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William J. Pope 《BMJ (Clinical research ed.)》1923,1(3254):833-834
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Nine schizophrenic patients participated in a study which explored whether EEG feedback techniques could effect changes in the EEG similar to those associated with neuroleptic-induced improvement. During five sessions, each patient was presented feedback signals which continuously refected the discrepancy between characteristics of the patient's EEG power spectral profile and spectral profile characteristics associated by past research with neuroleptic induced clinical improvement. Significant within-session changes were observed for two of three EEG power spectrum bands of interest. No significant session-to-session EEG changes were observed. The results suggest that the EEG of schizophrenics can be temporarily altered, using feedback techniques, in a way that mimics the EEG changes that have been shown to occur with neuroleptic induced clinical improvement.The authors are indebted to Turan M. Itil, John W. Fredrickson, Michael Madwed, and Irene B. Francis. Senior authorship is shared equally. 相似文献
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I I Shekhter V P Ve?ko M T Bulenkov K I Ratmanova V G Debabov 《Molekuliarnaia biologiia》1991,25(1):153-161
The mutant forms of human IFN-alpha 2 gene are obtained by oligonucleotide-directed mutagenesis with the use of uracil-repair system. To intensify the process the procedure of the uracil-containing DNA template preparation is modified. It was determined that when mutagenesis is performed in the uracil-repair system the yield of the process depends on the mutant DNA-strand in vitro synthesis efficiency. It is shown that the stability of the 5'-end primer-template complex and the level of the endogenic primers elongation are the basis factors, that determine induction mutations. 相似文献
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Regulation of natural killer cell activity by macrophages in the rheumatoid joint and peripheral blood 总被引:3,自引:0,他引:3
B Combe R Pope B Darnell W Kincaid N Talal 《Journal of immunology (Baltimore, Md. : 1950)》1984,133(2):709-713
Recently, in another study, we observed that indomethacin, a prostaglandin synthetase inhibitor, significantly increased NK activity in both normal and rheumatoid arthritis (RA) peripheral blood (PB) but not in RA synovial fluid (SF). Because macrophages are a major source of prostaglandins, we examined the effect of macrophage-enriched adherent cells (AC) on NK activity as measured by a 3-hr Cr-release assay with K 562 cells. The removal of AC resulted in increased (p less than 0.01) NK activity in both normal and RA PB. In contrast, the removal of AC from RA SF resulted in a significant decrease (p less than 0.001) of NK activity. By using only nonadherent cells (NAC), NK activity in RA SF and synovial tissue (ST) was significantly reduced when compared to autologous RA PB (p less than 0.001). Enhancement of NK activity of SF NAC by both poly I:C and IL 2 was not dependent on AC. Mixing experiments demonstrated that the addition of synovial AC for 16 hr increased NK activity of synovial NAC to a level similar to that of unseparated mononuclear cells, whereas autologous PB AC suppressed NK activity of PB NAC. PB AC, when added to SF NAC, also increased NK activity. Supernatants from synovial mononuclear cells were stimulatory of synovial NAC NK activity, whereas normal PB mononuclear supernatants were suppressive. These observations document 1) a significant reduction of NAC-mediated NK activity in the rheumatoid joint as compared to PB from the same patient, and 2) that AC modulate NK activity differently in the rheumatoid joint as compared to RA or normal PB. 相似文献
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S S Bo?ko V P Zherdev A A Dvorianinov I Janku E Buchar 《Biulleten' eksperimental'no? biologii i meditsiny》1990,110(11):501-503
Pharmacokinetics of novel immunostimulating drug kamantane was studied by using gas-liquid chromatography in experiments on rats. It was found that kemantane biotransformed rapidly after oral administration with the forming of active metabolite. Kemantane and its metabolites are distributed rapidly from the blood to organs. The drug is eliminated from the organism of rats as metabolite. 相似文献
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Comparative phylogeography of two co‐distributed but ecologically distinct rainbowfishes of far‐northern Australia 下载免费PDF全文
Andrew T. Mather Jeffrey O. Hanson Lisa C. Pope Cynthia Riginos 《Journal of Biogeography》2018,45(1):127-141