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Tohno Y Tohno S Mahakkanukrauh P Minami T Sinthubua A Suwannahoy P Khanpetch P Azuma C 《Biological trace element research》2012,145(3):275-282
To clarify the manner of accumulation of Ca and P in the coronary arteries, the authors divided the coronary arteries into
many segments based on arterial ramification and investigated the element contents of the segments by direct chemical analysis.
After ordinary dissection at Chiang Mai University was finished, the left coronary (LC) and the right coronary (RC) arteries
were removed successively from the hearts of Thai subjects. The Thai subjects consisted of seven men and five women, ranging
in age from 42 to 87 years (average age = 73.9 ± 13.5 years). The LC and the RC arteries were divided into 19 segments based
on arterial ramification. After incineration with nitric acid and perchloric acid, element contents of the segments were analyzed
by inductively coupled plasma–atomic emission spectrometry. In two cases, a significant content of Ca and P was contained
only in the left anterior descending (LAD) artery (type I). In four cases, a significant content of Ca and P was contained
in both the LAD and the RC arteries (type II). In five cases, a significant content of Ca and P was contained in all the LAD,
the RC, and the circumflex (CF) arteries (type III). In the other one case, no significant content of Ca and P was contained
in the coronary arteries. The manner of accumulation of Ca and P in the coronary arteries was classified into the three types,
I, II, and III. Regarding the average content of elements in 12 cases, the average content of Ca was the highest in the segment
of the LAD artery ramifying the first left diagonal artery and was higher in the proximal and distal adjacent segments of
the LAD artery ramifying the first left diagonal artery, the proximal segment of the RC artery, and the proximal segment of
the CF artery. To examine an effect of arterial ramification on accumulation of Ca and P, the differences in the Ca and P
content between artery-ramifying and non-ramified proximal or distal segments of the coronary arteries were analyzed with
Student’s t test. It was found that there were no significant differences in the Ca and P content between the artery-ramifying and non-ramified
proximal or distal segments of the coronary arteries. 相似文献
3.
Setsuko Tohno Nutcharin Ongkana Lining Ke Pasuk Mahakkanukrauh Takeshi Minami Patipath Suwannahoy Apichat Sinthubua Yoshiyuki Tohno 《Biological trace element research》2010,137(1):40-48
To examine whether there were gender differences in the various brain regions, the authors investigated the gender differences
in seven element contents of the anterior commissure, mammillary body, and olfactory bulb and tract by direct chemical analysis.
After ordinary dissection at Nara Medical University was finished, the anterior commissures, mammillary bodies, and olfactory
bulbs and tracts were resected from the cerebra cut at median line. The brain samples were treated with 99.5% ethanol three
times to remove lipids. After ashing with nitric acid and perchloric acid, the seven element contents Ca, P, S, Mg, Zn, Fe,
and Na were determined by inductively coupled plasma–atomic emission spectrometry. It was found that the Zn content was significantly
higher in the anterior commissures of men than in those of women. In the olfactory bulbs and tracts, it was found that the
Ca, P, and Zn contents were significantly higher in men than in women. In contrast, no significant difference was found between
the mammillary bodies of men and women regarding the seven element contents. 相似文献
4.
Yoshiyuki Tohno Setsuko Tohno Cho Azuma Nutcharin Ongkana Pasuk Mahakkanukrauh Takeshi Minami Patipath Suwannahoy Kittikun Viwatpinyo Lining Ke 《Biological trace element research》2013,152(2):161-173
To elucidate the compositional changes of the amygdala with aging, the authors investigated age-related differences of elements in human amygdalae. In addition, the relationships between the amygdala and other brain regions were investigated from a viewpoint of elements. After ordinary dissections at Nara Medical University were finished, the amygdalae were removed from the cerebra of the subjects who consisted of 22 men and 23 women, ranging in age from 70 to 101 years. In addition, the hippocampus, dentate gyrus, mammillary body of the limbic system and the caudate nucleus, putamen, and globus pallidus of the basal ganglia were also removed from the identical cerebra. After the brain samples were incinerated with nitric acid and perchloric acid, the element contents were determined by inductively coupled plasma-atomic emission spectrometry. It was found that both the Ca and Mg contents increased significantly in the amygdalae with aging, but the other five element contents (P, S, Zn, Fe, and Na) did not change significantly in the amygdalae with aging. Regarding the relationships among elements, very significant or significant direct correlations were found among the Ca, P, and Mg contents in the amygdalae. To explore the relationships between the amygdala and either other limbic system or basal ganglia, the correlations between seven elements of the amygdala and hippocampus, dentate gyrus, or mammillary body, and between those of the amygdala and caudate nucleus, putamen, or globus pallidus which derived from the identical cerebra, were analyzed with Pearson’s correlation. It was found that regarding the four elements of Ca, P, Mg, and Fe, a close relationship existed between the amygdala and hippocampus, globus pallidus, or mammillary body. 相似文献
5.
