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Yu-Tao Xiang Robert W. Buchanan Gabor S. Ungvari Helen F. K. Chiu Kelly Y. C. Lai You-Hong Li Tian-Mei Si Chuan-Yue Wang Edwin H. M. Lee Yan-Ling He Shu-Yu Yang Mian-Yoon Chong Ee-Heok Kua Senta Fujii Kang Sim Michael K. H. Yong Jitendra K. Trivedi Eun-Kee Chung Pichet Udomratn Kok-Yoon Chee Norman Sartorius Chay-Hoon Tan Naotaka Shinfuku 《PloS one》2013,8(6)
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Geoffrey M. Reed Michael B. First Cary S. Kogan Steven E. Hyman Oye Gureje Wolfgang Gaebel Mario Maj Dan J. Stein Andreas Maercker Peter Tyrer Angelica Claudino Elena Garralda Luis Salvador‐Carulla Rajat Ray John B. Saunders Tarun Dua Vladimir Poznyak María Elena Medina‐Mora Kathleen M. Pike Jos L. Ayuso‐Mateos Shigenobu Kanba Jared W. Keeley Brigitte Khoury Valery N. Krasnov Maya Kulygina Anne M. Lovell Jair de Jesus Mari Toshimasa Maruta Chihiro Matsumoto Tahilia J. Rebello Michael C. Roberts Rebeca Robles Pratap Sharan Min Zhao Assen Jablensky Pichet Udomratn Afarin Rahimi‐Movaghar Per‐Anders Rydelius Sabine Bhrer‐Kohler Ann D. Watts Shekhar Saxena 《World psychiatry》2019,18(1):3-19
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Pichet Termsarasab Thananan Thammongkolchai Ju Gao Luwen Wang Jingjing Liang Xinglong Wang 《Experimental biology and medicine (Maywood, N.J.)》2020,245(17):1584
Transactive response DNA binding protein 43 (TDP-43) pathologies have been well recognized in various neurodegenerative disorders including frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD). However, there have been limited studies on whether there are any TDP-43 alterations in normal aging. We investigated TDP-43 distribution in different brain regions in normal aged (n = 3 for 26- or 36-month-old) compared to young (n = 3 for 6- or 12-month-old) mice. In both normal aged and young mice, TDP-43 and phosphorylated TDP-43 (pTDP-43) demonstrated a unique pattern of distribution in neurons in some specific brain regions including the pontine nuclei, thalamus, CA3 region of the hippocampus, and orbital cortex. This pattern was demonstrated on higher magnification of high-resolution double fluorescence images and confocal microscopy as mislocalization of TDP-43 and pTDP-43, characterized by neuronal nuclear depletion and cytoplasmic accumulation in these brain regions, as well as colocalization between TDP-43 or pTDP-43 and mitochondria, similar to what has been described previously in neurodegenerative disorders. All these findings were identical in both normal aged and young mice. In summary, TDP-43 and pTDP-43 mislocalization from nucleus to cytoplasm and their colocalization with mitochondria in the specific brain regions are present not only in aging, but also in young healthy states. Our findings provide a new insight for the role of TDP-43 proteinopathy in health and diseases, and that aging may not be a critical factor for the development of TDP-43 proteinopathy in subpopulations of neurons.Impact statementDespite increasing evidence implicating the important role of TDP-43 in the pathogenesis of a wide range of age-related neurodegenerative diseases, there is limited study of TDP-43 proteinopathy and its association with mitochondria during normal aging. Our findings of cytoplasmic accumulation of TDP-43 that is highly colocalized with mitochondria in neurons in selective brain regions in young animals in the absence of neuronal loss provide a novel insight into the development of TDP-43 proteinopathy and its contribution to neuronal loss. 相似文献
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Lurchachaiwong W Junyangdikul P Payungporn S Sampatanukul P Chansaenroj J Tresukosol D Termrungruanglert W Niruthisard S Poovorawan Y 《The new microbiologica》2011,34(2):147-156
Cervical cytological data may not be sufficient for cervical cancer screening and prevention. In this project, we determined HPV genotype among infected Thai women with different cytological findings by characterization of E1 genes. Five hundred and thirty-five specimens were tested by PCR amplification of the E1 genes. HPV genotypes were determined by sequencing, comparison with the GenBank database and were analyzed in relation to different cytological findings. HPV-DNA by PCR were typed and revealed 32 different genotypes. HR-HPV (HPV16, 18 or 52) was detected in all samples with cervical cancer cytology. HPV16 was most prevalent irrespective of cervical cytology. Moreover, HPV31 and 52 were most prevalent in the HSIL and LSIL groups whereas HPV66 was found mostly in the LSIL group. The LSIL group displayed the highest variation of HPV genotypes. Moreover, HPV31 and 52 predominated in the HSIL and LSIL groups especially HPV52 which was found in cancer samples. We hoped that these data of HPV genotypes can be used as preliminary data of HPV in Thailand and can serve as basic data for future research into the HPV genotype in south-east Asia. 相似文献
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The objectives of this study were to prepare push–pull osmotic tablets (PPOT) of felodipine using an interpolymer complex
of chitosan (CS) and poly(acrylic acid) (PAA) as an osmopolymer, and to study the mechanisms of drug release from these tablets.
