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Dimitra C. Benaki Eugenia Paxinou Vassiliki Magafa George N. Pairas Evy Manessi-Zoupa Paul A. Cordopatis Emmanuel Mikros 《Letters in Peptide Science》2001,8(2):77-87
The nonapeptide Leuprorelin, one of the LHRH agonists, was studied by means of 2D nuclear magnetic resonance spectroscopy and molecular modeling. NOESY spectra in aqueous/deuterated methanol solution (50%H2O/CD3OD) at low temperature (268 K) revealed short-range nOe connectivities (i, i+1), characteristic of flexibility of the molecule. The HN–HN sequential connectivities observed provide evidence that the sequence has the propensity to form a bend involving residues 5 and 6 and the N-terminal segment. The -proton chemical shifts compared to random coil and additional data from the amide proton temperature coefficients support this assumption. One long-range nOe cross peak between H2
–HNEth is indicative of proximity between C- and N-termini. 相似文献
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Benaki Dimitra C. Paxinou Eugenia Magafa Vassiliki Pairas George N. Manessi-Zoupa Evy Cordopatis Paul A. Mikros Emmanuel 《International journal of peptide research and therapeutics》2001,8(2):77-87
Summary The nonapeptide Leuprorelin, one of the LHRH agonists, was studied by means of 2D nuclear magnetic resonance spectroscopy
and molecular modeling. NOESY spectra in aqueous/deuterated methanol solution (50% H2O/CD3OD) at low temperature (268 K) revealed short-range nOe connectivities (i, i+1), characteristic of flexibility of the molecule.
The H
N
-H
N
sequential connectivities observed provide evidence that the sequence has the propensity to form a bend involving residues
5 and 6 and the N-terminal segment. The α-proton chemical shifts compared to random coil and additional data from the amide
proton temperature coefficients support this assumption. One long-range nOe cross peak between H
2
α
-H
NEth
is indicative of proximity between C- and N-termini. 相似文献
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