排序方式: 共有35条查询结果,搜索用时 187 毫秒
1.
Ana O. Fagundes Maira R. Aguiar Claudia S. Aguiar Giselli Scaini Monique U. Sachet Nayara M. Bernhardt Gislaine T. Rezin Samira S. Valvassori João Quevedo Emilio L. Streck 《Neurochemical research》2010,35(11):1675-1680
Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works
regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of
chronic administration of methylphenidate on the activities of mitochondrial respiratory chain complexes I and III in the
brain of young rats. The effect of acute administration of methylphenidate on mitochondrial respiratory chain complexes I,
II, III and IV in the brain of young rats was also investigated. For acute administration, a single injection of methylphenidate
was given to rats on postnatal day 25. For chronic administration, methylphenidate injections were given starting at postnatal
day 25 once daily for 28 days. Our results showed that complexes I and III were not affected by chronic administration of
methylphenidate. Moreover, the acute administration of methylphenidate decreased complex I activity in cerebellum and prefrontal
cortex, whereas complexes II, III and IV were not altered. 相似文献
2.
de Farias Bianca Xavier Costa Ana Beatriz Engel Nicole Alessandra de Souza Goldim Mariana Pereira da Rosa Turatti Cristini Cargnin-Cavalho Anderson Fortunato Jucélia Jeremias Petronilho Fabricia Jeremias Isabela Casagrande Rezin Gislaine Tezza 《Neurochemical research》2020,45(10):2487-2498
Neurochemical Research - Obesity is characterized by chronic inflammation of low grade. The cholinergic anti-inflammatory pathway favors the reduction of the inflammatory response. In this work the... 相似文献
3.
Piccinini Alexandre Oliveira Mariana Pacheco Silva Mariella Reinol Bett Gabriela Souza Becker Isabel Borges Mendes Talita Farias Salla Daniéle Hendler Silva Larissa Espindola Vilela Thais Ceresér Moraes Fernanda Mendes Moterle Diego Damiani Adriani Paganini Dagostin Lígia Salvan Tietbohl Lariani Tamires Bittencourt João Vitor Silvano Biehl Erica Denicol Tais Luise Bonfante Sandra Regina Andrade Vanessa Moraes Silveira Paulo Cesar Lock Prophiro Josiane Somariva Ferreira Gabriela Kozuchovski Petronilho Fabricia Kanis Luiz Alberto Rezin Gislaine Tezza 《Neurochemical research》2022,47(7):1888-1903
Neurochemical Research - This study aimed to evaluate the effect of Cynara cardunculus leaf ethanol extract on inflammatory and oxidative stress parameters in the hypothalamus, prefrontal cortex,... 相似文献
4.
JG Hansen W Gao J Dupuis GT O’Connor W Tang M Kowgier A Sood SA Gharib LJ Palmer M Fornage SR Heckbert BM Psaty SL Booth SUNLIGHT Consortium Patricia A Cassano 《Respiratory research》2015,16(1)
Background
Vitamin D is associated with lung function in cross-sectional studies, and vitamin D inadequacy is hypothesized to play a role in the pathogenesis of chronic obstructive pulmonary disease. Further data are needed to clarify the relation between vitamin D status, genetic variation in vitamin D metabolic genes, and cross-sectional and longitudinal changes in lung function in healthy adults.Methods
We estimated the association between serum 25-hydroxyvitamin D [25(OH)D] and cross-sectional forced expiratory volume in the first second (FEV1) in Framingham Heart Study (FHS) Offspring and Third Generation participants and the association between serum 25(OH)D and longitudinal change in FEV1 in Third Generation participants using linear mixed-effects models. Using a gene-based approach, we investigated the association between 241 SNPs in 6 select vitamin D metabolic genes in relation to longitudinal change in FEV1 in Offspring participants and pursued replication of these findings in a meta-analyzed set of 4 independent cohorts.Results
We found a positive cross-sectional association between 25(OH)D and FEV1 in FHS Offspring and Third Generation participants (P = 0.004). There was little or no association between 25(OH)D and longitudinal change in FEV1 in Third Generation participants (P = 0.97). In Offspring participants, the CYP2R1 gene, hypothesized to influence usual serum 25(OH)D status, was associated with longitudinal change in FEV1 (gene-based P < 0.05). The most significantly associated SNP from CYP2R1 had a consistent direction of association with FEV1 in the meta-analyzed set of replication cohorts, but the association did not reach statistical significance thresholds (P = 0.09).Conclusions
Serum 25(OH)D status was associated with cross-sectional FEV1, but not longitudinal change in FEV1. The inconsistent associations may be driven by differences in the groups studied. CYP2R1 demonstrated a gene-based association with longitudinal change in FEV1 and is a promising candidate gene for further studies.Electronic supplementary material
The online version of this article (doi:10.1186/s12931-015-0238-y) contains supplementary material, which is available to authorized users. 相似文献5.
Ana O. Fagundes Giselli Scaini Patricia M. Santos Monique U. Sachet Nayara M. Bernhardt Gislaine T. Rezin Samira S. Valvassori Patrícia F. Schuck João Quevedo Emilio L. Streck 《Neurochemical research》2010,35(3):405-411
Methylphenidate (MPH) is frequently prescribed for the treatment of attention deficit/hyperactivity disorder. It was previously
demonstrated that MPH altered brain metabolic activity. Most cell energy is obtained through oxidative phosphorylation, in
the mitochondrial respiratory chain. However, there are still few studies about MPH effects on the brain of adult rats. Thus,
in the present study we evaluated the effect of acute or chronic administration of MPH on the activities of mitochondrial
respiratory chain complexes I–IV in the brain of adult rats. For acute administration, a single injection of MPH was given
to 60-day-old rats. For chronic administration, MPH injections were given to 60-day-old rats once daily for 28 days. Our results
showed that complexes I, II, III and IV were inhibited after acute or chronic MPH administration in the hippocampus, prefrontal
cortex, striatum and cerebral cortex. On the other hand, cerebellum was not affected. 相似文献
6.
