排序方式: 共有4条查询结果,搜索用时 0 毫秒
1
1.
Lebedev L. R. Goncharova E. P. Sizov A. A. Bulychev L. E. Odegov A. M. Ryzhikov A. B. 《Molecular Biology》2003,37(3):464-467
A method was elaborated to construct combined artificial immunogens simulating virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immunogens were constructed and shown to induce biosynthesis of specific antibodies against HIV-1 and the tick-borne encephalitis virus. The level and duration of the humoral and cell responses were assayed. 相似文献
2.
3.
Lebedev LR Sizov AA Karpenko LI Poryvaeva VA Odegov AM 《Molekuliarnaia genetika, mikrobiologiia i virusologiia》2002,(1):17-21
A method for designing molecular constructions of combined artificial immunogens mimicking viral particles is proposed. Using this method, it is possible to expose antigenic determinants of any viral protein on the surface of such particles and to deliver plasmids containing genes encoding the synthesis of protein antigens to target cells. This approach was used to create the constructions of combined artificial immunogens inducing the production of specific antibodies to HIV-1 and to evaluate the extent and duration of B-cellular immune response depending on the way of antigen exposure to immunocompetent cells. 相似文献
4.
Lebedev LR Goncharova EP Sizov AA Bulychev LE Odegov AM Ryzhikov AB 《Molekuliarnaia biologiia》2003,37(3):544-549
A method was elaborated to construct combined artificial immunogens mimicking virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immunogens were constructed and shown to induce biosynthesis of specific antibodies against HIV-1 and the tick-borne encephalitis virus. The level and duration of the humoral and cell responses were assayed. 相似文献
1