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Durán-Carabali L. E. Sanches E. F. Odorcyk F. K. Nicola F. Mestriner R. G. Reichert L. Aristimunha D. Pagnussat A. S. Netto C. A. 《Neurochemical research》2019,44(11):2631-2642
Neurochemical Research - Preterm birth and hypoxia–ischemia (HI) are major causes of neonatal death and neurological disabilities in newborns. The widely used preclinical HI model combines... 相似文献
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Luz Elena Durán-Carabali Felipe Kawa Odorcyk Samuel Greggio Gianina Teribele Venturin Eduardo Farias Sanches Guilherme Garcia Schu Andrey Soares Carvalho Thales Avila Pedroso Natividade de Sá Couto-Pereira Jaderson Costa Da Costa Carla Dalmaz Eduardo Rigon Zimmer Carlos Alexandre Netto 《Journal of neurochemistry》2021,157(6):1911-1929
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L. E. Durán-Carabali D. M. Arcego F. K. Odorcyk L. Reichert J. L. Cordeiro E. F. Sanches L. D. Freitas C. Dalmaz A. Pagnussat C. A. Netto 《Molecular neurobiology》2018,55(5):3627-3641
Environmental enrichment (EE) is an experimental strategy to attenuate the negative effects of different neurological conditions including neonatal hypoxia ischemia encephalopathy (HIE). The aim of the present study was to investigate the influence of prenatal and early postnatal EE in animals submitted to neonatal HIE model at postnatal day (PND) 3. Wistar rats were housed in EE or standard conditions (SC) during pregnancy and lactation periods. Pups of both sexes were assigned to one of four experimental groups, considering the early environmental conditions and the injury: SC-Sham, SC-HIE, EE-sham, and EE-HIE. The offspring were euthanized at two different time points: 48 h after HIE for biochemical analyses or at PND 67 for histological analyses. Behavioral tests were performed at PND 7, 14, 21, and 60. Offspring from EE mothers had better performance in neurodevelopmental and spatial memory tests when compared to the SC groups. HIE animals showed a reduction of IGF-1 and VEGF in the parietal cortex, but no differences in BDNF and TrkB levels were found. EE-HIE animals showed reduction in cell death, lower astrocyte reactivity, and an increase in AKTp levels in the hippocampus and parietal cortex. In addition, the EE was also able to prevent the hippocampus tissue loss. Altogether, present findings point to the protective potential of the prenatal and early postnatal EE in attenuating molecular and histological damage, as well as the neurodevelopmental impairments and the cognitive deficit, caused by HIE insult at PND 3. 相似文献
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Eduardo Farias Sanches Lauren Valentim Felipe de Almeida Sassi Lisiane Bernardi Nice Arteni Simone Nardin Weis Felipe Kawa Odorcyk Patricia Pranke Carlos Alexandre Netto 《Neurochemical research》2018,43(12):2268-2276
Neonatal hypoxia-ischemia (HI) is associated to cognitive and motor impairments and until the moment there is no proven treatment. The underlying neuroprotective mechanisms of stem cells are partially understood and include decrease in excitotoxicity, apoptosis and inflammation suppression. This study was conducted in order to test the effects of intracardiac transplantation of human dental pulp stem cells (hDPSCs) for treating HI damage. Seven-day-old Wistar rats were divided into four groups: sham-saline, sham-hDPSCs, HI-saline, and HI-hDPSCs. Motor and cognitive tasks were performed from postnatal day 30. HI-induced cognitive deficits in the novel-object recognition test and in spatial reference memory impairment which were prevented by hDPSCs. No motor impairments were observed in HI animals. Immunofluorescence analysis showed human-positive nuclei in hDPSC-treated animals closely associated with anti-GFAP staining in the lesion scar tissue, suggesting that these cells were able to migrate to the injury site and could be providing support to CNS cells. Our study evidence novel evidence that hDPSC can contribute to the recovery following hypoxia-ischemia and highlight the need of further investigation in order to better understand the exact mechanisms underlying its neuroprotective effects. 相似文献
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