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Mingyue Wang Pranab K Mukherjee Jyotsna Chandra Ali Abdul Lattif Thomas S McCormick Mahmoud A Ghannoum 《BMC microbiology》2008,8(1):31
Background
We have previously shown that supernatant from Candida albicans (CA) culture contains a Secretory Interleukin (IL)-12 Inhibitory Factor (CA-SIIF), which inhibits IL-12 production by human monocytes. However, the effect of CA-SIIF on secretion of other cytokines by monocytes is unknown, and detailed characterization of this factor has not been performed. 相似文献5.
Barakaeli Abdieli Ndosi Hansol Park Dongmin Lee Seongjun Choe Yeseul Kang Tilak Chandra Nath Mohammed Mebarek Bia Chatanun Eamudomkarn Hyeong-Kyu Jeon Keeseon S. Eom 《The Korean journal of parasitology》2020,58(6):653
Spirometra tapeworms (Cestoda: Diphyllobothriidae) collected from carnivorous mammals in Tanzania were identified by the DNA sequence analysis of the mitochondrial cytochrome c oxidase subunit 1 (cox1) and internal transcribed spacer 1 (ITS1), and by morphological characteristics. A total of 15 adult worms were collected from stool samples and carcasses of Panthera leo, Panthera pardus, and Crocuta crocuta in the Serengeti and Selous ecosystems of Tanzania. Three Spirometra species: S. theileri, S. ranarum and S. erinaceieuropaei were identified based on morphological features. Partial cox1 sequences (400 bp) of 10 specimens were revealed. Eight specimens showed 99.5% similarity with Spirometra theileri (), 1 specimen showed 99.5% similarity with the Korean S. erinaceieuropaei and 1 specimen had 99.5% similarity with Myanmar S. ranarum. Sequence homology estimates for the ITS1 region of S. theileri were 89.8% with S. erinaceieuropaei, 82.5% with S. decipiens, and 78.3% with S. ranarum; and 94.4% homology was observed between S. decipiens and S. ranarum. Phylogenetic analyses were performed with 4 species of Spirometra and 2 species of Dibothriocephalus (=Diphyllobothrium). By both ML and BI methods, cox1 and ITS1 gave well supported, congruent trees topology of S. erinaceieuropaei and S. theileri with S. decipiens and S. ranarum forming a clade. The Dibothriocephalus species were sisters of each other and collectively forming successive outgroups. Our findings confirmed that 3 Spirometra species (S. theileri, S. ranarum, and S. erinaceieuropaei) are distributed in the Serengeti and Selous ecosystems of Tanzania. MK955901相似文献
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Uranium (U) tolerant aerobic heterotrophs were isolated from the subsurface soils of one of the pre-mined U-rich deposits at Domiasiat located in the north-eastern part of India. On screening of genomic DNA from 62 isolates exhibiting superior U and heavy metal tolerance, 32 isolates were found to be positive for PIB-type ATPase genes. Phylogenetic incongruence and anomalous DNA base compositions revealed the acquisition of PIB-type ATPase genes by six isolates through horizontal gene transfer (HGT). Three of these instances of HGT appeared to have occurred at inter-phylum level and the other three instances indicated to have taken place at intra-phylum level. This study provides an insight into one of the possible survival strategies that bacteria might employ to adapt to environments rich in uranium and heavy metals. 相似文献
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S K Tandon A K Mathur J R Behari S V Chandra 《Acta biologica et medica Germanica》1975,34(11-12):1835-1842
Daily intraperitoneal administration of thorium nitrate produced progressive morphological and biochemical alterations with the increase in thorium concentration in rat testis. The degenerative changes in the seminiferous tubules increased with the duration of treatment and after 90 days calcification occurred in about 25% of the tubules and in the connective tissue of the tunica albuginea. The activity of adenosine triphosphatase and alkaline phosphatase increased markedly as a result of thorium administration. An attempt has been made to interrelate histopathological and enzymatic changes and the metal concentration in the testicular tissue. 相似文献
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Ram Kothandan 《Bioinformation》2015,11(1):6-10
MiRNAs are small (~22nt long) non-coding RNA sequences; binds to the complementarity target sites in 3'' Untranslated Region
(UTR) of mRNA sequences but not restricted to other mRNA regions viz., 5'' UTR and Coding sequences (CDS). Complementarity
binding of miRNA to mRNA target sites either results in complete degradation of the mRNA itself or it may regulate the mRNA as
an oncogene or as a tumor suppressor gene. However, the exact mechanism involved in identifying a miRNA to be associated with
cancer is still unclear. Further, with the outburst in the number of miRNAs sequences recorded every year in miRBase, the gap is
still widening mainly due to the laborious and economically unfavorable experimental procedures associated with the functional
annotation. Motivated by the fact, we constructed a two-step support vector machine-based predictive model - miRSEQ and
miRINT. However, the major pitfall during the construction of the model is the class imbalance problem. Hence, in order to
overcome class imbalance problem, in the present study we empirically compare the effectiveness of two different methods viz.,
Synthetic Minority Oversampling Technique (SMOTE) and cost-senstive learning method. Performance measures were evaluated
in terms of Precision and Recall. Based on our result, it was observed that for miRNA dataset with high class imbalance utilized for
predicting association of cancer, cost-sensitive method outperformed the oversampling method. 相似文献