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Yasuyuki Taira Naomi Hayashida Rimi Tsuchiya Hitoshi Yamaguchi Jumpei Takahashi Alexander Kazlovsky Marat Urazalin Tolebay Rakhypbekov Shunichi Yamashita Noboru Takamura 《PloS one》2013,8(2)
For the current on-site evaluation of the environmental contamination and contributory external exposure after the accident at the Chernobyl Nuclear Power Plant (CNPP) and the nuclear tests at the Semipalatinsk Nuclear Testing Site (SNTS), the concentrations of artificial radionuclides in soil samples from each area were analyzed by gamma spectrometry. Four artificial radionuclides (241Am, 134Cs, 137Cs, and 60Co) were detected in surface soil around CNPP, whereas seven artificial radionuclides (241Am, 57Co, 137Cs, 95Zr, 95Nb, 58Co, and 60Co) were detected in surface soil around SNTS. Effective doses around CNPP were over the public dose limit of 1 mSv/y (International Commission on Radiological Protection, 1991). These levels in a contaminated area 12 km from Unit 4 were high, whereas levels in a decontaminated area 12 km from Unit 4 and another contaminated area 15 km from Unit 4 were comparatively low. On the other hand, the effective doses around SNTS were below the public dose limit. These findings suggest that the environmental contamination and effective doses on the ground definitely decrease with decontamination such as removing surface soil, although the effective doses of the sampling points around CNPP in the present study were all over the public dose limit. Thus, the remediation of soil as a countermeasure could be an extremely effective method not only for areas around CNPP and SNTS but also for areas around the Fukushima Dai-ichi Nuclear Power Plant (FNPP), and external exposure levels will be certainly reduced. Long-term follow-up of environmental monitoring around CNPP, SNTS, and FNPP, as well as evaluation of the health effects in the population residing around these areas, could contribute to radiation safety and reduce unnecessary exposure to the public. 相似文献
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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity 总被引:189,自引:0,他引:189
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Jessica M. Faupel-Badger David E. Nelson Grant Izmirlian Katherine H. Ross Kimberley Raue Sophia Tsakraklides Atsushi Miyaoka Maura Spiegelman 《PloS one》2015,10(12)
The purpose of this study was to examine the career paths of alumni from the National Cancer Institute (NCI) Cancer Prevention Fellowship Program (CPFP), a structured in-house postdoctoral training program of 3–4 years duration, and specifically what proportion of the alumni were currently performing cancer prevention-related activities. The analyses here included 119 CPFP alumni and 85 unsuccessful CPFP applicants, all of whom completed postdoctoral training between 1987–2011 and are currently employed. Postdoctoral training experiences and current career outcomes data were collected via online surveys. Differences between groups were assessed using chi-square and Fisher’s exact test p-values and subsequent regression analyses adjusted for differences between the groups. Compared to 15.3% of unsuccessful CPFP applicants, 52.1% of CPFP alumni (odds ratio [OR] = 4.99, 95% confidence interval [95% CI): 1.91–13.0) were currently spending the majority of their time working in cancer prevention. Among those doing any cancer prevention-focused work, 54.3% of CPFP alumni spent the majority of their time performing cancer prevention research activities when compared to 25.5% of unsuccessful applicants (OR = 4.26, 95% CI: 1.38–13.2). In addition to the independent effect of the NCI CPFP, scientific discipline, and employment sector were also associated with currently working in cancer prevention and involvement in cancer prevention research-related activities. These results from a structured postdoctoral training program are relevant not only to the cancer prevention community but also to those interested in evaluating alignment of postdoctoral training programs with available and desired career paths more broadly. 相似文献
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Kataoka M Yamamori S Suzuki E Watanabe S Sato T Miyaoka H Azuma S Ikegami S Kuwahara R Suzuki-Migishima R Nakahara Y Nihonmatsu I Inokuchi K Katoh-Fukui Y Yokoyama M Takahashi M 《PloS one》2011,6(9):e25158