Búrigo M Roza CA Bassani C Fagundes DA Rezin GT Feier G Dal-Pizzol F Quevedo J Streck EL 《Neurochemical research》2006,31(11):1375-1379
It is well described that impairment of energy production has been implicated in the pathogenesis of a number of diseases. Although several advances have occurred over the past 20 years concerning the use and administration of electroconvulsive therapy (ECT) to minimize its side effects, little progress has been made in understanding its mechanism of action. In this work, our aim was to measure the activities of mitochondrial respiratory chain complexes II and IV and succinate dehydrogenase from rat brain after acute and chronic electroconvulsive shock (ECS). Our results showed that mitochondrial respiratory chain enzymes activities were increased after acute ECS in hippocampus, striatum and cortex of rats. Besides, we also demonstrated that complex II activity was increased after chronic ECS in cortex, while hippocampus and striatum were not affected. Succinate dehydrogenase, however, was inhibited after chronic ECS in striatum, activated in cortex and not affected in hippocampus. Finally, complex IV was not affected by chronic ECS in hippocampus, striatum and cortex. Our findings demonstrated that brain metabolism is altered by ECS. 相似文献
7.
V A Rezin 《Biulleten' eksperimental'no? biologii i meditsiny》1989,108(11):540-542
In the experiments on white rats resuscitated after a 7-minute mechanical asphyxia, phase disorders in the indices of the system of regulation of aggregate state of the blood in postresuscitation period have been revealed. They appear in the shape of a syndrome of disseminated intravascular blood coagulation with the development of hypercoagulation phase by the 3rd hour. Prophylactic introduction of ionol in a dose of 100 mg/kg in 48, 24 and 1 hour before the experiment prevents the development and progressing of the above syndrome. 相似文献
8.
Mitochondrial Dysfunction and Psychiatric Disorders 总被引:1,自引:0,他引:1
Mitochondrial oxidative phosphorylation is the major ATP-producing pathway, which supplies more than 95% of the total energy
requirement in the cells. Damage to the mitochondrial electron transport chain has been suggested to be an important factor
in the pathogenesis of a range of psychiatric disorders. Tissues with high energy demands, such as the brain, contain a large
number of mitochondria, being therefore more susceptible to reduction of the aerobic metabolism. Mitochondrial dysfunction
results from alterations in biochemical cascade and the damage to the mitochondrial electron transport chain has been suggested
to be an important factor in the pathogenesis of a range of neuropsychiatric disorders, such as bipolar disorder, depression
and schizophrenia. Bipolar disorder is a prevalent psychiatric disorder characterized by alternating episodes of mania and
depression. Recent studies have demonstrated that important enzymes involved in brain energy are altered in bipolar disorder
patients and after amphetamine administration, an animal model of mania. Depressive disorders, including major depression,
are serious and disabling. However, the exact pathophysiology of depression is not clearly understood. Several works have
demonstrated that metabolism is impaired in some animal models of depression, induced by chronic stress, especially the activities
of the complexes of mitochondrial respiratory chain. Schizophrenia is a devastating mental disorder characterized by disturbed
thoughts and perception, alongside cognitive and emotional decline associated with a severe reduction in occupational and
social functioning, and in coping abilities. Alterations of mitochondrial oxidative phosphorylation in schizophrenia have
been reported in several brain regions and also in platelets. Abnormal mitochondrial morphology, size and density have all
been reported in the brains of schizophrenic individuals. Considering that several studies link energy impairment to neuronal
death, neurodegeneration and disease, this review article discusses energy impairment as a mechanism underlying the pathophysiology
of some psychiatric disorders, like bipolar disorder, depression and schizophrenia. 相似文献
9.
Utility of the white gene in estimating phylogenetic relationships among mosquitoes (Diptera: Culicidae) 总被引:2,自引:0,他引:2
The utility of a nuclear protein-coding gene for reconstructing
phylogenetic relationships within the family Culicidae was explored.
Relationships among 13 species representing three subfamilies and nine
genera of Culicidae were analyzed using a 762-bp fragment of coding
sequence from the eye color gene, white. Outgroups for the study were two
species from the sister group Chaoboridae. Sequences were determined from
clone PCR products amplified from genomic DNA, and aligned following
conceptual intron splicing and amino acid translation. Third codon
positions were characterized by high levels of divergence and biased
nucleotide composition, the intensity and direction of which varied among
taxa. Equal weighting of all characters resulted in parsimony and
neighboring-joining trees at odds with the generally accepted phylogenetic
hypothesis based on morphology and rDNA sequences. The application of
differential weighting schemes recovered the traditional hypothesis, in
which the subfamily Anophelinae formed the basal clade. The subfamily
Toxorhynchitinae occupied an intermediate position, and was a sister group
to the subfamily Culicinae. Within Culicinae, the genera Sabethes and
Tripteroides formed an ancestral clade, while the Culex-Deinocerites and
Aedes- Haemagogus clades occupied increasingly derived positions in the
molecular phylogeny. An intron present in the Culicinae- Toxorhynchitinae
lineage and one outgroup taxon was absent in the basal Anophelinae lineage
and the second outgroup taxon, suggesting that intron insertions or
deletions may not always be reliable systematic characters.
相似文献
10.