排序方式: 共有115条查询结果,搜索用时 15 毫秒
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Mahaki Hanie Saeed Modaghegh Mohammad Hadi Nasr Isfahani Zeynab Amir Daddost Rahele Molaei Pejman Ahmadyousefi Yaghoub Vahidzadeh Masoomeh Lotfiane Elham Tanzadehpanah Hamid 《International journal of peptide research and therapeutics》2021,27(4):2527-2542
International Journal of Peptide Research and Therapeutics - Recently, peptide-based materials have been applied to solving many therapeutic problems and have shown particular efficacy as cancer... 相似文献
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Akram Eidi Pejman Mortazavi Khodabakhsh Behzadi Ali Haeri Rohani Shahabeddin Safi 《Biological trace element research》2013,155(2):267-275
The aim of the present study is to evaluate the protective effect of manganese chloride against carbon tetrachloride (CCl4)-induced liver injury in rats. Manganese chloride (0.001, 0.01, 0.05 and 0.1 g/kg bw) was administered intragastrically for 28 consecutive days to male CCl4-treated rats. The hepatoprotective activity was assessed using various biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltransferase (GGT) and superoxide dismutase (SOD). Histopathological changes in the liver of different groups were also studied. Administration of CCl4 increased the serum ALT, AST, ALP and GGT but decreased SOD levels in rats. Treatment with manganese chloride significantly attenuated these changes to nearly normal levels. The animals treated with manganese chloride have shown decreased necrotic zones and hepatocellular degeneration when compared to the liver exposed to CCl4 intoxication alone. Thus, the histopathalogical studies also supported the protective effect of manganese chloride. Therefore, the results of this study suggest that manganese chloride exerts hepatoprotection via promoting antioxidative properties against CCl4-induced oxidative liver damage. 相似文献
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Population dynamics models remain largely deterministic, although the presence of random fluctuations in nature is well recognized. This deterministic approach is based on the implicit assumption that systems can be separated into a deterministic part that captures the essential features of the system and a random part that can be neglected. But is it possible, in general, to understand population dynamics without the explicit consideration of random fluctuations? Here, we suggest perhaps not, and argue that the dynamics of many systems are a result of interactions between the deterministic nonlinear skeleton and noise. 相似文献
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Burkart V Kim YE Hartmann B Ghiea I Syldath U Kauer M Fingberg W Hanifi-Moghaddam P Müller S Kolb H 《Journal of immunology (Baltimore, Md. : 1950)》2002,168(4):1730-1737
The cholera toxin B chain (CTB) has been reported to suppress T cell-dependent autoimmune diseases and to potentiate tolerance of the adaptive immune system. We have analyzed the effects of CTB on macrophages in vitro and have found that preincubation with CTB (10 microg/ml) suppresses the proinflammatory reaction to LPS challenge, as demonstrated by suppressed production of TNF-alpha, IL-6, IL-12(p70), and NO (p < 0.01) in cells of macrophage lines. Pre-exposure to CTB also suppresses LPS-induced TNF-alpha and IL-12(p70) formation in human PBMC. Both native and recombinant CTB exhibited suppressive activity, which was shared by intact cholera toxin. In cells of the human monocyte line Mono Mac 6, exposure to CTB failed to suppress the production of IL-10 in response to LPS. Control experiments excluded a role of possible contamination of CTB by endotoxin or intact cholera toxin. The suppression of TNF-alpha production occurred at the level of mRNA formation. Tolerance induction by CTB was dose and time dependent. The suppression of TNF-alpha and IL-6 production could be counteracted by the addition of Abs to IL-10 and TGF-beta. IFN-gamma also antagonized the actions of CTB on macrophages. In contrast to desensitization by low doses of LPS, tolerance induction by CTB occurred silently, i.e., in the absence of a measurable proinflammatory response. These findings identify immune-deviating properties of CTB at the level of innate immune cells and may be relevant to the use of CTB in modulating immune-mediated diseases. 相似文献
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Ale-Ebrahim Mahsa Rahmani Raziyeh Faryabi Kousar Mohammadifar Niloofar Mortazavi Pejman Karkhaneh Leyla 《Molecular biology reports》2022,49(5):3433-3443
Molecular Biology Reports - The effects of trans-chalcone on atherosclerosis and NAFLD have been investigated. However, the underlying molecular mechanisms of these effects are not completely... 相似文献
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Bakhtiyariniya Pejman Khosravi Azar Dokht Hashemzadeh Mohammad Savari Mohammad 《Molecular biology reports》2022,49(7):6135-6143
Molecular Biology Reports - The global rise in drug-resistant Mycobacterium tuberculosis (M.tb), and especially the significant prevalence of isoniazid (INH)-resistance constitute a significant... 相似文献
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Aaron A. King Matthieu Domenech de Cellès Felicia M. G. Magpantay Pejman Rohani 《Proceedings. Biological sciences / The Royal Society》2015,282(1806)
As an emergent infectious disease outbreak unfolds, public health response is
reliant on information on key epidemiological quantities, such as transmission
potential and serial interval. Increasingly, transmission models fit to
incidence data are used to estimate these parameters and guide policy. Some
widely used modelling practices lead to potentially large errors in parameter
estimates and, consequently, errors in model-based forecasts. Even more
worryingly, in such situations, confidence in parameter estimates and forecasts
can itself be far overestimated, leading to the potential for large errors that
mask their own presence. Fortunately, straightforward and computationally
inexpensive alternatives exist that avoid these problems. Here, we first use a
simulation study to demonstrate potential pitfalls of the standard practice of
fitting deterministic models to cumulative incidence data. Next, we demonstrate
an alternative based on stochastic models fit to raw data from an early phase of
2014 West Africa Ebola virus disease outbreak. We show not only that bias is
thereby reduced, but that uncertainty in estimates and forecasts is better
quantified and that, critically, lack of model fit is more readily diagnosed. We
conclude with a short list of principles to guide the modelling response to
future infectious disease outbreaks. 相似文献
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BackgroundMathematical models have become invaluable management tools for epidemiologists, both shedding light on the mechanisms underlying observed dynamics as well as making quantitative predictions on the effectiveness of different control measures. Here, we explain how substantial biases are introduced by two important, yet largely ignored, assumptions at the core of the vast majority of such models.ConclusionThis work aims to highlight that, when developing models for public health use, we need to pay careful attention to the intrinsic assumptions embedded within classical frameworks. 相似文献
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Matthew H. Bonds Donald C. Keenan Pejman Rohani Jeffrey D. Sachs 《Proceedings. Biological sciences / The Royal Society》2010,277(1685):1185-1192
While most of the world has enjoyed exponential economic growth, more than one-sixth of the world is today roughly as poor as their ancestors were many generations ago. Widely accepted general explanations for the persistence of such poverty have been elusive and are needed by the international development community. Building on a well-established model of human infectious diseases, we show how formally integrating simple economic and disease ecology models can naturally give rise to poverty traps, where initial economic and epidemiological conditions determine the long-term trajectory of the health and economic development of a society. This poverty trap may therefore be broken by improving health conditions of the population. More generally, we demonstrate that simple human ecological models can help explain broad patterns of modern economic organization. 相似文献