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1.
Oswald Hess 《Molecular & general genetics : MGG》1970,107(3):224-242
Summary The phenotype of the variegation position effect white-mottled-2 in Drosophila hydei is modified by supernumerary Y chromosomes and by fractions thereof. Different translocated Y fragments have varying degrees of effectiveness in suppressing the mutant phenotype in the mottled eyes. In fragments derived from similar regions of the Y chromosome the suppressive ability is related to their cytological lengths. In contrast, fragments derived from distinctive regions of the Y chromosome differ markedly in their effectiveness, and these differences are not necessarily correlated with the cytological length. In particular, fragments of the distal region of YL are more effective in enhancing the wild phenotype than are proximal fragments of similar size.The mutation white-mottled-2 is accompanied by a complex rearrangement of the X chromosome. This inhibits crossing over between large regions of the X chromosome in structural heterozygotes; it causes also a delay of development and a considerable reduction of viability in homozygous females and hemizygous males. XO males are inviable. The inviability of these males is partially covered by Y fragments. With respect to viability, the fragments show similar regional differences in effectiveness as in the modification of the mottled phenotype.There is also a parental effect on the modulation of the white-mottled-2 phenotype.There is no correlation between the activity of Y chromosomal factors on spermiogenesis and the activity of Y factors on the modification of the variegation position effect. Suppression of Y chromosomal sites which normally unfold lampbrush loops during the spermatocyte stage and whose activity has previously been shown to be indispensible for normal differentiation of the male germ line cells does not result in any visible alterations of the effectiveness on the mottling. So there is obviously independence between these two different genetic activities of Y chromosomal factors. 相似文献
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The binding of (-)-[3H]nicotine to membrane fragments and a detergent solubilized fraction of goldfish brain was characterized. (-)-[3H]nicotine binding was not displaced by alpha-bungarotoxin, but was displaced by (-)nicotine and carbamoylcholine with Ki of approximately 8.6 and 86 nM, respectively. Preincubation of solubilized membrane extract with alpha-bungarotoxin-coupled Sepharose resulted in the loss of approximately 50% of the (-)-[3H]nicotine binding protein from the eluent and an increase in (-)-[3H]nicotine binding to the gel compared to control, non-alpha-bungarotoxin Sepharose. 125I-alpha-bungarotoxin binding protein in the eluent from the same preincubation experiments was totally removed. In addition, incubation of the solubilized tissue extracts with alpha-bungarotoxin-coupled Sepharose resulted in an increase in the affinity for (-)-[3H]nicotine in the eluent (mean KD = 3.1) compared to control solubilized tissue extracts (KD = 6.4 nM). Specific (-)-[3H]nicotine binding sites could be eluted from the alpha-bungarotoxin-coupled Sepharose with carbamoylcholine and D-tubocurarine. Similar to previously reported 125I-alpha-bungarotoxin binding data, eye removal resulted in an approximately 40% decrease in (-)-[3H]nicotine binding in the contralateral tectum compared to that in the ipsilateral tectum. These data indicate that at least two distinct subtypes of (-)nicotine binding sites may be present in goldfish brain, one which binds alpha-bungarotoxin and (-)nicotine and another which binds only (-)nicotine. 相似文献
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Summary We investigated the effects of thorns and spines on the feeding of 5 herbivore species in arid Australia. The herbivores were the rabbit (Oryctolagus cuniculus), euro kangaroo (Macropus robustus), red kangaroo (Macropus rufus), sheep (Ovis aries), and cattle (Bos taurus). Five woody plants without spines or thorns and 6 woody plants with thorns were included in the study. The spines and thorns were not found to affect the herbivores' rates of feeding (items ingested/min), but they did reduce the herbivores' rates of biomass ingestion (g-dry/item). The reduction in biomass ingested occurred in two ways: at a given diameter, twigs with spines and thorns had less mass than undefended plants, and the herbivores consumed twigs with smaller diameters on plants with spines and thorns. The relative importance of the two ways that twigs with spines and thorns provided less biomass varied with herbivore body mass. Reduced twig mass was more important for small herbivores, while large herbivores selected smaller diameters. The effectiveness of spines and thorns as anti-herbivore defenses did not vary with the evolutionary history of the herbivores (i.e. native vs. introduced). Spines and thorns mainly affected the herbivores' selection of maximum twig sizes (reducing diameter and mass), but the minimum twig sizes selected were also reduced. 相似文献
