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Early Regional Response of Apoptotic Activity in Newborn Piglet Brain Following Hypoxia and Ischemia
A. Pirzadeh A. Mammen J. Kubin E. Reade H. Liu A. Mendoza W. J. Greeley D. F. Wilson A. Pastuszko 《Neurochemical research》2011,36(1):83-92
Responses of selected neuroregulatory proteins that promote (Caspase 3 and Bax) or inhibit (Bcl-2, high Bcl-2/Bax ratio) apoptotic
cell death were measured in the brain of piglets subjected to precisely controlled hypoxic and ischemic insults: 1 h hypoxia
(decreasing FiO2 from 21 to 6%) or ischemia (ligation of carotid arteries and hemorrhage), followed by 0, 2 and 4 h recovery with 21% FiO2. Protein expression was measured in cortex, hippocampus and striatum by Western blot. There were no significant differences
in expression of Caspase-3 between sham operated, hypoxic and ischemic groups. There were significant regional differences
in expression of Bcl-2 and Bax in response to hypoxia and ischemia. The changes in Bcl-2/Bax ratio were similar for hypoxia
and ischemia except for striatum at zero time recovery, with ischemia giving lower ratios than hypoxia. The Bcl-2/Bax ratio
was also lower for the striatum than for the other regions of the brain, suggesting this region is the more susceptible to
apoptotic injury. 相似文献
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Derakhshan Samira Aminishakib Pouyan Pirzadeh Fatemeh Rahrotaban Sedigheh Farzaneh Parvaneh Tavakoli Shiraji Sahar Ganjibakhsh Meysam Asadi Masoumeh 《Molecular biology reports》2021,48(4):3223-3235
Molecular Biology Reports - Aflibercept and arsenic trioxide drugs apply a cytotoxic effect on some human cancer cell lines. However, no more study has followed the effects of both drugs,... 相似文献
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