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Isabel J. Wajda Miriam Banay-Schwartz Isaac Manigault Abel Lajtha 《Neurochemical research》1986,11(7):949-957
In vivo effects of chronic lithium administration on dopaminergic and serotonergic receptor binding were studied in the striatum and cerebral cortex of the rat. [3H]Domperidone was used as the ligand for the dopaminergic receptor, and [3H]ketanserin for the serotonergic system. Long-term ingestion of lithium (2–3 months) resulted in high levels of lithium in the cerebral cortex and significantly higher potassium levels; the sodium content remained at normal levels. The kinetic constants (K
d andB
max) of [3H]domperidone binding sites measured in the striatum did not show any deviation from control values, but the receptor concentration (B
max) of [3H]ketanserin binding sites was significantly reduced in the cerebral cortex of lithium-treated rats. The apparent dissociation constant (K
d) was not changed. The results indicate that the serotonergic component of the [3H]spiperone binding site, which we had previously found to be affected by chronic lithium treatment and which was shown by Peroutka and Snyder (1) to be the 5-HT2 receptor, is selectively affected by lithium.Special Issue dedicated to Prof. Eduardo De Robertis. 相似文献
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The flexibility of bacterial cell walls 总被引:6,自引:0,他引:6
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Intrathecally injected dynorphin A (1-13) in rats results in a reversible hindlimb paralysis and an irreversible loss of the tail-flick reflex. Histologic examination of the spinal cords of dynorphin treated rats demonstrated dead and/or dying neurons predominately localized in the central area which approximates Rexed lamina VII and X. In this area a maximum effect of the dynorphin-induced neurotoxicity is evident. Thus, the dynorphin-induced neuron death is suggestive of an anatomical selectivity. 相似文献
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We examine the performance of Hebbian-like attractor neural networks, recalling stored memory patterns from their distorted
versions. Searching for an activation (firing-rate) function that maximizes the performance in sparsely connected low-activity
networks, we show that the optimal activation function is a threshold-sigmoid of the neuron's input field. This function is shown to be in close correspondence with the dependence of the firing rate
of cortical neurons on their integrated input current, as described by neurophysiological recordings and conduction-based
models. It also accounts for the decreasing-density shape of firing rates that has been reported in the literature.
Received:9 December 1994 / Accepted in revised form: 9 January 1996 相似文献
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Boris Blumenstein Isaac Breslav Michael Bar-Eli Gershon Tenenbaum Yitzhak Weinstein 《Applied psychophysiology and biofeedback》1995,20(2):169-183
The purpose of the present study was to examine whether breathing pattern may be used as a reliable index for the effectiveness of techniques applied for the regulation of mental states. Heart rate (HR), breathing pattern, galvanic skin response (GSR), and electromyogram (EMG) of the frontalis muscle were measured in 39 male and female subjects aged 18–25 years during 10-minute treatment with relaxation technique (autogenic training and/or music) followed by 10 minutes of imagery training. In the first 7 sessions biofeedback (BFB) was not included, while during the last 6 sessions BFB was introduced and utilized by the subjects. Relaxation (music or autogenic training) led to a decrease in breathing frequency, attributed to lengthening of expiration time, as well as reduced HR, GSR, and frontalis EMG response. In most instances imagery training was related to an increase in these indices. Specifically, significant tachypnea was observed during imagery of sprint running. In most cases BFB substantially augmented the physiological responses. In conclusion, our data suggest that, compared with HR, GSR, and EMG responses, the breathing pattern is at least as sensitive to the mental techniques employed, and may be useful as a psychophysiological index for diagnosis and testing, especially in sport practice. 相似文献
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Linden Ellie Rittenhouse Chadwick D. Peel Michael J. S. Ortega Isaac M. Smit Izak P. J. 《Ecosystems》2023,26(4):768-783
Ecosystems - In the early 1990’s, reserves adjacent to Kruger National Park (KNP) removed their fences to create a continuous landscape within the Kruger to Canyons Biosphere Reserve.... 相似文献