Yoshiyuki Tohno Setsuko Tohno Nutcharin Ongkana Patipath Suwannahoy Cho Azuma Takeshi Minami Apichat Sinthubua Pasuk Mahakkanukrauh 《Biological trace element research》2011,140(1):35-52
To elucidate the relationships among the brain regions belonging to the limbic system, the authors investigated the relationships
among the hippocampus, dentate gyrus, mammillary body, and fornix, using the anterior commissure as a control, from a viewpoint
of elements. After ordinary dissections at Nara Medical University were finished, the hippocampi, dentate gyri, mammillary
bodies, fornices, and anterior commissures were resected from identical cerebra of the subjects. The subjects consisted of
23 men and 23 women, ranging in age from 70 to 101 years (average age = 83.5 ± 7.5 years). After ashing with nitric acid and
perchloric acid, element contents were determined by inductively coupled plasma-atomic emission spectrometry. With regard
to seven elements of Ca, P, S, Mg, Zn, Fe, and Na, it was examined whether there were significant correlations among the hippocampus,
dentate gyrus, mammillary body, fornix, and anterior commissure. It was found that there were extremely or very significant
direct correlations among all of the five brain regions of the hippocampus, dentate gyrus, mammillary body, fornix, and anterior
commissure in the P content. Likewise, with regard to the Fe content, there were significant direct correlations among the
four brain regions belonging to the limbic system, except for the anterior commissure. In both the Ca and Zn contents, there
were extremely or very significant direct correlations among the hippocampus, dentate gyrus, and mammillary body of the gray
matter. 相似文献
6.
Tohno S Kobayashi M Shimizu H Tohno Y Suwannahoy P Azuma C Minami T Sinthubua A Mahakkanukrauh P 《Biological trace element research》2009,127(3):211-227
To elucidate compositional changes of the prostate with aging, the authors investigated age-related changes of elements in
the prostates and the relationships among their elements using Japanese and Thai. After ordinary dissections by students at
Nara Medical University and Chiang Mai University were finished, the prostates were resected from the subjects. Fifty-seven
Japanese subjects ranged in age from 65 to 101 years (average age = 82.5 ± 7.8 years), whereas 13 Thai subjects ranged in
age from 43 to 86 years (average age = 67.9 ± 11.9 years). After ashing with nitric acid and perchloric acid, element contents
were determined by inductively coupled plasma–atomic emission spectrometry. It was found that although there were no significant
correlations between age and seven element contents, such as Ca, P, S, Mg, Zn, Fe, and Na, in the prostates of Japanese, high
contents of Ca (>5 mg/g) and P (>4 mg/g) were contained in one fourth of the prostates of Japanese over 70 years of age. In
the prostates of Thai, a significant direct correlation was found between age and Ca content, but it was not found between
age and the other element contents, such as P, S, Mg, Zn, Fe, and Na. Regarding the relationships among their elements, extremely
significant direct correlations were found among the contents of Ca, P, Mg, Zn, and Na in the prostates of Japanese. In the
prostates of Thai, significant direct correlations were found among the contents of Ca, Mg, and Zn, but no significant correlations
were found between Ca and P contents and between P and Mg contents. Regarding the relationships among their elements, there
were differences between the prostates of Japanese and Thai. To examine whether element contents changed in prostatic hypertrophy,
the transverse width of the Japanese prostates was measured. No significant correlations were found between the transverse
width and element contents, such as Ca, P, S, Mg, Zn, Fe, and Na, in the Japanese prostates. Therefore, it is unlikely that
the increase of elements results in prostatic hypertrophy. 相似文献
7.
Yoshiyuki Tohno Patipath Suwanahoy Setsuko Tohno Apicha Sinthubua Cho Azuma Fumio Nishiwaki Yumi Moriwake Tsukasa Kumai Takeshi Minami Sikrai Laowatthanaphong Pasuk Mahakkanukrauh Takao Oishi Motoharu Hayashi 《Biological trace element research》2010,133(3):291-303
To elucidate compositional changes of the tendon of the peroneus longus muscle with aging, the authors investigated age-related changes of elements in the insertion of tendons of the peroneus longus muscle (peroneus longus tendons) in Thai, Japanese, and monkeys and the relationships among element contents by direct chemical analysis. After ordinary dissections at Chiang Mai University and Nara Medical University were finished, the peroneus longus tendons were resected from the subjects. The peroneus longus tendons were also resected from rhesus and Japanese monkeys bred in Primate Research Institute, Kyoto University. The wraparound regions of the insertion tendons of the peroneus longus muscle in contact with the cuboid bone were used as the peroneus longus tendon. After ashing with nitric acid and perchloric acid, element contents were determined with an inductively coupled plasma-atomic emission spectrometer. It was found that there were no significant correlations between age and the seven elements, such as Ca, P, S, Mg, Zn, Fe, and Na, in the peroneus longus tendons of Thai and Japanese. The Ca content higher than 10 mg/g was contained in seven cases out of 34 peroneus longus tendons of Thai (incidence?=?20.6%) and in one case out of 22 peroneus longus tendons of Japanese (incidence?=?4.5%), respectively. All of the peroneus longus tendons with the Ca content higher than 10 mg/g were found in Thai and Japanese men. In the peroneus longus tendons of monkeys, the Ca and P content increased suddenly at 2 years of age and reached to about 40 mg/g at 5 years of age. Thereafter, the Ca and P content did not increase in the peroneus longus tendons of monkeys at old age. Regarding the relationships among element contents, significant direct correlations were found among the contents of Ca, P, Mg, Zn, and Na in Thai and monkeys, whereas significant inverse correlations were found between S and element contents, such as Ca, P, Mg, Zn, and Na, in Thai and monkeys. 相似文献
8.
