Effects of Ethylene Control and Dynamic Controlled Atmosphere Storage on ‘Galaxy’ Apple Quality

Journal of Plant Growth Regulation - This study aimed to evaluate the interaction of ethylene management in the pre- and post-harvest stages using different storage techniques on the...     

Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke

Ischemic stroke is a major cause of morbidity and mortality worldwide and only few affected patients are able to receive treatment, especially in developing countries. Detailed pathophysiology of brain ischemia has been extensively studied in order to discover new treatments with a broad therapeutic window and that are accessible to patients worldwide. The nucleoside guanosine (Guo) has been shown to have neuroprotective effects in animal models of brain diseases, including ischemic stroke. In a rat model of focal permanent ischemia, systemic administration of Guo was effective only when administered immediately after stroke induction. In contrast, intranasal administration of Guo (In-Guo) was effective even when the first administration was 3 h after stroke induction. In order to validate the neuroprotective effect in this larger time window and to investigate In-Guo neuroprotection under global brain dysfunction induced by ischemia, we used the model of thermocoagulation of pial vessels in Wistar rats. In our study, we have found that In-Guo administered 3 h after stroke was capable of preventing ischemia-induced dysfunction, such as bilateral suppression and synchronicity of brain oscillations and ipsilateral cell death signaling, and increased permeability of the blood-brain barrier. In addition, In-Guo had a long-lasting effect on preventing ischemia-induced motor impairment. Our data reinforce In-Guo administration as a potential new treatment for brain ischemia with a more suitable therapeutic window.

     

Entrapped transnationalism: West Bank and Israeli Palestinians between closeness and distance

Studies of transnationalism typically frame it in opposition to the entrapping effects of borders. Yet, for many people, transnationalism is negotiated in contexts marked by forced separation and differential mobility. Drawing on long-term fieldwork among West Bank and Israeli Palestinians, this article explores transnational ties and orientations in relation, not in opposition, to the entrapping effects of borders. Specifically, I examine the two-way traffic in emotions and perceptions that marks family, social and symbolic relationships between West Bank and Israeli Palestinians. I show how entrapping and transnational processes combine to generate a tense interplay between closeness and distance, solidarity and estrangement. The paper calls attention to complex transnational formations among people prone to entrapment such as detained and deported migrants, refugees and minorities divided by rigid borders, and it suggests that a focus on emotions and perceptions is critical if we are to understand such formations.