全文获取类型
收费全文 | 52篇 |
免费 | 4篇 |
出版年
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 3篇 |
2014年 | 3篇 |
2013年 | 1篇 |
2012年 | 1篇 |
2009年 | 1篇 |
2008年 | 2篇 |
2007年 | 3篇 |
2006年 | 5篇 |
2004年 | 2篇 |
2003年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 4篇 |
1997年 | 1篇 |
1994年 | 1篇 |
1993年 | 3篇 |
1990年 | 1篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 4篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1969年 | 1篇 |
排序方式: 共有56条查询结果,搜索用时 484 毫秒
1.
2.
Nielsen J; Peixoto AA; Piccin A; Costa R; Kyriacou CP; Chalmers D 《Molecular biology and evolution》1994,11(6):839-853
The region of the clock gene period (per) that encodes a repetitive tract
of threonine-glycine (Thr-Gly) pairs has been compared between Dipteran
species both within and outside the Drosophilidae. All the non-
Drosophilidae sequences in this region are short and present a remarkably
stable picture compared to the Drosophilidae, in which the region is much
larger and extremely variable, both in size and composition. The
accelerated evolution in the repetitive region of the Drosophilidae appears
to be mainly due to an expansion of two ancestral repeats, one encoding a
Thr-Gly dipeptide and the other a pentapeptide rich in serine, glycine, and
asparagine or threonine. In some drosophilids the expansion involves a
duplication of the pentapeptide sequence, but in Drosophila pseudoobscura
both the dipeptide and the pentapeptide repeats are present in larger
numbers. In the nondrosophilids, however, the pentapeptide sequence is
represented by one copy and the dipeptide by two copies. These observations
fulfill some of the predictions of recent theoretical models that have
simulated the evolution of repetitive sequences.
相似文献
3.
4.
5.
6.
Roepman P de Koning E van Leenen D de Weger RA Kummer JA Slootweg PJ Holstege FC 《Genome biology》2006,7(12):R117-12
Background
Metastasis, the process whereby cancer cells spread, is in part caused by an incompletely understood interplay between cancer cells and the surrounding stroma. Gene expression studies typically analyze samples containing tumor cells and stroma. Samples with less than 50% tumor cells are generally excluded, thereby reducing the number of patients that can benefit from clinically relevant signatures.Results
For a head-neck squamous cell carcinoma (HNSCC) primary tumor expression signature that predicts the presence of lymph node metastasis, we first show that reduced proportions of tumor cells results in decreased predictive accuracy. To determine the influence of stroma on the predictive signature and to investigate the interaction between tumor cells and the surrounding microenvironment, we used laser capture microdissection to divide the metastatic signature into six distinct components based on tumor versus stroma expression and on association with the metastatic phenotype. A strikingly skewed distribution of metastasis associated genes is revealed.Conclusion
Dissection of predictive signatures into different components has implications for design of expression signatures and for our understanding of the metastatic process. Compared to primary tumors that have not formed metastases, primary HNSCC tumors that have metastasized are characterized by predominant down-regulation of tumor cell specific genes and exclusive up-regulation of stromal cell specific genes. The skewed distribution agrees with poor signature performance on samples that contain less than 50% tumor cells. Methods for reducing tumor composition bias that lead to greater predictive accuracy and an increase in the types of samples that can be included are presented. 相似文献7.
N. M. Marples P. W. de Jong M. M. Ottenheim M. D. Verhoog P. M. Brakefield 《Entomologia Experimentalis et Applicata》1993,69(1):69-73
A viable wingless 2spot ladybirdAdalia bipunctata (L.) was found in the wild. Breeding through four generations revealed that the wingless trait was controlled by a recessive
allele which displays variable levels of expression. The wingless ladybird is discussed in relation to its potential as a
biocontrol agent. One ladybird also occurred in this stock which is suggestive of a supergene controlling the colour polymorphism
in this species. 相似文献
8.
9.
10.
Geographic variation in plasticity in Eristalis arbustorum 总被引:2,自引:0,他引:2
Mart M. Ottenheim Anja Henseler Paul M. Brakefield 《Biological journal of the Linnean Society. Linnean Society of London》1998,65(2):215-229
To study the evolution of phenotypic plasticity in the field, six populations of the hoverfly Eristalis arbustorum were sampled along two parallel North-South transects over a maximum daily temperature gradient. Three populations were sampled per transect. Egg batches were collected and the offspring were reared in a split family set up over three different pupal temperature regimes in the laboratory to produce population reaction norms of colour pattern, pupal development time, wing length and thorax length. Wing length and colour pattern were corrected for body size. All four characters showed plasticity in response to rearing temperature and significant differences in height, slope and shape of the reaction norms were found. Only male colour pattern showed variation in reaction norms along the North-South gradient. Most other characters showed variation in reaction norms from West to East. The two populations lying in the middle of the transects were frequendy different from the others. Within the populations, significant genotype-environment interactions were frequently found for wing length and colour pattern, indicating that genetic variation for plasticity was present. The results suggest that the populations may have evolved plastic responses to suit local environmental conditions. 相似文献