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The degree of intergradation between two species of Sulawesi macaques,Macaca tonkeana andM. hecki, was studied by examining the diagnostic external characteristics of more than 100 monkeys kept as pets by natives. Two possible
hybrid monkeys were found and both originated from the borderland between the two species, located in the most proximal region
of the northern peninsula of Sulawesi. The previously postulated wide area of integradation between the two species at the
possible contact zone was, however, not recognized, and typical examples oftonkeana orhecki were found to be present on the two sides of a narrow “hybrid” zone which was defined by direct observations. Furthermore,
despite considerable individual variations, we were able to allocate most monkeys to one or other of the species. Each of
ten external characteristics of the members of both species more or less encompassed the individual variations, but may undergo
changes with the development of the monkeys. The mechanisms of reproduction of hybrid monkeys and the maintenance of differences
between the species are discussed. 相似文献
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Background
Studies on microsporidial infection mostly focus on immunodeficiency or immunosuppressive individuals. Therefore, this cross-sectional study describes the prevalence and risk factors of microsporidiosis among asymptomatic individuals in Malaysia.Methods/Findings
Four hundred and forty seven stool samples were collected and examined for microsporidia after staining with Gram-chromotrope Kinyoun. Demographic, socioeconomic, environmental, and behavioral information were collected by using a pre-tested questionnaire. Overall, 67 (15%) samples were positive for microsporidia. The prevalence of infection was significantly higher among individuals aged more than 15 years compared to those aged <15 years (OR = 1.97, 95% CI = 1.08, 3.62; P = 0.028). Furthermore, logistic regression analysis confirmed that the presence of other family members infected with microsporidia (OR = 8.45; 95% CI = 4.30, 16.62; P<0.001) and being a consumer of raw vegetables (OR = 2.05; 95% CI = 1.15, 3.66; P = 0.016) were the significant risk factors of this infection.Conclusions
These findings clearly show that exposure to microsporidia is common among Aboriginal population. Further studies using molecular approach on microsporidia isolates from asymptomatic individuals is needed to determine species-specific. The risk factors associated with microsporidiosis will help in identifying more clearly the sources of the infection in the environment that pose a risk for transmission so that preventive strategies can be implemented. 相似文献4.
Bousette N Pottinger J Ramli W Ohlstein EH Dhanak D Douglas SA Giaid A 《Peptides》2006,27(11):2919-2926
It is now well established that urotensin-II (UII) levels are increased in several cardiovascular diseases. We previously demonstrated that UII and the UII receptor (UT) protein levels are significantly increased in the hearts of both humans and rats with congestive heart failure (CHF). We have also recently demonstrated that UII blockade, with a selective UII antagonist, improves heart function in a rat model of ischemic CHF. Here, we evaluated the attenuation of cardiac remodeling associated with UII antagonism in the same rat model of ischemic CHF. Animals were administered a specific UT receptor antagonist, SB-611812 (30 mg/kg/day, gavage), or vehicle 30 min prior to coronary artery ligation followed by daily treatment for 8 weeks. Myocardial interstitial fibrosis was analyzed by Masson's trichrome and picrosirius red staining. RT-PCR analysis was utilized for mRNA expression studies. We used Western blotting to assess levels of collagen types I and III. Mitogenic activity of UII on cultured neonatal cardiac fibroblasts was also evaluated. Following coronary ligation, SB-611812 significantly attenuated both myocardial and endocardial interstitial fibrosis, and reduced collagen type I:III ratio (P<0.01). UII induced proliferation of cardiac fibroblasts and this mitogenic effect was significantly inhibited with 1 microM of SB-611218 (P<0.05). We demonstrate here that selective blockade of UT reduces diastolic dysfunction by decreasing myocardial fibrosis post-coronary ligation in vivo, and inhibits UII-mediated fibroblast proliferation in vitro. 相似文献
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Faiqah Ramli Mawardi Rahmani Nur Kartinee Kassim Najihah Mohd Hashim Mohd Aspollah Sukari Abdah Md Akim Rusea Go 《Phytochemistry letters》2013,6(4):582-585
