全文获取类型
收费全文 | 497篇 |
免费 | 59篇 |
出版年
2022年 | 3篇 |
2021年 | 7篇 |
2020年 | 4篇 |
2019年 | 6篇 |
2018年 | 8篇 |
2017年 | 12篇 |
2016年 | 8篇 |
2015年 | 17篇 |
2014年 | 30篇 |
2013年 | 26篇 |
2012年 | 28篇 |
2011年 | 29篇 |
2010年 | 23篇 |
2009年 | 23篇 |
2008年 | 22篇 |
2007年 | 24篇 |
2006年 | 25篇 |
2005年 | 29篇 |
2004年 | 14篇 |
2003年 | 13篇 |
2002年 | 18篇 |
2001年 | 13篇 |
2000年 | 15篇 |
1999年 | 11篇 |
1998年 | 4篇 |
1997年 | 8篇 |
1996年 | 3篇 |
1995年 | 7篇 |
1994年 | 5篇 |
1992年 | 6篇 |
1991年 | 29篇 |
1990年 | 9篇 |
1989年 | 8篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 2篇 |
1979年 | 6篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1975年 | 9篇 |
1974年 | 5篇 |
1973年 | 4篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1970年 | 5篇 |
1969年 | 1篇 |
1968年 | 2篇 |
1967年 | 3篇 |
1966年 | 1篇 |
排序方式: 共有556条查询结果,搜索用时 46 毫秒
1.
2.
Isolation and primary structure of rat secretin 总被引:2,自引:0,他引:2
D Gossen A Vandermeers M C Vandermeers-Piret J Rathé A Cauvin P Robberecht J Christophe 《Biochemical and biophysical research communications》1989,160(2):862-867
A major form of rat secretin was purified to homogeneity from small intestine, being detected with a porcine secretin radioimmunoassay throughout 7 chromatographic steps. The sequence of the heptacosapeptide amide H-S-D-G-T-F-T-S-E-L-S-R-L-Q-D-S-A-R-L-Q-R-L-L-Q-G-L-V-NH2 shows that rat secretin has a glutamine residue in position 14 instead of arginine as in pig secretin. 相似文献
3.
Summary Quantitative receptor autoradiography on sections of the human brain raises methodical problems of which some are relevant also for studies in animal tissue, but others are unique in studies of human brain tissue. Procedures for the following methodical aspects are discussed image analysis for quantitation of the regional distribution of receptor densities, saturation analysis on autoradiographs, influence of age and post-mortem delay and quenching of -radiation in brain tissue. The solutions proposed to these problems make receptor autoradiography in the human brain to a reliable method for studies of chemical neuroanatomy. 相似文献
4.
5.
6.
7.
8.
9.
Trimethyloxonium modification of single batrachotoxin-activated sodium channels in planar bilayers. Changes in unit conductance and in block by saxitoxin and calcium 总被引:13,自引:9,他引:4
下载免费PDF全文
![点击此处可从《The Journal of general physiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Single batrachotoxin-activated sodium channels from rat brain were modified by trimethyloxonium (TMO) after incorporation in planar lipid bilayers. TMO modification eliminated saxitoxin (STX) sensitivity, reduced the single channel conductance by 37%, and reduced calcium block of inward sodium currents. These effects always occurred concomitantly, in an all-or-none fashion. Calcium and STX protected sodium channels from TMO modification with potencies similar to their affinities for block. Calcium inhibited STX binding to rat brain membrane vesicles and relieved toxin block of channels in bilayers, apparently by competing with STX for the toxin binding site. These results suggest that toxins, permeant cations, and blocking cations can interact with a common site on the sodium channel near the extracellular surface. It is likely that permeant cations transiently bind to this superficial site, as the first of several steps in passing inward through the channel. 相似文献
10.