Prognostic role of EGR1 in breast cancer: a systematic review

EGR1 (early growth response 1) is dysregulated in many cancers and exhibits both tumor suppressor and promoter activities, making it an appealing target for cancer therapy. Here, we used a systematic multiomics analysis to review the expression of EGR1 and its role in regulating clinical outcomes in breast cancer (BC). EGR1 expression, its promoter methylation, and protein expression pattern were assessed using various publicly available tools. COSMIC-based somatic mutations and cBioPortal-based copy number alterations were analyzed, and the prognostic roles of EGR1 in BC were determined using Prognoscan and Kaplan-Meier Plotter. We also used bc-GenEx-Miner to investigate the EGR1 co-expression profile. EGR1 was more often downregulated in BC tissues than in normal breast tissue, and its knockdown was positively correlated with poor survival. Low EGR1 expression levels were also associated with increased risk of ER+, PR+, and HER2-BCs. High positive correlations were observed among EGR1, DUSP1, FOS, FOSB, CYR61, and JUN mRNA expression in BC tissue. This systematic review suggested that EGR1 expression may serve as a prognostic marker for BC patients and that clinicopathological parameters influence its prognostic utility. In addition to EGR1, DUSP1, FOS, FOSB, CYR61, and JUN can jointly be considered prognostic indicators for BC.     

Arsenic Remediation in Bangladeshi Rice Varieties with Enhance Plant Growth by Unique Arsenic-Resistant Bacterial Isolates

Abstract

Arsenic (As) pollution is one of the major threats to public health in Bangladesh, where daily intake of As per person exceeds the World Health Organization recommended level. Plants can assimilate significant quantities of As on a daily basis. Consumption of rice contaminated with As from soil and irrigation water can elevate the daily As intake in humans. In this study, we aimed to identify indigenous As-tolerant bacteria with the ability to use different carbon and nitrogen sources to enhance plant growth through siderophore and indole-3-acetic acid (IAA) formation, and with the ability to absorb, store, transform, and remediate As. Three As-tolerant plant growth-promoting bacteria were isolated: Bacillus sp. (GIS1) (MG203916), Acinetobacter sp. (GIS3) (MG203917), and Acinetobacter sp. (GIS5) (MG203918). They were confirmed by 16s rDNA sequencing and scanning electron microscopy. The bacteria showed a positive response to plant growth and As absorbing capacity. Especially, strain GIS1 (MG203916) and GIS 3(MG203917) showed a great potential for the bioremediation of As pollution, which might have potential agricultural and microbiological implications.     

Salicylic Acid-Mediated Enhancement of Photosynthesis Attributes and Antioxidant Capacity Contributes to Yield Improvement of Maize Plants Under Salt Stress

Journal of Plant Growth Regulation - Addressing salinity-induced crop losses is a prime concern of modern agriculture to sustain agricultural productivity, thereby contributing to global food...     

Decolorization,degradation and detoxification of carcinogenic sulfonated azo dye methyl orange by newly developed biofilm consortia

Metabolites of azo dyes are often carcinogenic, teratogenic, mutagenic and recalcitrant in nature. In this study, four biofilm consortia such as C1 (Vitreoscilla sp. ENSG301, Acinetobacter lwoffii ENSG302, Klebsiella pneumoniae ENSG303 and Pseudomonas fluorescens ENSG304), C2 (Escherichia coli ENSD101, Enterobacter asburiae ENSD102 and E. ludwigii ENSH201), C3 (E. asburiae ENSD102, Vitreoscilla sp. ENSG301 and Bacillus thuringiensis ENSW401), and C4 (E. coli ENSD101, E. ludwigii ENSH201 and B. thuringiensis ENSW401) were applied to degrade and detoxify methyl orange (MO), a carcinogenic, sulfonated mono azo dye, used in textile dyeing industry worldwide. The consortia of C1, C2, C3 and C4 showed 97.30, 98.75, 99.51 and 99.29% decolorization, respectively in yeast extract peptone (YEP) broth containing 200 mg L⁻¹ MO within 60 h of incubation in static condition. The optimum pH and temperature for decolorization was 7.0 and 28 °C, respectively. Some divalent metal ions including Mg²⁺, Ca²⁺, Zn²⁺ and Mn²⁺ could stimulate MO decolorization. UV–Vis spectral analysis showed that the absorption peak at 465 nm originated from the azo (N N) bond was completely disappeared within 60 h of incubation. Fourier transform infrared spectroscopy (FTIR) results also revealed that several major peaks including azo bond peak at 1602.6 cm⁻¹ are completely or partly vanished, deformed or shifted. Activities of azoreductase, NADH-DCIP reductase and laccase were significantly increased in the bacterial cells within 60 h of incubation in comparison to that of control (0 h). The chemical oxygen demand was incredibly reduced by 85.37 to 91.44% by these consortia. Accordingly, plant (wheat seed germination) and microbial (growth of the plant probiotic bacteria such as Pseudomonas cedrina ESR12 and Bacillus cereus ESD3 on biodegraded products) toxicity studies showed that biodegraded products of MO are non-toxic. Thus, all these consortia can be utilized in bioremediation of MO from wastewater for safe disposal into environment. To our knowledge, this is the first report on degradation and detoxification of MO from wastewater by bacterial biofilm consortia.