The interpolymer complexes were prepared with different weight ratios of CS to PAA. Preparation of PPOT involved the fabrication
of bilayered tablets with the drug layer, containing felodipine, polyethylene oxide, and the polymeric expansion layer, containing
the CS–PAA complex. The effects of polymer ratios, type of plasticizers, and compression forces on release characteristics
were investigated. It was found that drug release from PPOT exhibited zero-order kinetics and could be prolonged up to 12
or 24 h depending on the plasticizer used. PPOT using dibutyl sebacate showed a longer lag time and slower drug release than
that using polyethylene glycol 400. In the case of polyethylene glycol 400, an increase in the CS proportion resulted in an
increase in the drug release rate. The compression force had no effect on drug release from PPOT. Drug release was controlled
by two consecutive mechanisms: an osmotic pump effect resulting in the extrusion of the drug layer from the tablet and subsequent
erosion and dissolution of the extruded drug layer in the dissolution medium. The mathematical model (zero-order) related
to extrusion and erosion rates for describing the mechanism of drug release showed a good correlation between predicted and
observed values. 相似文献
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Weera Mahavanakul Emma K. Nickerson Pramot Srisomang Prapit Teparrukkul Pichet Lorvinitnun Mingkwan Wongyingsinn Wirongrong Chierakul Maliwan Hongsuwan T. Eoin West Nicholas P. Day Direk Limmathurotsakul Sharon J. Peacock 《PloS one》2012,7(2)
Background
The Surviving Sepsis Campaign (SSC) guidelines describe best practice for the management of severe sepsis and septic shock in developed countries, but most deaths from sepsis occur where healthcare is not sufficiently resourced to implement them. Our objective was to define the feasibility and basis for modified guidelines in a resource-restricted setting.Methods and Findings
We undertook a detailed assessment of sepsis management in a prospective cohort of patients with severe sepsis caused by a single pathogen in a 1,100-bed hospital in lower-middle income Thailand. We compared their management with the SSC guidelines to identify care bundles based on existing capabilities or additional activities that could be undertaken at zero or low cost. We identified 72 patients with severe sepsis or septic shock associated with S. aureus bacteraemia, 38 (53%) of who died within 28 days. One third of patients were treated in intensive care units (ICUs). Numerous interventions described by the SSC guidelines fell within existing capabilities, but their implementation was highly variable. Care available to patients on general wards covered the fundamental principles of sepsis management, including non-invasive patient monitoring, antimicrobial administration and intravenous fluid resuscitation. We described two additive care bundles, one for general wards and the second for ICUs, that if consistently performed would be predicted to improve outcome from severe sepsis.Conclusion
It is feasible to implement modified sepsis guidelines that are scaled to resource availability, and that could save lives prior to the publication of international guidelines for developing countries. 相似文献9.
Genome-wide association analysis for nine agronomic traits in maize under well-watered and water-stressed conditions 总被引:2,自引:0,他引:2
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C. Mir T. Zerjal V. Combes F. Dumas D. Madur C. Bedoya S. Dreisigacker J. Franco P. Grudloyma P. X. Hao S. Hearne C. Jampatong D. Laloë Z. Muthamia T. Nguyen B. M. Prasanna S. Taba C. X. Xie M. Yunus S. Zhang M. L. Warburton A. Charcosset 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》2013,126(11):2671-2682
Maize was first domesticated in a restricted valley in south-central Mexico. It was diffused throughout the Americas over thousands of years, and following the discovery of the New World by Columbus, was introduced into Europe. Trade and colonization introduced it further into all parts of the world to which it could adapt. Repeated introductions, local selection and adaptation, a highly diverse gene pool and outcrossing nature, and global trade in maize led to difficulty understanding exactly where the diversity of many of the local maize landraces originated. This is particularly true in Africa and Asia, where historical accounts are scarce or contradictory. Knowledge of post-domestication movements of maize around the world would assist in germplasm conservation and plant breeding efforts. To this end, we used SSR markers to genotype multiple individuals from hundreds of representative landraces from around the world. Applying a multidisciplinary approach combining genetic, linguistic, and historical data, we reconstructed possible patterns of maize diffusion throughout the world from American “contribution” centers, which we propose reflect the origins of maize worldwide. These results shed new light on introductions of maize into Africa and Asia. By providing a first globally comprehensive genetic characterization of landraces using markers appropriate to this evolutionary time frame, we explore the post-domestication evolutionary history of maize and highlight original diversity sources that may be tapped for plant improvement in different regions of the world. 相似文献
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