全文获取类型
收费全文 | 222篇 |
免费 | 26篇 |
国内免费 | 4篇 |
专业分类
252篇 |
出版年
2023年 | 1篇 |
2022年 | 4篇 |
2021年 | 4篇 |
2020年 | 5篇 |
2019年 | 7篇 |
2018年 | 11篇 |
2017年 | 8篇 |
2016年 | 9篇 |
2015年 | 16篇 |
2014年 | 13篇 |
2013年 | 11篇 |
2012年 | 26篇 |
2011年 | 15篇 |
2010年 | 13篇 |
2009年 | 6篇 |
2008年 | 21篇 |
2007年 | 10篇 |
2006年 | 9篇 |
2005年 | 9篇 |
2004年 | 7篇 |
2003年 | 6篇 |
2002年 | 5篇 |
2001年 | 6篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1991年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有252条查询结果,搜索用时 15 毫秒
1.
2.
Genetically modified (GM) cotton altered for insect and herbicide resistance released into commercial production in 1996 to 1997 now accounts for the lion's share of cotton acreage in the U.S. The rapid increase in transgenic cotton acreage in such a short period of time attests to the overall success of agricultural biotechnology. Grower satisfaction with transgenic cotton is largely due to several significant benefits, such as lower production costs, streamlined yet flexible management, and a reduced impact on the environment. This review article provides an overview of what has been accomplished thus far, as well as what improved germplasm may lurk on the horizon. A critical assessment of the gene delivery systems in cotton and possible targets for improvement is presented. The performance of the first generation of transgenic cotton plants engineered for insect, disease, or herbicide resistance is evaluated from the perspective of the benefits, the limitations that impact field performance, and management strategies. A few traits that hold future promise for increasing fiber productivity, enhancing and/or increasing the novelty of cotton-based products for the consumer, and improving human health and well-being are presented. Above all, cotton biotechnology offers to greatly enhance breeding programs by introducing novel traits that have eluded more traditional plant improvement methods and therefore will likely play an increasingly important role in the genetic improvement of cotton. 相似文献
3.
4.
5.
6.
Sekar P. Chandra Rajasekaran R. 《International journal of peptide research and therapeutics》2021,27(2):1043-1056
International Journal of Peptide Research and Therapeutics - Initial phase of COVID-19 infection is associated with the binding of viral spike protein S1 receptor binding domain (RBD) with the host... 相似文献
7.
C. George Priya Doss B. Rajith R. Rajasekaran Jain Srajan N. Nagasundaram C. Debajyoti 《Cell biochemistry and biophysics》2013,67(3):1307-1318
Polymorphisms in the human prion proteins lead to amino acid substitutions by the conversion of PrPC to PrPSc and amyloid formation, resulting in prion diseases such as familial Creutzfeldt–Jakob disease, Gerstmann–Straussler–Scheinker disease and fatal familial insomnia. Cation–π interaction is a non-covalent binding force that plays a significant role in protein stability. Here, we employ a novel approach by combining various in silico tools along with molecular dynamics simulation to provide structural and functional insight into the effect of mutation on the stability and activity of mutant prion proteins. We have investigated impressions of prevalent mutations including 1E1S, 1E1P, 1E1U, 1E1P, 1FKC and 2K1D on the human prion proteins and compared them with wild type. Structural analyses of the models were performed with the aid of molecular dynamics simulation methods. According to our results, frequently occurred mutations were observed in conserved sequences of human prion proteins and the most fluctuation values appear in the 2K1D mutant model at around helix 4 with residues ranging from 190 to 194. Our observations in this study could help to further understand the structural stability of prion proteins. 相似文献
8.
Moore J. Rajasekaran K. Cary J. W. Chlan C. 《International journal of peptide research and therapeutics》2019,25(3):1135-1145
International Journal of Peptide Research and Therapeutics - The synthetic, linear peptide, D4E1, demonstrates antimicrobial activity against a broad spectrum of organisms including the toxigenic... 相似文献
9.
10.
Increasing death rates due to antibiotic resistance deteriorate the existing treatment measures. Antimicrobial peptides have turned into the emerging cure for multidrug resistance. However, the stability and functionality determine an antimicrobial peptide as a drug. Analyses of the homodimeric β-helical peptide, gramicidin have suggested the significant role of gramicidin-A, gramicidin-B, and gramicidin-C as antimicrobial compounds, but the structural basis for understanding the stability and functionality is insufficient to resolve multidrug resistance. To identify the best template among gramicidin types as a therapeutic product, we combined a detailed comparative static analysis and dynamic analysis along with conformational free energy and secondary structure prediction. We observed that the high intramolecular interactions and the geometrical features favored gramicidin-A among other types of gramicidin. Our analyses further revealed that the secondary structure of gramicidin-A showed β sheets with coils along the conformations without any disruption, thereby enhanced its membrane interactions in terms of binding free energy. In conclusion, gramicidin-A has definitely showed enhanced structural stability and functionality; this could be considered the best template for a potential therapeutic product. 相似文献