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In the recent past, huge emphasis has been given to the epigenetic alterations of the genes responsible for the cause of neurological disorders. Earlier, the scientists believed somatic changes and modifications in the genetic makeup of DNA to be the main cause of the neurodegenerative diseases. With the increase in understanding of the neural network and associated diseases, it was observed that alterations in the gene expression were not always originated by the change in the genetic sequence. For this reason, extensive research has been conducted to understand the role of epigenetics in the pathophysiology of several neurological disorders including Alzheimer’s disease, Parkinson’s disease and, Huntington’s disease. In a healthy person, the epigenetic modifications play a crucial role in maintaining the homeostasis of a cell by either up-regulating or down-regulating the genes. Therefore, improved understanding of these modifications may provide better insight about the diseases and may serve as potential therapeutic targets for their treatment. The present review describes various epigenetic modifications involved in the pathology of Parkinson’s Disease (PD) backed by multiple researches carried out to study the gene expression regulation related to the epigenetic alterations. Additionally, we will briefly go through the current scenario about the various treatment therapies including small molecules and multiple phytochemicals potent enough to reverse these alterations and the future directions for a better management of PD.
相似文献Pollen assemblages closely reflect the local vegetation that characterizes the salinity status, providing useful analogs for paleoecologxical reconstruction in regional deposits. Palynological evidences of surface sediments from the Coringa mangrove wetland were correlated with the physicochemical and sediment salinity records to observe the relationship between them. The statistical analysis of the data obtained here revealed a marked horizontal salinity gradient from north to south.. In this study, ordination (detrended correspondence analysis) of palynomorph groups has identified a salinity gradient of 1.1 to 3.0 PSU from the north to the south in the wetland. High palynomorph deposition and lower salinity are observed along channel margins due to the mixing of estuarine water during the rainy season. The mudflats along the transects show a lower diversity of plants in the pollen record and high total dissolved solids (TDS) than commonly found in the coastal wetlands. The presence of scrubby halophytic vegetation in the upper saltmarsh and oligohaline-freshwater vegetation in the low tidal saline marshes is a zonation pattern related to the localized influence of freshwater conditions. Palynomarine Index (PMI) reveals the highest freshwater/tidal inundation along Ramannapalem due to the presence of numerous riverine channels while the remaining part of the wetland has restricted tidal inundation leading to the conversion of mangrove forests to salt pans and paddy fields. Thus, the health and productivity of the mangrove ecosystem are also governed by hydrodynamics, catchment land use, water discharge in the channels, and tidal flushing.
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