全文获取类型
收费全文 | 7855篇 |
免费 | 340篇 |
国内免费 | 1篇 |
出版年
2023年 | 40篇 |
2022年 | 30篇 |
2021年 | 88篇 |
2020年 | 99篇 |
2019年 | 125篇 |
2018年 | 295篇 |
2017年 | 266篇 |
2016年 | 342篇 |
2015年 | 245篇 |
2014年 | 360篇 |
2013年 | 549篇 |
2012年 | 441篇 |
2011年 | 615篇 |
2010年 | 359篇 |
2009年 | 218篇 |
2008年 | 400篇 |
2007年 | 456篇 |
2006年 | 476篇 |
2005年 | 408篇 |
2004年 | 348篇 |
2003年 | 382篇 |
2002年 | 301篇 |
2001年 | 190篇 |
2000年 | 161篇 |
1999年 | 108篇 |
1998年 | 66篇 |
1997年 | 30篇 |
1996年 | 13篇 |
1995年 | 21篇 |
1994年 | 15篇 |
1993年 | 13篇 |
1991年 | 21篇 |
1987年 | 14篇 |
1985年 | 28篇 |
1984年 | 23篇 |
1983年 | 17篇 |
1982年 | 16篇 |
1981年 | 14篇 |
1979年 | 22篇 |
1978年 | 20篇 |
1977年 | 19篇 |
1955年 | 29篇 |
1954年 | 77篇 |
1953年 | 60篇 |
1952年 | 67篇 |
1951年 | 20篇 |
1950年 | 56篇 |
1949年 | 12篇 |
1888年 | 14篇 |
1887年 | 14篇 |
排序方式: 共有8196条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
Rafał Krętowski Anna Stypułkowska Marzanna Cechowska-Pasko 《Molecular and cellular biochemistry》2015,398(1-2):165-173
The inhibition of the 26S proteasome evokes endoplasmic reticulum stress, which has been shown to be implicated in the antitumoral effects of proteasome inhibitors. The cellular and molecular effects of the proteasome inhibitor—bortezomib—on human colon cancer cells are as yet poorly characterized. Bortezomib selectively induces apoptosis in some cancer cells. However, the nature of its selectivity remains unknown. Previously, we demonstrated that, in contrast to normal fibroblasts, bortezomib treatment evoked strong effect on apoptosis of breast cancer cells incubated in hypoxic and normoxic conditions. The study presented here provides novel information on the cellular effects of bortezomib in DLD-1 colon cancer cells line. We observe twofold higher percentage of apoptotic cells incubated for 48 h with 25 and 50 nmol/l of bortezomib in hypoxic conditions and four-, fivefold increase in normoxic conditions in comparison to control cells, incubated without bortezomib. It is of interest that bortezomib evokes strong effect on necrosis of DLD-1 colon cancer cell line. We observe the sixfold increase in necrosis of DLD-1 cells incubated with 25 or 50 nmol/l of bortezomib for 48 h in hypoxia and fourfold increase in normoxic conditions in comparison to adequate controls. We suggest that bortezomib may be candidates for further evaluation as chemotherapeutic agents for human colon cancer. 相似文献
9.
10.
Jacek Kęsy Beata Maciejewska Magdalena Sowa Magdalena Szumilak Krzysztof Kawałowski Maja Borzuchowska Jan Kopcewicz 《Plant Growth Regulation》2008,55(1):43-50
It has been shown that both IAA and ethylene application inhibit flower induction in the short-day plant Pharbitis nil. However application of IAA has elevated ethylene production in this plant, as well. Strong enhancement of ethylene production
is also correlated with the night-break effect, which completely inhibits flowering. In order to determine what the role of
IAA and ethylene is in the photoperiodic flower induction in Pharbitis nil, we measured changes in their levels during inductive and non-inductive photoperiods, and the effects of ethylene biosynthesis
and action inhibitors on inhibition of flowering by IAA. Our results have shown that the inhibitory effect of IAA on Pharbitis nil flowering is not physiological but is connected with its effect on ethylene biosynthesis. 相似文献