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Litter size in many mammalian populations varies along a gradient of latitude or altitude. This investigation tested the hypothesis that geographic variation in litter size among populations of the cotton rat is the result of differences in ovulation rate. Oviducts and uteri of virgin and recently mated lab-reared descendants of cotton rats from Kansas (KS), Texas (TX), and Tennessee (TN) were flushed on the day following the last day of estrus. Ovulation rates differ significantly among the three populations for both virgins (mean +/- SEM, KS = 5.3 +/- 0.3, TX = 4.6 +/- 0.5, and TN = 4.0 +/- 0.5) and for females that have recently copulated (KS = 6.5 +/- 0.3, TX = 5.7 +/- 0.7, and TN = 3.7 +/- 0.4; P less than 0.001). These nonvirgin females have significantly higher ovulation rates than virgins for KS and TX (P = 0.01 and 0.05, respectively), but there is no significant effect of copulation on TN. In all populations, ovulation rates of rats that release ova from both ovaries (KS = 6.1 +/- 0.2, TX = 5.9 +/- 0.4, and TN = 5.1 +/- 0.5) are significantly higher than those that use only one ovary (KS = 4.4 +/- 0.4, TX = 3.3 +/- 0.4, and TN = 3.2 +/- 0.3; P less than 0.001). The number of ovaries ovulating differs significantly between populations (P = 0.002). The effect of copulation on the number of ovaries ovulating is marginally significant (P = 0.08).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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V Kyle B Silverman A Silman H King N Oswald B Reiss B Hazleman 《BMJ (Clinical research ed.)》1985,291(6492):385-387
The aim of this study was to establish the incidence and prevalence of polymyalgia rheumatica/giant cell arteritis in general practice. Patients with this disorder, whether previously diagnosed or not, were ascertained by using a questionnaire administered by interview, and all received full clinical and laboratory assessment. A total of 579 patients aged 65 and over was seen, and 19 (33/1000) had been diagnosed or developed symptoms within the previous eight years. Thus the calculated annual incidence in those aged 65 and over was about 4/1000. The figures from this first large scale study of polymyalgia rheumatica/giant cell arteritis in general practice are much higher than those from studies carried out in hospital. The questionnaire was effective in both identifying known cases of polymyalgia rheumatica/giant cell arteritis and detecting new cases. As this is a treatable disorder, it is important that doctors become aware of how common it is in elderly people. 相似文献
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Oswald Kiermayer 《Planta》1971,96(1):74-80
Summary Electronmicroscopic studies of growing and non-growing cells of Micrasterias denticulata Bréb., fixed with glutaraldehyde-OsO4, showed a special kind of cytoplasmic vesicle which has so far not been found in other cells. These particles (1000–1200 Å in diameter) are characterized, by an unusual, multilayered membrane and a rod-like content of high electronoptic density. The vesicles are found to be accumulated in the vicinity of the nucleus and in a positional relationship to the nuclear pores. Although no evidence could be found either for a direct passage of the vesicles through the pores or for a blebbing-process from the nuclear membrane, the rod-containing vesicles could be functional in the process of nuclearcytoplasmic exchange.
Herrn Prof. Dr. H. Drawert zum 60. Geburtstag gewidmet.
Diese Arbeit wurde zum Teil durch ein National Science, Foundation Senior Foreign Scientist Fellowship an Dr. Oswald Kiermayer und durch einen Training Grant 5-T1-GM-707-06 an Dr. Keith R. Porter, Harvard University, unterstützt. 相似文献
Herrn Prof. Dr. H. Drawert zum 60. Geburtstag gewidmet.
Diese Arbeit wurde zum Teil durch ein National Science, Foundation Senior Foreign Scientist Fellowship an Dr. Oswald Kiermayer und durch einen Training Grant 5-T1-GM-707-06 an Dr. Keith R. Porter, Harvard University, unterstützt. 相似文献
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