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The transport into and release of14C-labeled niacin and niacinamide from rabbit brain slices and isolated choroid plexuses were studied. In vitro, both brain slices and choroid plexus concentrated 14C by specific, energy-dependent mechanisms when [14C]niacinamide was added to the incubation medium. The saturable accumulation velocities, which were linear for 30 min, depended, in part, on incorporation of the [14C]niacinamide into NAD. The XT and Ymax for 14C accumulation with [14C]niacinamide in the medium by brain slices and choroid plexus were 0.80 μM and 1.45 μmolkg?1 (30 min)?1, and 0.23 μM and 18.6 μmol kg?1 (30 min)?1 respectively. In vitro, the choroid plexus, unlike brain slices, vigorously concentrated 14C by a separate, specific energy-dependent process when 14C niacin was added to the incubation medium. The saturable accumulation velocity, which was linear for 30 min, depended completely on the metabolism of [14C]niacin. The KT and Ymax for14C accumulation by choroid plexus with [14C]niacin in the medium were 18.1 μM and 439 μmol kg?1 (30 min)?1 respectively. Whether preincubated in [14C]niacin or [14C]niacinamide, choroid plexus released predominantly [14C]niacinamide.  相似文献   
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