排序方式: 共有1条查询结果,搜索用时 0 毫秒
1
1.
Sheroziya O. P. Ermishkin V. V. Lukoshkova E. V. Mazygula E. P. Ryb'yakova V. B. Chepetova T. V. 《Neurophysiology》2003,35(6):434-444
In 19 tested persons in the resting lying position, we examined changes in the mean duration of R-R intervals
and in parasympathetic chronotropic cardiac reactions (respiratory arrhythmia,RA, and swallowing-related tachycardia, ST) induced by intensified tonic parasympathetic influences after peroral administration of antagonists of muscarinic (M) receptors in small doses. Administration of 0.02 g of an extract of Belladonna, which contains alkaloids of the atropine group, led to a significant
increase (P < 0.001). In this case, the RA at the natural frequency of breathing (P < 0.05) and ST (P < 0.001) simultaneously increased. Close correlation was observed both between initial values of the ST and
in various tested persons (r = 0.87) and between changes in these values, which were induced by the action of small amounts of M antagonists (r = 84). In various persons, the RA during deep slowed breathing (6 min-1, RA6) demonstrated ambiguous modifications. In the structure of RA6, we identified two components: an inspiratory tachycardic (TC) and an expiratory bradycardic (BC). With intensification of the parasympathetic influences, the TC began to prevail; its increase was strongly related to a rise in the
(r = 0.84). In contrast, correlation between changes in the BC and an increase in the
was completely absent (r = 0.001). Therefore, small amounts of M antagonists intensify both the tonic component of parasympathetic control (increasing the
) and its dynamic indices, the magnitudes of the ST and RA. Tachycardia during swallowing and the inspiratory TC under conditions of deep slowed breathing are closely related to changes in the parasympathetic influences. The magnitude of the RA is the index, which reflects the tonic component of chtonotropic control under conditions of both slowed and natural breathing less adequately than the ST. 相似文献
1