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Amir Ali Rahsepar Asadollah Mirzaee Fatemeh Moodi Mohsen Moohebati Shima Tavallaie Fatemeh Khorashadizadeh Ali Eshraghi Maryam-Sadat Alavi Laya Zarrabi Mostafa Sajjadian Maral Amini Roshanak Khojasteh Roghayeh Paydar Somayeh Mousavi Majid Ghayour-Mobarhan Gordon A. Ferns 《Cell stress & chaperones》2013,18(1):65-74
The relationship between serum anti-heat shock protein (Hsp)27 antibody and high sensitive C-reactive protein (hs-CRP) levels and indices of cardiac function were investigated in patients undergoing coronary artery bypass grafting (CABG) or heart valve replacement. The changes in anti-Hsp27 antibody titers and hs-CRP levels were compared among patients undergoing off-pump and on-pump CABG or valvular heart replacement. Fifty-three patients underwent off-pump, on-pump CABG, and heart valvular replacement in each group. Serum anti-Hsp27 titers and hs-CRP values were measured 24 h before and after the operation and at discharge. Echocardiography was performed before surgery and before discharge. The results were compared with values from 83 healthy controls. hs-CRP levels increased and anti-Hsp27 antibody decreased following surgery (P < 0.001 and P < 0.05, respectively), although these changes were independent of operative procedure (P = 0.361 and P = 0.120, respectively). Anti-Hsp27 antibody levels were higher at the time of discharge (P = 0.016). Only in coronary patients were anti-Hsp27 antibody levels negatively associated with E/E′ (r = −0.268, P = 0.022), a marker of pulmonary capillary wedge pressure. In conclusions, anti-Hsp27 antibody levels are associated with indices of cardiac function in coronary patients. Cardiopulmonary bypass had no significant effect on the induction of changes in anti-Hsp27 levels. Moreover, anti-Hsp27 antibody levels fell in all groups postoperatively; this may be due to the formation of immune complexes of antigen–antibody, and antibody levels were higher at the time of discharge.
Electronic supplementary material
The online version of this article (doi:10.1007/s12192-012-0358-y) contains supplementary material, which is available to authorized users. 相似文献2.
Atena Soleimani Mostafa Amirinejad Sara Rahsepar Fatemeh Vazirian Afsane Bahrami Gordon A. Ferns Majid Khazaei Amir Avan Seyed Mahdi Hassanian 《Journal of cellular biochemistry》2019,120(5):6860-6867
Breast cancer is one of the most prevalent malignancies among women around the world. RAS proteins require posttranslational modifications, including protein prenylation for proper membrane localization and signaling. Regulation of RAS signaling via specific and novel pharmacological inhibitors is a potentially novel therapeutic approach in breast cancer therapy. This review summarizes the recent knowledge about the clinical value of RAS prenylation pharmacological inhibitors in breast cancer treatment. 相似文献
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Kanafchian Maryam Esmaeilzadeh Sedigheh Mahjoub Soleiman Rahsepar Maryam Ghasemi Maryam 《Biological trace element research》2020,193(1):111-117
Biological Trace Element Research - This study evaluates serum copper and magnesium and total antioxidant capacity levels in PCOS patients. In this regard, the probable association of copper and... 相似文献
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