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排序方式: 共有103条查询结果,搜索用时 15 毫秒
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Rajesh V Elamaran M Vidya S Gowrishankar M Kochar D Das A 《Experimental parasitology》2007,116(3):252-256
Malaria parasites exhibit sequence diversity for a number of stage specific antigens. Several studies have proved that apical membrane antigen-1 (AMA-1) is an effective target for eliciting a protective immune response in humans and other experimental animals. We have investigated the sequence variation in Plasmodium vivax AMA-1 (Pv AMA-1) from different Indian isolates. This is the first study of its kind for the nearly full length Pv AMA-1 from India. Our analysis reveals greater degree of genetic diversity in Pv AMA-1 than reported so far and identifies five novel haplotypes. This is significant to establish the antigenic repertoire of isolates in a malaria endemic country like India. 相似文献
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Ribozymes are RNA molecules capable of associating with other RNA molecules through base-pairing and catalyzing various reactions involving phosphate group transfer. Of particular interest to us is the well known ribozyme from Tetrahymena thermophila capable of catalyzing RNA splicing in eukaryotic systems, chiefly because of its potential use as a gene therapy agent. In this article we review the progress made towards visualizing the RNA splicing mediated by the Tetrahymena ribozyme in single living mammalian cells with the beta-lactamase reporter system and highlight the development made in imaging RNA splicing with the luciferase reporter system in living animals. 相似文献
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Wang X Shao Z Zetoune FS Zeidler MG Gowrishankar K Vincenz C 《Cell death and differentiation》2003,10(5):580-591
NRADD (neurotrophin receptor alike death domain protein) is a novel protein with transmembrane and cytoplasmic regions highly homologous to death receptors, particularly p75(NTR). However, the short N-terminal domain is unique. Expression of NRADD induced apoptosis in a number of cell lines. The apoptotic mechanism involved the activation of caspase-8 and execution of apoptosis without requiring mitochondrial components. The activation of this death receptor-like mechanism required the N-terminal domain, which is N-glycosylated and needed for subcellular targeting. Deletion of the N-terminal domain produced a dominant-negative form of NRADD that protected neurons and Schwann cells from a variety of endoplasmic reticulum (ER) stressors. NRADD may therefore be a necessary component for generating an ER-induced proapoptotic signal. 相似文献
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Ramadurai Gowrishankar Manish Kumar Vinay Menon Sai Mangala Divi M. Saravanan P. Magudapathy B. K. Panigrahi K. G. M. Nair K. Venkataramaniah 《Biological trace element research》2010,133(3):357-363
Traditionally, Tinospora cordifolia (Willd.) Hook. F. & Thomson (Menispermaceae), Ocimum sanctum L. (Lamiaceae), Moringa oleifera Lam. (Moringaceae), and Phyllanthus niruri L. (Euphorbiaceae) are some of the commonly used medicinal plants in India for curing ailments ranging from common cold,
skin diseases, and dental infections to major disorders like diabetes, hypertension, jaundice, rheumatism, etc. To understand
and correlate their medicinal use, trace element studies on the aqueous extract of these medicinal plants have been carried
out using particle-induced X-ray emission technique. A 2-MeV proton beam was used to identify and characterize major and minor
elements namely Cl, K, Ca, Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, Br, and Sr in them. Results have revealed that these elements are
present in varying concentrations in the selected plants. Notable results include very high concentrations of Cl, K, and Ca
in all the leaf samples, appreciable levels of Mn in all plants, high Zn content in T. cordifolia, and the aqueous extract of Moringa leaves compared to others and relative higher concentrations of Cr in all the plants. 相似文献
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