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Di Fabio R Alvaro G Bertani B Donati D Pizzi DM Gentile G Pentassuglia G Giacobbe S Spada S Ratti E Corsi M Quartaroli M Barnaby RJ Vitulli G 《Bioorganic & medicinal chemistry letters》2007,17(5):1176-1180
Chiral tetrahydroquinoline derivatives have been prepared by an asymmetric Mannich-type condensation reaction using commercially available vinyloxyethylsilane and a N-arylimino R-(+)-t-butyl lactate ester, in the presence of a catalytic amount of metal triflates as Lewis acids. This synthetic approach gave rise to the target aldehyde intermediate in moderate facial diastereoselectivity and in high chemical yield. This efficient route enabled to scale up the synthesis of an orally bioavailable glycine antagonist showing outstanding in vivo anti-hyperalgesic activity in different animal models of sustained inflammation and chronic neuropathic pain. 相似文献
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Quartaroli Larissa Silva Lívia C. Fidélis Silva Claudio Mudadu Lima Helena Santiago de Paula Sergio Oliveira de Oliveira Valéria Maia de Cássia S. da Silva Marliane Kasuya Maria Catarina M. de Sousa Maíra Paula Torres Ana Paula R. Souza Rodrigo Suhett Bassin João Paulo da Silva Cynthia Canêdo 《Applied microbiology and biotechnology》2017,101(2):859-870
Applied Microbiology and Biotechnology - Water generated during oil exploration is chemically complex and contains high concentrations of ammonium and, in some cases, high salinity. The most common... 相似文献
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Micheli F Fabio RD Cavanni P Rimland JM Capelli AM Chiamulera C Corsi M Corti C Donati D Feriani A Ferraguti F Maffeis M Missio A Ratti E Paio A Pachera R Quartaroli M Reggiani A Sabbatini FM Trist DG Ugolini A Vitulli G 《Bioorganic & medicinal chemistry》2003,11(2):171-183
Metabotropic glutamate receptors (mGluRs) are an unusual family of G-protein coupled receptor (GPCR), and are characterised by a large extracellular N-terminal domain that contains the glutamate binding site. We have identified a new class of non-competitive metabotropic glutamate receptor 1 (mGluR1) antagonists, 2,4-dicarboxy-pyrroles which are endowed with nanomolar potency. They interact within the 7 transmembrane (7TM) domain of the receptor and show antinociceptive properties when tested in a number of different animal models. 相似文献
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Daiane R.B. Belgini Virgínia M. Siqueira Douglas M. Oliveira Samantha G. Fonseca Viviane Piccin-Santos Roberto S. Dias Larissa Quartaroli Rodrigo S. Souza Ana Paula R. Torres Maíra P. Sousa Cláudio M. Silva Cynthia C. Silva Sérgio O. De Paula Valéria M. Oliveira 《Systematic and applied microbiology》2018,41(5):473-486
Oil refineries are known for the large volume of water used in their processes, as well as the amount of wastewater generated at the end of the production chain. Due to strict environmental regulations, the recycling of water has now become a viable alternative for refineries. Among the many methods available to treat wastewater for reuse, the use of membranes in reverse osmosis systems stands out due to several economic and environmental benefits. However, these systems are vulnerable to contamination and deposition of microorganisms, mainly because of the feedwater quality. In this study, the microbial diversity of feedwater and reverse osmosis membranes was investigated using a combination of culture-dependent and culture-independent methods in order to characterize the microorganisms colonizing and deteriorating the membranes. In total, 37 bacterial isolates, 17 filamentous fungi and approximately 400 clones were obtained and analyzed. Among the bacterial genera identified, the most represented were Sphingobium, Acidovorax, Microbacterium, Rhizobium and Shinella. The results revealed genera that acted as candidate key players in initial biofilm formation in membrane systems, and provided important information concerning the microbial ecology of oligotrophic aquatic systems. 相似文献
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