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Khalid Hussain Wali Sait Mutaib Mashraqi Asim Abdulaziz Khogeer Othman Alzahrani Nisreen M Anfinan Hesham Khalid Sait Abdulrahman Almutairi Qamre Alam 《Bioinformation》2020,16(11):882
The human epidermal growth factor (HER2) is a transmembrane receptor that is highly expressed in breast cancer and in different other cancers. Therefore, it is of interest to identify the new HER2 inhibitors from a selected 300 compounds in the ZINC database. The top two hit compounds (ZINC000014780728 (-11.0 kcal/mol) and ZINC000014762512 (-10.8 kcal/mol)) showed a high affinity with HER2 relative to the reference compound (lapatinib (-10.2 kcal/mol)) for further consideration. 相似文献
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Tarique Mohammed Ahmad Shaban Malik Arshi Ahmad Irfan Saeed Mohd Almatroudi Ahmad Qadah Talal Murad Manal Abdulaziz Mashraqi Mutaib Alam Qamre Al-Saleh Yousef 《Molecular and cellular biochemistry》2021,476(5):2203-2217
Molecular and Cellular Biochemistry - Novel strain of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) causes mild to severe respiratory illness. The early symptoms may be fever, dry... 相似文献
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Mohammad Zubair Alam Qamre Alam Asif Jiman-Fatani Mohammad Amjad Kamal Adel M. Abuzenadah Adeel G. Chaudhary Mohammad Akram Absarul Haque 《World journal of microbiology & biotechnology》2014,30(5):1437-1451
The incidence of Candida infections have increased substantially in recent years due to aggressive use of immunosuppressants among patients. Use of broad-spectrum antibiotics and intravascular catheters in the intensive care unit have also attributed with high risks of candidiasis among immunocompromised patients. Among Candida species, C. albicans accounts for the majority of superficial and systemic infections, usually associated with high morbidity and mortality often caused due to increase in antimicrobial resistance and restricted number of antifungal drugs. Therefore, early detection of candidemia and correct identification of Candida species are indispensable pre-requisites for appropriate therapeutic intervention. Since blood culture based methods lack sensitivity, and species-specific identification by conventional method is time-consuming and often leads to misdiagnosis within closely related species, hence, molecular methods may provide alternative for accurate and rapid identification of Candida species. Although, several molecular approaches have been developed for accurate identification of Candida species but the internal transcribed spacer 1 and 2 (ITS1 and ITS2) regions of the rRNA gene are being used extensively in a variety of formats. Of note, ITS sequencing and PCR–RFLP analysis of ITS region seems to be promising as a rapid, easy, and cost-effective method for identification of Candida species. Here, we review a number of existing techniques ranging from conventional to molecular approaches currently in use for the identification of Candida species. Further, advantages and limitations of these methods are also discussed with respect to their discriminatory power, reproducibility, and ease of performance. 相似文献
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Assessment of IL‐18 Serum Level and Its Promoter Polymorphisms in the Saudi Coronary Artery Disease (CAD) Patients
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