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Choudhury Amir Sohail Choudhury Parthankar Gassah Rejoice 《Primates; journal of primatology》2022,63(2):173-184
Primates - The Bengal slow loris (Nycticebus bengalensis) is an endangered nonhuman primate distributed in Southeast Asia, including India. The species is facing sharp population decline throughout... 相似文献
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Martin Samuels Gaurav Gulati Jae-Ho Shin Rejoice Opara Elizabeth McSweeney Matt Sekedat Stephen Long Zvi Kelman David Jeruzalmi 《Nucleic acids research》2009,37(13):4441-4452
The mini-chromosome maintenance (MCM) proteins serve as the replicative helicases in archaea and eukaryotes. Interestingly, an MCM homolog was identified, by BLAST analysis, within a phage integrated in the bacterium Bacillus cereus (Bc). BcMCM is only related to the AAA region of MCM-helicases; the typical amino-terminus is missing and is replaced by a segment with weak homology to primases. We show that BcMCM displays 3′→5′ helicase and ssDNA-stimulated ATPase activity, properties that arise from its conserved AAA domain. Isolated BcMCM is a monomer in solution but likely forms the functional oligomer in vivo. We found that the BcMCM amino-terminus can bind ssDNA and harbors a zinc atom, both hallmarks of the typical MCM amino-terminus. No BcMCM-catalyzed primase activity could be detected. We propose that the divergent amino-terminus of BcMCM is a paralog of the corresponding region of MCM-helicases. A divergent amino terminus makes BcMCM a useful model for typical MCM-helicases since it accomplishes the same function using an apparently unrelated structure. 相似文献
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George T. Bicego Rejoice Nkambule Ingrid Peterson Jason Reed Deborah Donnell Henry Ginindza Yen T. Duong Hetal Patel Naomi Bock Neena Philip Cherry Mao Jessica Justman 《PloS one》2013,8(10)
Background
The 2011 Swaziland HIV Incidence Measurement Survey (SHIMS) was conducted as part of a national study to evaluate the scale up of key HIV prevention programs.Methods
From a randomly selected sample of all Swazi households, all women and men aged 18-49 were considered eligible, and all consenting adults were enrolled and received HIV testing and counseling. In this analysis, population-based measures of HIV prevalence were produced and compared against similarly measured HIV prevalence estimates from the 2006-7 Swaziland Demographic and Health. Also, measures of HIV service utilization in both HIV infected and uninfected populations were documented and discussed.Results
HIV prevalence among adults aged 18-49 has remained unchanged between 2006-2011 at 31-32%, with substantial differences in current prevalence between women (39%) and men (24%). In both men and women, between since 2006-7 and 2011, prevalence has fallen in the young age groups and risen in the older age groups. Over a third (38%) of the HIV-infected population was unaware of their infection status, and this differed markedly between men (50%) and women (31%). Of those aware of their HIV-positive status, a higher percentage of men (63%) than women (49%) reported ART use.Conclusions
While overall HIV prevalence remains roughly constant, age-specific changes strongly suggest both improved survival of the HIV-infected and a reduction in new HIV infections. Awareness of HIV status and entry into ART services has improved in recent years but remains too low. This study identifies opportunities to improve both HIV preventive and care services in Swaziland. 相似文献4.
Choudhury Amir Sohail Choudhury Parthankar Gassah Rejoice 《Primates; journal of primatology》2022,63(2):185-186
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