Tohno Y Tohno S Mahakkanukrauh P Minami T Sinthubua A Suwannahoy P Ongkana N Laowatthanaphong S Azuma C 《Biological trace element research》2011,144(1-3):17-26
To examine whether there were gender differences in compositional changes of the coronary artery with aging, the authors investigated the gender difference in age-related changes of elements in the left coronary arteries of Thais by direct chemical analysis. After ordinary dissections by students at Chiang Mai University were finished, the left coronary arteries were resected from Thai subjects. The Thai subjects consisted of 69 men and 34 women. The ages of the male subjects ranged from 25 to 87?years (average age?=?62.6?±?11.4?years) and of the female subjects from 24 to 86?years (average age?=?59.4?±?14.6?years). After incinerating the arteries with nitric acid and perchloric acid, the element content was determined by inductively coupled plasma-atomic emission spectrometry. The Ca and P contents tended to increase in the left coronary arteries of men with age, but the increases were not statistically significant. In the left coronary arteries of women, the Ca and P contents increased significantly and progressively with aging. In addition, the Na content increased significantly in the left coronary arteries of both men and women with aging. The differences in the average contents of Ca and P by age group were observed between the left coronary arteries of men and women. With Student's t test, significant gender differences in the average contents of Ca and P were found in both the 40s and the 70s. The Ca and P contents of the left coronary arteries in the 40s were significantly higher in men than in women. In contrast, the Ca and P contents in the 70s were significantly higher in women than in men. These results indicated that the accumulation of Ca and P in the left coronary arteries of Thais occurred at least 10?years earlier in men than in women, but a higher accumulation of Ca and P in old age occurred in the left coronary arteries of women compared with those of men. The present study revealed that there were significant gender differences in the left coronary arteries with regard to the accumulation of Ca and P with aging. It is reasonable to presume that taking clinical findings into consideration, the gender differences in the left coronary arteries may result from hormonal and/or genetic factors rather than lifestyle factors. 相似文献
9.
Tohno Y Tohno S Laleva L Ongkana N Minami T Satoh H Oishi T Hayashi M Sinthubua A Suwannahoy P Mahakkanukrauh P 《Biological trace element research》2008,125(2):141-153
To elucidate compositional changes of the coronary artery with aging, the authors investigated age-related changes of elements
in the coronary arteries of rhesus and Japanese monkeys by direct chemical analysis in comparison with the coronary arteries
of Japanese and Thai. Used monkeys consisted of 38 rhesus monkeys and 23 Japanese monkeys, ranging in age from newborn to
33 years. After perfusion with a fixative, the hearts were resected from the monkeys, and the anterior interventricular branches
of the left coronary artery and the right coronary arteries were resected from the hearts. After ashing of the arteries, element
contents were determined by inductively coupled plasma-atomic emission spectrometry. It was found that the Ca and P contents
did not increase in both the left and right coronary arteries of rhesus and Japanese monkeys at old age. The average contents
of Ca and P decreased by 13% and 25% in the left coronary arteries more than 20 years of age in comparison with those below
20 years of age, whereas they decreased by 4% and 15% in the right coronary arteries more than 20 years of age in comparison
with those below 20 years of age. This finding indicated that atherosclerosis scarcely occurred in both the left and right
coronary arteries of rhesus and Japanese monkeys at old age. In contrast with monkeys, atherosclerosis occurred frequently
in the coronary arteries of Japanese and Thai at old age. 相似文献
10.
Patipath Suwannahoy Setsuko Tohno Pasuk Mahakkanukrauh Takeshi Minami Yoshiyuki Tohno 《Biological trace element research》2010,135(1-3):56-66
To elucidate compositional changes of the mammillary body with aging, the authors investigated age-related changes of elements, relationships among their elements, and gender differences in the mammillary bodies by direct chemical analysis. After ordinary dissection at Nara Medical University was finished, the mammillary bodies were resected from the cerebra of the subjects. The subjects consisted of 19 men and 25 women, ranging in age from 70 to 101 years (average age?=?83.8?±?7.2 years). After ashing of the mammillary bodies with nitric acid and perchloric acid, element contents were determined by inductively coupled plasma–atomic emission spectrometry. It was found that the Ca content increased slightly and significantly in the mammillary bodies with aging, but the P, S, Mg, Zn, Fe, and Na contents did not change significantly with aging. Regarding the relationships among elements, significant correlations were found among the contents of Ca, P, S, and Mg in the mammillary bodies, with one exception between P and Mg contents. With regard to the seven element contents, no significant gender differences were found in the mammillary bodies. 相似文献