Gerhard A. Holzapfel 《Biomechanics and modeling in mechanobiology》2010,9(6):749-762
A new model for the mechanochemical response of smooth muscle is presented. The focus is on the res- ponse of the actin–myosin complex and on the related generation of force (or stress). The chemical (kinetic) model describes the cross-bridge interactions with the thin filament in which the calcium-dependent myosin phosphorylation is the only regulatory mechanism. The new mechanical model is based on Hill’s three-component model and it includes one internal state variable that describes the contraction/relaxation of the contractile units. It is characterized by a strain-energy function and an evolution law incorporating only a few material parameters with clear physical meaning. The proposed model satisfies the second law of thermodynamics. The results of the combined coupled model are broadly consistent with isometric and isotonic experiments on smooth muscle tissue. The simulations suggest that the matrix in which the actin–myosin complex is embedded does have a viscous property. It is straightforward for implementation into a finite element program in order to solve more complex boundary-value problems such as the control of short-term changes in lumen diameter of arteries due to mechanochemical signals. 相似文献
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Murtada Sae-Il Kawamura Yuki Cavinato Cristina Wang Molly Ramachandra Abhay B. Spronck Bart Li David S. Tellides George Humphrey Jay D. 《Biomechanics and modeling in mechanobiology》2023,22(4):1333-1347
Biomechanics and Modeling in Mechanobiology - Hutchinson–Gilford Progeria Syndrome results in rapid aging and severe cardiovascular sequelae that accelerate near end-of-life. We found a... 相似文献
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Murtada Sae-Il Latorre Marcos Humphrey Jay D. 《Biomechanics and modeling in mechanobiology》2023,22(5):1531-1540
Biomechanics and Modeling in Mechanobiology - Pregnancy associates with dramatic changes in maternal cardiovascular physiology that ensure that the utero-placental circulation can support the... 相似文献
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