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Valentina V. Miroshnikova Ekaterina A. Polyakova Irina A. Pobozheva Aleksandra A. Panteleeva Natalia D. Razgildina Diana A. Kolodina Olga D. Belyaeva Olga A. Berkovich Sofya N. Pchelina Elena I. Baranova 《Genetics and molecular biology》2021,44(4)
Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD. 相似文献
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Panteleeva A. A. Razgildina N. D. Brovin D. L. Pobozheva I. A. Dracheva K. V. Berkovich O. A. Polyakova E. A. Belyaeva O. D. Baranova E. I. Pchelina S. N. Miroshnikova V. V. 《Molecular Biology》2021,55(1):56-65
Molecular Biology - The study aimed to investigate tissue-specific gene expression of ABCA1 and ABCG1, encoding cholesterol transporters, as well as PPARG, LXRβ (NR1H2), and RORA, encoding the... 相似文献
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