Synaptosomal-associated protein of 25 kDa (SNAP-25) is a presynaptic protein essential for neurotransmitter release. Previously, we demonstrate that protein kinase C (PKC) phosphorylates Ser(187) of SNAP-25, and enhances neurotransmitter release by recruiting secretory vesicles near to the plasma membrane. As PKC is abundant in the brain and SNAP-25 is essential for synaptic transmission, SNAP-25 phosphorylation is likely to play a crucial role in the central nervous system. We therefore generated a mutant mouse, substituting Ser(187) of SNAP-25 with Ala using "knock-in" technology. The most striking effect of the mutation was observed in their behavior. The homozygous mutant mice froze readily in response to environmental change, and showed strong anxiety-related behavior in general activity and light and dark preference tests. In addition, the mutant mice sometimes exhibited spontaneously occurring convulsive seizures. Microdialysis measurements revealed that serotonin and dopamine release were markedly reduced in amygdala. These results clearly indicate that PKC-dependent SNAP-25 phosphorylation plays a critical role in the regulation of emotional behavior as well as the suppression of epileptic seizures, and the lack of enhancement of monoamine release is one of the possible mechanisms underlying these defects. 相似文献
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P. C. S. Kirnev J. C. de Carvalho J. T. Miyaoka L. C. Cartas L. P. S. Vandenberghe C. R. Soccol 《Journal of applied phycology》2018,30(4):2317-2324
Microalgal cultures are inherently dilute, and increasing their concentration is essential for volume reduction and further processing. Flocculation is a classical operation in water treatment that is also used as a concentration step in microalgal biotechnology. However, flocculation is highly dependent on the physicochemical characteristics of the system, such as cell charge and concentration, pH, and solutes in the system, and the coagulant or flocculant to be used. This paper describes the efficiency of nine flocculating agents applied to Neochloris oleoabundans flocculation: low molecular weight chitosan; Zetag® 8165, 8185, 7652, and 4120; Magnafloc® LT22 and 351; and Tanfloc® SG and SH. The influence of flocculant concentration (from 3 to 16 mg L?1) and pH (from 6 to 10) was evaluated, showing a small influence of pH and a large influence of the type and concentration of flocculating agent. These effects are discussed regarding the flocculant charge and the zeta potential of the cells. The best flocculants were Zetag® 8185, Zetag® 8165, and chitosan, with floc sedimentation efficiencies higher than 95%. These flocculants were further evaluated for their efficiency in various concentrations at the native pH of N. oleoabundans cultures, with good efficiency. 相似文献
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Nadia Ali Rimi Rebeca Sultana Kazi Ishtiak-Ahmed Salah Uddin Khan M. A. Yushuf Sharker Rashid Uz Zaman Eduardo Azziz-Baumgartner Emily S. Gurley Nazmun Nahar Stephen P. Luby 《EcoHealth》2014,11(1):83-93
Slaughtering sick poultry is a risk factor for human infection with highly pathogenic avian influenza and is a common practice in Bangladesh. This paper describes human exposures to poultry during slaughtering process and the customs and rituals influencing these practices in two Bangladeshi rural communities. In 2009, we conducted 30 observations to observe slaughtering practices and 110 in-depth and short interviews and 36 group discussions to explore reasons behind those practices. The villagers reported slaughtering 103 poultry, including 20 sick poultry during 2 months. During different stages of slaughtering, humans, the environment, healthy poultry, and other animals were exposed to poultry blood and body parts. Women performed most of the slaughtering tasks, including evisceration. Defeathering required the most time and involved several persons. During festivals, ceremonies, and rituals, many people gathered and participated in the slaughtering of poultry. Exposure to poultry slaughtering created numerous opportunities for potential avian influenza transmission. Strategies that can be further tested to determine if they reduce the risk of transmission include skinning the carcasses of sick poultry, using hot water for defeathering and cleaning, using a bucket to contain slaughtering blood and carcass, burying the offal and encouraging handwashing. 相似文献
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