Two new diprenylated dihydrochalcones, elastichalcone A 1 and elastichalcone B 2 and three known compounds were isolated from the leaves of Artocarpus elasticus. Their structures were determined by various spectroscopic techniques (UV, IR, MS, 1D-NMR and 2D-NMR). Elastichalcone B 2 and a known compound exhibited good free radical scavenging activity with IC50 values of 11.30 and 11.89 μg/ml, respectively. 相似文献
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This is the first report of the avian assemblage in the study area of Dutse, Nigeria. In addition to recording bird species, the effects of season, dominant vegetation structure, locality and anthropogenic activities on bird abundance, species richness and diversity were investigated. Using the point transect method, 264 points on 48 km of transect were used to count birds between 06:30 and 11:00 from August 2015 to February 2016. A total of 122 bird species of 41 families were recorded. Highest bird species richness was recorded in Warwade, highest abundance in Model, and highest diversity in Malamawa. The dry season and woodland habitat showed higher bird species richness, abundance and diversity than the wet season and shrubland habitat. Tree density was more important in increasing bird abundance than shrub density. Small-scale anthropogenic activities and habitat modification, such as farming, grazing, wood removal and human interference did not appear to have impacted the birds; however, loss of high tree-density woodland habitats may pose a major threat to the bird community in Dutse. The presence of birds of concern in the area suggests the need for conservation efforts of avifauna and as well as the forested habitats in Dutse. 相似文献
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Kheng-Seang Lim Ai-Huey Tan Chun-Shen Lim Kek-Heng Chua Ping-Chin Lee Norlisah Ramli Giri Shan Rajahram Fatimah Tina Hussin Kum-Thong Wong Meenakshi B. Bhattacharjee Ching-Ching Ng 《PloS one》2015,10(8)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary stroke caused by mutations in NOTCH3 gene. We report the first case of CADASIL in an indigenous Rungus (Kadazan-Dusun) family in Kudat, Sabah, Malaysia confirmed by a R54C (c.160C>T, p.Arg54Cys) mutation in the NOTCH3. This mutation was previously reported in a Caucasian and two Korean cases of CADASIL. We recruited two generations of the affected Rungus family (n = 9) and found a missense mutation (c.160C>T) in exon 2 of NOTCH3 in three siblings. Two of the three siblings had severe white matter abnormalities in their brain MRI (Scheltens score 33 and 50 respectively), one of whom had a young stroke at the age of 38. The remaining sibling, however, did not show any clinical features of CADASIL and had only minimal changes in her brain MRI (Scheltens score 17). This further emphasized the phenotype variability among family members with the same mutation in CADASIL. This is the first reported family with CADASIL in Rungus subtribe of Kadazan-Dusun ethnicity with a known mutation at exon 2 of NOTCH3. The penetrance of this mutation was not complete during the course of this study. 相似文献
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Nicholas J. Berry Oliver L. Phillips Simon L. Lewis Jane K. Hill David P. Edwards Noel B. Tawatao Norhayati Ahmad David Magintan Chey V. Khen M. Maryati Robert C. Ong Keith C. Hamer 《Biodiversity and Conservation》2010,19(4):985-997
The carbon storage and conservation value of old-growth tropical forests is clear, but the value of logged forest is less certain. Here we analyse >100,000 observations of individuals from 11 taxonomic groups and >2,500 species, covering up to 19?years of post-logging regeneration, and quantify the impacts of logging on carbon storage and biodiversity within lowland dipterocarp forests of Sabah, Borneo. We estimate that forests lost ca. 53% of above-ground biomass as a result of logging but despite this high level of degradation, logged forest retained considerable conservation value: floral species richness was higher in logged forest than in primary forest and whilst faunal species richness was typically lower in logged forest, in most cases the difference between habitats was no greater than ca. 10%. Moreover, in most studies >90% of species recorded in primary forest were also present in logged forest, including species of conservation concern. During recovery, logged forest accumulated carbon at five times the rate of natural forest (1.4 and 0.28?Mg?C?ha?1?year?1, respectively). We conclude that allowing the continued regeneration of extensive areas of Borneo??s forest that have already been logged, and are at risk of conversion to other land uses, would provide a significant carbon store that is likely to increase over time. Protecting intact forest is critical for biodiversity conservation and climate change mitigation, but the contribution of logged forest to these twin goals should not be overlooked. 相似文献