Kidney homogenate, a test medium to determine the inhibitory effect of antimycotics on yeasts.

The test procedure described in this paper aims at assessing the effectiveness of antimycotics against yeasts. The inhibitory effect on Candida albicans growth is determined in the presence of kidney homogenate, an in vitro test medium offering fungal growth conditions similar to physiological conditions. The inoculum consists of kidney material from Candida-infected mice. By dilution with kidney material from uninfected mice the initial number of viable particles is standardised. Specimens withdrawn from this inoculum are mixed with different concentrations of the test substance and incubated for 24 hours. The inhibition of fungal growth is assessed on the basis of the number of colony-forming units in comparison with controls to which no test substance was added. The growth phase of C. albicans during incubation in vitro resembles that observed in the kidney in vivo, i.e. besides yeast cells, the fungus produces a great number of pseudomycelia and mycelia. The results of the tests conducted with the top-ranking antimycotics give good evidence of their therapeutic efficacy. The testing of further active substances revealed advantages of the new test model over existing test methods.     

Die zygotropische Reaktion der Mucorineen

Ohne ZusammenfassungMit 10 Textabbildungen     

Die chemischen Grundlagen der Sexualreaktion bei Zygomyceten

Ohne ZusammenfassungMit 7 TextabbildungenHerrn Prof. Dr. Dr. h.c.Adolf Butenandt zum 60. Geburtstag.     

Die Sexualstoffe der Mucoraceae

Ohne ZusammenfassungGekürzte Dissertation der Naturwissenschaftlichen Fakultät der Universität Würzburg, 1956.     

Sexualreaktion und Carotin-Synthese bei Zygomyceten

Zusammenfassung Gamonbildung und Carotinsynthese sind bei den Zygomyceten Mucor mucedo, Blakeslea trispora und Phycomyces Blakesleeanus gekoppelte Reaktionen. Die Gamonbildung verläuft parallel zur Carotinbiosynthese. Damit kann ein Weg zur Klärung der Gamonsynthese gefunden werden.

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Sexual reaction and carotene synthesis in Zygomycetes

Summary In the Zygomycetes Mucor mucedo, Blakeslea trispora and Phycomyces Blakesleeanus, gamon formation and carotene synthesis are coupled reactions. The gamon formation goes parallel with the carotene biosynthesis. This provides a way by which gamon synthesis can be elucidated.