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Hong-Van Tieu Piyarat Suntarattiwong Thanyawee Puthanakit Tawee Chotpitayasunondh Kulkanya Chokephaibulkit Sunee Sirivichayakul Supranee Buranapraditkun Patcharawee Rungrojrat Nitiya Chomchey Simon Tsiouris Scott Hammer Vijay Nandi Jintanat Ananworanich 《PloS one》2014,9(8)
Background
Data on the performance of interferon-gamma release assays (IGRAs), QuantiFERON TB Gold In-tube (QFNGIT) and T-Spot.TB, in diagnosing tuberculosis (TB) are limited in Southeast Asia. This study aims to compare the performances of the two IGRAs and TST in Thai children with recent TB exposure.Methods
This multicenter, prospective study enrolled children with recent exposure to active TB adults. Children were investigated for active TB. TST was performed and blood collected for T-Spot.TB and QFNGIT.Results
158 children were enrolled (87% TB-exposed and 13% active TB, mean age 7.2 years). Only 3 children had HIV infection. 66.7% had TST≥10 mm, while 38.6% had TST≥15 mm. 32.5% had positive QFNGIT; 29.9% had positive T-Spot.TB. QFNGIT and T-Spot.TB positivity was higher among children with active TB compared with TB-exposed children. No indeterminate IGRA results were detected. No statistically significant differences between the performances of the IGRAs and TST at the two cut-offs with increasing TB exposure were detected. Concordance for positive IGRAs and TST ranged from 42–46% for TST≥10 mm and 62–67% for TST≥15 mm. On multivariable analyses, exposure to household primary/secondary caregiver with TB was associated with positive QFNGIT. Higher TB contact score and active TB were associated with positive T-Spot.TB.Conclusions
Both QFNGIT and T-Spot.TB performed well in our Thai pediatric study population. No differences in the performances between tests with increasing TB exposure were found. Due to accessibility and low cost, using TST may more ideal than IGRAs in diagnosing latent and active TB in healthy children in Thailand and other similar settings. 相似文献2.
Jody K. Takemoto Julia Choi Cecilia M. Shikuma Jintanat Ananworanich Kara Bennett Pairoa Praihirunkit Piranun Hongchookiat Pornpen Mathajittiphun Daniel E. LiButti Victor DeGruttola Nittaya Phanuphak Nitiya Chomchey Patcharawee Rungrojrat Nipat Teeratakulpisarn Praphan Phanuphak Tanate Jadwattanakul Mariana Gerschenson 《Mitochondrion》2012,12(5):563
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