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Cárdenas-Martínez Karen Johanna Grueso-Mariaca Derly Vargas-Casanova Yerly Bonilla-Velásquez Laura Estupiñán Sandra Mónica Parra-Giraldo Claudia Marcela Leal Aura Lucía Rivera-Monroy Zuly Jenny García-Castañeda Javier Eduardo 《International journal of peptide research and therapeutics》2021,27(3):1751-1762
International Journal of Peptide Research and Therapeutics - Monomeric, dimeric, palindromic, and tetrameric peptides derived from bovine lactoferricin (LfcinB) containing the RRWQWR or the KKWQWK... 相似文献
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Héctor Manuel Pineda-Castañeda Kevin Andrey Huertas-Ortiz Aura Lucía Leal-Castro Yerly Vargas-Casanova Claudia Marcela Parra-Giraldo Javier Eduardo García-Castañeda Zuly Jenny Rivera-Monroy 《化学与生物多样性》2021,18(2):e2000885
Chimeric peptides containing short sequences derived from bovine Lactoferricin (LfcinB) and Buforin II (BFII) were synthetized using solid-phase peptide synthesis (SPPS) and characterized via reversed-phase liquid chromatography and mass spectrometry. The chimeras were obtained with high purity, demonstrating their synthetic viability. The chimeras’ antibacterial activity against Gram-positive and Gram-negative strains was evaluated. Our results showed that all the chimeras exhibited greater antibacterial activity against the evaluated strains than the individual sequences, suggesting that chemical binding of short sequences derived from AMPs significantly increased the antibacterial activity. For each strain, the chimera with the best antibacterial activity exerted a bacteriostatic and/or bactericidal effect, which was dependent on the concentration. It was found that: (i) the antibacterial activity of a chimera is mainly influenced by the linked sequences, the palindromic motif RLLRRLLR being the most relevant one; (ii) the inclusion of a spacer between the short sequences did not significantly affect the chimera's synthesis process; however, it enhanced its antibacterial activity against Gram-negative and Gram-positive strains; on the other hand, (iii) the replacement of Arg with Lys in the LfcinB or BFII sequences improved the chimeras’ synthesis process without significantly affecting their antibacterial activity. These results illustrate the great importance of the synthesis of chimeric peptides for the generation of promising antibacterial peptides. 相似文献
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Soraya Morales-López Andrés Ceballos-Garzón Claudia M. Parra-Giraldo 《Current fungal infection reports》2018,12(4):149-154
Purpose of Review
This review summarizes the reports of Zygomycete fungi infection in Colombia, as well as include the geographical distribution, species identification, and treatment of those clinical cases.Recent Findings
Zygomycosis is not a new disease. However, the use of molecular tools has allowed the identification of some recently described species as their causal agents.Summary
In Colombia, the prevalence of zygomycosis is unclear because reporting is not mandatory and because in many cases the etiological agent was not identified. It is important to establish the mandatory reporting of cases, to know the circulating fungal species, the treatment used, and the outcome of the patients. Regarding the treatment, amphotericin B remains as the best alternative. To our knowledge, this is the first compilation of the published cases of zygomicosis in the country.
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