全文获取类型
收费全文 | 496篇 |
免费 | 145篇 |
国内免费 | 1篇 |
专业分类
642篇 |
出版年
2022年 | 6篇 |
2021年 | 5篇 |
2020年 | 4篇 |
2019年 | 5篇 |
2018年 | 7篇 |
2016年 | 4篇 |
2015年 | 15篇 |
2014年 | 13篇 |
2013年 | 23篇 |
2012年 | 19篇 |
2011年 | 23篇 |
2010年 | 20篇 |
2009年 | 26篇 |
2008年 | 15篇 |
2007年 | 11篇 |
2006年 | 29篇 |
2005年 | 17篇 |
2004年 | 24篇 |
2003年 | 24篇 |
2002年 | 21篇 |
2001年 | 14篇 |
2000年 | 33篇 |
1999年 | 18篇 |
1998年 | 17篇 |
1997年 | 7篇 |
1996年 | 8篇 |
1995年 | 6篇 |
1994年 | 15篇 |
1993年 | 6篇 |
1992年 | 17篇 |
1991年 | 24篇 |
1990年 | 15篇 |
1989年 | 21篇 |
1988年 | 21篇 |
1987年 | 18篇 |
1986年 | 6篇 |
1985年 | 11篇 |
1984年 | 11篇 |
1983年 | 10篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1975年 | 6篇 |
1974年 | 7篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1966年 | 4篇 |
排序方式: 共有642条查询结果,搜索用时 8 毫秒
1.
2.
3.
4.
5.
C Haddad M Wilkinson L M Roeder J T Tildon J A Armour 《Canadian journal of physiology and pharmacology》1987,65(9):1928-1933
A new technique was developed to characterize the binding of a hydrophilic beta-adrenergic antagonist, [3H]CGP-12177, to 1-mm thick slices of canine cardiac tissue. This technique was used to quantify the density (Bmax) and the affinity (Kd) of these receptors in the right ventricular conus (RVC) and the left ventricle (LV) at day 1 to 6 weeks of age, and in the adult. Binding was found to be reversible, saturable, stereospecific, of high affinity, and thermolabile. There was an increase in the density of beta-adrenergic receptors between day 1 (Bmax = 2.2 +/- 0.3 fmol/mg tissue in RVC and 2.9 +/- 0.8 fmol/mg tissue in the LV) and 2 weeks of age postnatally, after which it remained constant until 6 weeks of age (Bmax = 7.5 +/- 0.4 and 6.8 +/- 0.9 fmol/mg tissue in RVC and LV, respectively); however, by 6 weeks of age it had not reached adult levels (10.3 +/- 1.0 fmol/mg tissue). The affinity of these receptors did not change between early neonatal life (Kd = 1.3 +/- 0.4 nM) and adulthood (Kd = 1.4 +/- 0.2 nM). The density of beta-adrenergic receptors in the RVC was similar to that in the LV. This new method of quantifying beta-adrenergic receptors in cardiac tissue is simple and fast, and requires minimal tissue handling. It proved to be useful in studying the development of cardiac beta-adrenergic receptors with age. 相似文献
6.
7.
8.
9.
Mechanism of action of a yeast activator: direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions 总被引:62,自引:0,他引:62
We have analyzed interactions between the mammalian TATA factor (TFIID) and derivatives of the yeast activator GAL4. The interaction of the TATA factor on the adenovirus E4 promoter with GAL4 binding sites adjacent to the TATA site was qualitatively altered in response to GAL4 binding. Alterations in the TFIID interactions were observed with two GAL4 derivatives that stimulated hybrid E4 promoter activity in vitro but not with a third derivative that bound to DNA but showed no activation. These results indicate that TFIID is a direct target for a GAL4 activation domain and suggest a simple general model for the activation mechanism. 相似文献