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Vasil'ev SA Stepanova EIu Kutenkov OP Belenko AA Zharkova LP Bol'shakov MA Lebedev IN Rostov VV 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2012,52(1):31-38
Effects of ionizing radiation registered in cells after low dose irradiation are still poorly understood. A pulsed mode of irradiation is even more problematic in terms of predicting the radiation-induced response in cells. Thus, the aim of this paper was to study and analyze the effects of dose and frequency of pulsed X-rays on the frequency of radiation-induced DNA double-strand breaks and their repair kinetics in human peripheral blood lymphocytes in vitro. Analysis of radiation-induced gammaH2AX and 53BP1 repair foci was used to assess the DNA damage in these cells. The dose-response curve of radiation-induced foci of both proteins has shown deviations from linearity to a higher effect in the 12-32 mGy dose range and a lower effect at 72 mGy. The dose-response curve was linear at doses higher than 100 mGy. The number of radiation-induced gammaH2AX and 53BP1 foci depended on the frequency of X-ray pulses: the highest effect was registered at 13 pulses per second. Moreover, slower repair kinetics was observed for those foci induced by very low doses with a nonlinear dose-response relationship. 相似文献
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I. L. Bogdankevich D. M. Grishin A. V. Gunin I. E. Ivanov S. D. Korovin O. T. Loza G. A. Mesyats D. A. Pavlov V. V. Rostov P. S. Strelkov D. K. Ul’yanov 《Plasma Physics Reports》2008,34(10):855-859
A repetitively rated microwave oscillator whose frequency can be varied electronically from pulse to pulse in a predetermined manner is created for the first time. The microwave oscillator has a power on the order of 108 W and is based on the Cherenkov interaction of a high-current relativistic electron beam with a plasma preformed before each pulse. Electronic control over the plasma properties allows one to arbitrarily vary the microwave frequency from pulse to pulse at a pulse repetition rate of up to 50 Hz. 相似文献
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Aruna Kasoju M Lakshmi Narasu Charuvaka Muvva Bathula VV SubbaRao 《Bioinformation》2012,8(14):684-686
Aflatoxins are polyketide-derived secondary metabolites produced by Aspergillus spp. The toxic effects of aflatoxins have adverse
consequences for human health and agricultural economics. The aflR gene, a regulatory gene for aflatoxin biosynthesis, encodes a
protein containing a zinc-finger DNA-binding motif. AFLR-Protein three-dimensional model was generated using Robetta server.
The modeled AFLR-Protein was further optimization and validation using Rampage. In the simulations, we monitored the
backbone atoms and the C-α-helix of the modeled protein. The low RMSD and the simulation time indicate that, as expected, the
3D structural model of AFLR-protein represents a stable folding conformation. This study paves the way for generating computer
molecular models for proteins whose crystal structures are not available and which would aid in detailed molecular mechanism of
inhibition of aflatoxin. 相似文献
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Bol'shakov MA Librikht OK Kniazeva IR El'chaninov AA Klimov AI Rostov VV 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2007,47(1):22-27
The effect of 13 Hz repetition rate X-ray pulses with 3 x 10(-6)-1.5 x 10(-4) Gr per pulse dose during 5 minute on drosophila's larvae and on pupae vas investigated. It was shown that the effect depends on drosophila's age as well as on X-ray dose and manifests itself in variation of life expectancy and fertility. 相似文献
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Visualization of molecular structures aids in the understanding of structural and functional roles of biological macromolecules.
Macromolecular transport between the cell nucleus and cytoplasm is facilitated by the nuclear pore complex (NPC). The ring
structure of the NPC is large and contains several distinct proteins (nucleoporins) which function as a selective gate for the passage
of certain molecules into and out of the nucleus. In this note we demonstrate the utility of a python code that allows direct
mapping of the physiochemical properties of the constituent nucleoporins on the scaffold of the yeast NPC׳s cytoplasmic view. We
expect this tool to be useful for researchers to visualize the NPC based on their physiochemical properties and how it alters when
specific mutations are introduced in one or more of the nucleoporins. The code developed using Python is available freely from the
authors. 相似文献
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VV. R. PHILIPSON F.L.S. 《Botanical journal of the Linnean Society. Linnean Society of London》1987,95(1):19-25
Problems presented by genera, or small groups of genera, which have been given family rank are reviewed, and the genera are divided into a number of categories according to the closeness of their affinity to other genera or families. Satellite genera that stand in close relation to families should be united with them. Binary families, that have been divided into two (or more) related families, should be re–united. Families connected by linking genera, should, logically, be united but practical considerations usually prevent this. Clusters of diverse but more or less distantly related genera present unusual problems, being treated either as several, often monogeneric families or as a loosely structured family. Truly isolated genera must be given family and often ordinal rank. 相似文献
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Gostyukhina A. A. Samoylova A. V. Bolshakov M. A. Mochalova V. M. Zaitsev K. V. Kutenkov O. P. Rostov V. V. 《Biology Bulletin》2022,49(5):532-537
Biology Bulletin - The effect of nanosecond repetitive pulsed microwave radiation (RPMR, 10 GHz, 100 ns pulse duration, 8 Hz pulse repetition rate, 140 and 1500 W/cm2 peak power flux density... 相似文献
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