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Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice 总被引:15,自引:0,他引:15
Di Paolo G Sankaranarayanan S Wenk MR Daniell L Perucco E Caldarone BJ Flavell R Picciotto MR Ryan TA Cremona O De Camilli P 《Neuron》2002,33(5):789-804
The function of the clathrin coat in synaptic vesicle endocytosis is assisted by a variety of accessory factors, among which amphiphysin (amphiphysin 1 and 2) is one of the best characterized. A putative endocytic function of amphiphysin was supported by dominant-negative interference studies. We have now generated amphiphysin 1 knockout mice and found that lack of amphiphysin 1 causes a parallel dramatic reduction of amphiphysin 2 selectively in brain. Cell-free assembly of endocytic protein scaffolds is defective in mutant brain extracts. Knockout mice exhibit defects in synaptic vesicle recycling that are unmasked by stimulation and suggest impairments at multiple stages of the cycle. These defects correlate with increased mortality due to rare irreversible seizures and with major learning deficits, suggesting a critical role of amphiphysin for higher brain functions. 相似文献
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Carbognani Michele Bernareggi Giulietta Perucco Francesco Tomaselli Marcello Petraglia Alessandro 《Oecologia》2016,182(2):573-585
Oecologia - Alpine snowbed communities are among the habitats most threatened by climate change. The warmer temperature predicted, coupled with advanced snowmelt time, will influence flowering... 相似文献
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